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Subcutaneous immunoglobulins in the treatment of chronic immune-mediated neuropathies
This article reviews the current evidence for clinical effectiveness, as well as safety of SCIg for the treatment of immune-mediated neuropathies, and addresses remaining open questions in this context. We conclude that despite the need for controlled long-term studies to demonstrate long-term efficacy of SCIg in immune-mediated neuropathies, SCIg may already represent a potential therapeutic alternative for selected patients. (Source: Therapeutic Advances in Neurological Disorders)
Source: Therapeutic Advances in Neurological Disorders - June 20, 2016 Category: Neurology Authors: Leussink, V. I., Hartung, H.-P., Kieseier, B. C., Stettner, M. Tags: Reviews Source Type: research

Web-based interventions in multiple sclerosis: the potential of tele-rehabilitation
The World Wide Web is increasingly used in therapeutic settings. In this regard, internet-based interventions have proven effective in ameliorating several health behaviors, amongst them physical activity behavior. Internet-delivered interventions have shown positive effects on physical activity and physical function in persons with MS (pwMS). In this review we give an overview on several online exercise programs for pwMS and discuss the advantages and drawbacks of web-based interventions. Although participants of online exercise programs reported a high acceptance and satisfaction with the intervention, decreasing complia...
Source: Therapeutic Advances in Neurological Disorders - June 20, 2016 Category: Neurology Authors: Tallner, A., Pfeifer, K., Mäurer, M. Tags: Reviews Source Type: research

The diagnosis and management of idiopathic intracranial hypertension and the associated headache
Idiopathic intracranial hypertension (IIH) is a challenging disorder with a rapid increasing incidence due to a close relation to obesity. The onset of symptoms is often insidious and patients may see many different specialists before the IIH diagnosis is settled. A summary of diagnosis, symptoms, headache characteristics and course, as well as existing evidence of treatment strategies is presented and strategies for investigations and management are proposed. (Source: Therapeutic Advances in Neurological Disorders)
Source: Therapeutic Advances in Neurological Disorders - June 20, 2016 Category: Neurology Authors: Jensen, R. H., Radojicic, A., Yri, H. Tags: Reviews Source Type: research

Clinical efficacy of combined sodium dimercaptopropanesulfonate and zinc treatment in neurological Wilsons disease with D-penicillamine treatment failure
Conclusions: Our findings indicate that the safety and efficacy of combined treatment of DMPS and zinc is superior to those of zinc monotherapy in patients with neurological WD with a history of DPA treatment failure. (Source: Therapeutic Advances in Neurological Disorders)
Source: Therapeutic Advances in Neurological Disorders - June 20, 2016 Category: Neurology Authors: Chen, D., Zhou, X., Hou, H., Feng, L., Liu, J., Liang, Y., Lin, X., Zhang, J., Wu, C., Liang, X., Pei, Z., Li, X. Tags: Original Research Source Type: research

Direct stroke unit admission of intravenous tissue plasminogen activator: safety, clinical outcome, and hospital cost savings
Conclusions: IV tPA patients may be safely cared for in a SU when nurses undergo extensive education to ensure clinical competence. Use of the ICU solely for monitoring may constitute significant overuse of system resources at an expense that is not associated with additional safety benefit. (Source: Therapeutic Advances in Neurological Disorders)
Source: Therapeutic Advances in Neurological Disorders - June 20, 2016 Category: Neurology Authors: Alexandrov, A. W., Coleman, K. C., Palazzo, P., Shahripour, R. B., Alexandrov, A. V. Tags: Original Research Source Type: research

Immunoadsorption versus plasma exchange versus combination for treatment of myasthenic deterioration
Conclusion: Semiselective IA in combination with PE, and to a lesser extent IA alone, was associated with a shorter hospital stay and more pronounced reduction of the MG score than PE. (Source: Therapeutic Advances in Neurological Disorders)
Source: Therapeutic Advances in Neurological Disorders - June 20, 2016 Category: Neurology Authors: Schneider-Gold, C., Krenzer, M., Klinker, E., Mansouri-Thalegani, B., Müllges, W., Toyka, K. V., Gold, R. Tags: Original Research Source Type: research

Quantitative analysis of multiple sclerosis patients preferences for drug treatment: a best-worst scaling study
Conclusion: This study shows that preferences for drug therapy among patients with MS are different, some of which can be explained by experiences with their disease and treatment. These findings can help to inform the focus of interactions that healthcare practitioners have with patients with MS, as well as further drug development. (Source: Therapeutic Advances in Neurological Disorders)
Source: Therapeutic Advances in Neurological Disorders - June 20, 2016 Category: Neurology Authors: Lynd, L. D., Traboulsee, A., Marra, C. A., Mittmann, N., Evans, C., Li, K. H., Carter, M., Hategekimana, C. Tags: Original Research Source Type: research

Immunoadsorption in patients with neuromyelitis optica spectrum disorder
Discussion: In this small cohort, IA constitutes a valid therapeutic option for patients with NMOSD as an equivalent to PLEX. Analysis in larger cohorts is warranted. (Source: Therapeutic Advances in Neurological Disorders)
Source: Therapeutic Advances in Neurological Disorders - June 20, 2016 Category: Neurology Authors: Faissner, S., Nikolayczik, J., Chan, A., Gold, R., Yoon, M.-S., Haghikia, A. Tags: Original Research Source Type: research

Cognitive functions over the course of 1 year in multiple sclerosis patients treated with disease modifying therapies
Conclusions: Cognitive functions remain relatively stable under DMT treatment over 1 year, irrespective of the type of medication. Furthermore, the tests PASAT and SPART should be interpreted cautiously in studies examining performance changes over time. The provided RCI norms may help clinicians to determine whether a difference in two measurements observed in a RRMS patient is reliable. (Source: Therapeutic Advances in Neurological Disorders)
Source: Therapeutic Advances in Neurological Disorders - June 20, 2016 Category: Neurology Authors: Utz, K. S., Lee, D.-H., Lämmer, A., Waschbisch, A., Linker, R. A., Schenk, T. Tags: Original Research Source Type: research

One-time intrathecal triamcinolone acetonide application alters the redox potential in cerebrospinal fluid of progressive multiple sclerosis patients: a pilot study
Conclusion: Intrathecal steroid application alters the redox potential in cerebrospinal fluid. Our findings support the beneficial role of steroids on oxidative stress generally demonstrated by ascorbyl radical appearance. Reactive oxygen species decline is necessary for an upregulated production of reduced proteins. (Source: Therapeutic Advances in Neurological Disorders)
Source: Therapeutic Advances in Neurological Disorders - June 20, 2016 Category: Neurology Authors: Müller, T., Herrling, T., Lütge, S., Lohse, L., Öhm, G., Jung, K. Tags: Original Research Source Type: research

Therapy satisfaction and adherence in patients with relapsing-remitting multiple sclerosis: the THEPA-MS survey
Conclusion: In a connected model of patient satisfaction, effectiveness, side effects, convenience and adherence, patients’ individual needs and concerns have to be addressed. Most differences were found with respect to side effects and convenience of treatment. Therefore, an improvement in these two domains seems to be the most promising proximate approach to elevate adherence levels. (Source: Therapeutic Advances in Neurological Disorders)
Source: Therapeutic Advances in Neurological Disorders - June 20, 2016 Category: Neurology Authors: Haase, R., Kullmann, J. S., Ziemssen, T. Tags: Original Research Source Type: research

Incidence, characterization, and clinical impact analysis of peginterferon beta1a immunogenicity in patients with multiple sclerosis in the ADVANCE trial
Conclusion: The treatment effect of peginterferon beta1a in patients with relapsing–remitting MS is not expected to be attenuated by immunogenicity. (Source: Therapeutic Advances in Neurological Disorders)
Source: Therapeutic Advances in Neurological Disorders - June 20, 2016 Category: Neurology Authors: White, J. T., Newsome, S. D., Kieseier, B. C., Bermel, R. A., Cui, Y., Seddighzadeh, A., Hung, S., Crossman, M., Subramanyam, M. Tags: Original Research Source Type: research

Noninvasive vagus nerve stimulation in the management of cluster headache: clinical evidence and practical experience
The efficacy of invasive vagal nerve stimulation as well as other invasive neuromodulatory approaches such as deep brain stimulation, occipital nerve stimulation, and ganglion sphenopalatine stimulation has been shown in the treatment of headache disorders in several studies in the past. However, these invasive treatment options were quite costly and often associated with perioperative and postoperative side effects, some severe. As such, they were predominantly restricted to chronic and therapy refractory patients. Transcutaneous vagal nerve stimulation now offers a new, noninvasive neuromodulatory treatment approach. Rec...
Source: Therapeutic Advances in Neurological Disorders - March 22, 2016 Category: Neurology Authors: Holle-Lee, D., Gaul, C. Tags: Reviews Source Type: research

Diagnostic workup and management of patients with suspected Niemann-Pick type C disease
Niemann-Pick type C (NP-C) disease is a neurovisceral disorder caused by mutations in the NPC1 and NPC2 genes. It is characterized by lysosomal storage of a broad range of lipids as a result of abnormal intracellular lipid trafficking. Typically patients develop neurodegeneration; however, the speed of disease progression is variable. The exact functions of NPC1 and NPC2 proteins have not been determined and therefore the molecular pathophysiology of NP-C is still not clearly understood. Due to the disease’s rarity and clinical heterogeneity, delays from symptom onset to diagnosis and treatment initiation are common....
Source: Therapeutic Advances in Neurological Disorders - March 22, 2016 Category: Neurology Authors: Papandreou, A., Gissen, P. Tags: Reviews Source Type: research

Use of interleukin-2 for management of natalizumab-associated progressive multifocal leukoencephalopathy: case report and review of literature
A 51-year-old woman with relapsing–remitting multiple sclerosis (RRMS) and 3-year history of natalizumab use developed expressive aphasia. A brain magnetic resonance image (MRI) showed left frontotemporal and right parietal lesion with mild contrast enhancement and cerebrospinal fluid (CSF) was positive for John Cunningham virus (JCV) by polymerase chain reaction (PCR). The patient received five cycles of plasmapheresis followed by intravenous immunoglobulin. Despite this intervention, her speech deteriorated and she developed right hemiparesis. Upon referral to our institution, CSF quantitative JCV PCR was notable f...
Source: Therapeutic Advances in Neurological Disorders - March 22, 2016 Category: Neurology Authors: Dubey, D., Zhang, Y., Graves, D., DeSena, A. D., Frohman, E., Greenberg, B. Tags: Reviews Source Type: research