Therapeutic Advances in Musculoskeletal Disease This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Trigger finger: ultrasound-guided injection with an in-plane approach under the A1 pulley
(Source: Therapeutic Advances in Musculoskeletal Disease)
Source: Therapeutic Advances in Musculoskeletal Disease - March 15, 2016 Category: Orthopaedics Authors: Yildizgören, M. T., Velioglu, O., Guler, H. Tags: Letters to the Editor Source Type: research

A case of missed ocular torticollis
(Source: Therapeutic Advances in Musculoskeletal Disease)
Source: Therapeutic Advances in Musculoskeletal Disease - March 15, 2016 Category: Orthopaedics Authors: Toopchizadeh, V., Zolghadr, M., Nabie, R. Tags: Letters to the Editor Source Type: research

Disease-modifying antirheumatic drugs improve cardiovascular autonomic neuropathy in psoriatic arthritis
Conclusion: These study results suggests parasympathetic autonomic dysfunction is more prominent than sympathetic dysfunction in PsA. Synthetic DMARDs improved parasympathetic dysfunction in PsA. (Source: Therapeutic Advances in Musculoskeletal Disease)
Source: Therapeutic Advances in Musculoskeletal Disease - March 15, 2016 Category: Orthopaedics Authors: Syngle, A., Verma, I., Krishan, P., Syngle, V. Tags: Original Research Source Type: research

Homologous platelet-rich plasma for the treatment of knee osteoarthritis in selected elderly patients: an open-label, uncontrolled, pilot study
Conclusions: Homologous PRP has an excellent safety profile but offers only a short-term clinical improvement in selected elderly patients with knee OA who are not candidates for autologous PRP treatment. Increasing age and developing degeneration result in a decreased potential for homologous PRP injection therapy. Further studies are needed to confirm these findings. (Source: Therapeutic Advances in Musculoskeletal Disease)
Source: Therapeutic Advances in Musculoskeletal Disease - March 15, 2016 Category: Orthopaedics Authors: Bottegoni, C., Dei Giudici, L., Salvemini, S., Chiurazzi, E., Bencivenga, R., Gigante, A. Tags: Original Research Source Type: research

Fibrin glue for olecranon bursitis: a case report
(Source: Therapeutic Advances in Musculoskeletal Disease)
Source: Therapeutic Advances in Musculoskeletal Disease - January 7, 2016 Category: Orthopaedics Authors: Berkoff, D. J., Sandbulte, Z. W., Stafford, H. C., Berkowitz, J. N. Tags: Letter to the Editor Source Type: research

Osteoporosis in men: findings from the Osteoporotic Fractures in Men Study (MrOS)
The lifespan of men is increasing and this is associated with an increased prevalence of osteoporosis in men. Osteoporosis increases the risk of bone fracture. Fractures are associated with increased disability and mortality, and public health problems. We review here the study of osteoporosis in men as obtained from a longitudinal cohort of community-based older men, the Osteoporotic Fractures in Men Study (MrOS). (Source: Therapeutic Advances in Musculoskeletal Disease)
Source: Therapeutic Advances in Musculoskeletal Disease - January 7, 2016 Category: Orthopaedics Authors: Cawthon, P. M., Shahnazari, M., Orwoll, E. S., Lane, N. E. Tags: Review Source Type: research

Latest therapeutic advances in musculoskeletal disease from the ACR 2015 annual conference
(Source: Therapeutic Advances in Musculoskeletal Disease)
Source: Therapeutic Advances in Musculoskeletal Disease - January 7, 2016 Category: Orthopaedics Authors: Reid, D. M., Mallarkey, G. Tags: Editorials Source Type: research

Osteoporosis therapeutics: recent developments at ASBMR
(Source: Therapeutic Advances in Musculoskeletal Disease)
Source: Therapeutic Advances in Musculoskeletal Disease - January 7, 2016 Category: Orthopaedics Authors: Mallarkey, G., Reid, D. M. Tags: Editorials Source Type: research

Treatment of rheumatoid arthritis-associated interstitial lung disease: a perspective review
Rheumatoid arthritis (RA) is a systemic autoimmune disease affecting 0.5–1% of the worldwide population. Whilst predominantly causing chronic pain and inflammation in synovial joints, it is also associated with significant extra-articular manifestations in a large proportion of patients. Among the various pulmonary manifestations, interstitial lung disease (ILD), a progressive fibrotic disease of the lung parenchyma, is the commonest and most important, contributing significantly to increased morbidity and mortality. The most frequent patterns of RA-associated ILD (RA-ILD) are usual interstitial pneumonia and nonspec...
Source: Therapeutic Advances in Musculoskeletal Disease - November 3, 2015 Category: Orthopaedics Authors: Iqbal, K., Kelly, C. Tags: Reviews Source Type: research

Key issues in the management of patients with systemic lupus erythematosus: latest developments and clinical implications
This article reviews these key issues in SLE management, outlining recent developments and clinical implications for patients. (Source: Therapeutic Advances in Musculoskeletal Disease)
Source: Therapeutic Advances in Musculoskeletal Disease - November 3, 2015 Category: Orthopaedics Authors: Jordan, N., D'Cruz, D. Tags: Reviews Source Type: research

Hyperuricaemia with deposition: latest evidence and therapeutic approach
In conclusion, a worldwide definition of gout is still lacking, stages from hyperuricaemia to clinical gout not being definitively defined. Although there is increasing interest on the impact of early deposits on joint damage and cardiovascular outcomes, robust evidence is still lacking to fully support interventions. (Source: Therapeutic Advances in Musculoskeletal Disease)
Source: Therapeutic Advances in Musculoskeletal Disease - November 3, 2015 Category: Orthopaedics Authors: Perez-Ruiz, F., Marimon, E., Chinchilla, S. P. Tags: Reviews Source Type: research

Towards an understanding of the role of DNA methylation in rheumatoid arthritis: therapeutic and diagnostic implications
The term ‘epigenetics’ loosely describes DNA-templated processes leading to heritable changes in gene activity and expression, which are independent of the underlying DNA sequence. Epigenetic mechanisms comprise of post-translational modifications of chromatin, methylation of DNA, nucleosome positioning as well as expression of noncoding RNAs. Major advances in understanding the role of DNA methylation in regulating chromatin functions have been made over the past decade, and point to a role of this epigenetic mechanism in human disease. Rheumatoid arthritis (RA) is an autoimmune disorder where altered DNA meth...
Source: Therapeutic Advances in Musculoskeletal Disease - September 15, 2015 Category: Orthopaedics Authors: Cribbs, A., Feldmann, M., Oppermann, U. Tags: Reviews Source Type: research

Sarcoidosis: a rheumatologist's perspective
Sarcoidosis is a systemic disorder of unknown etiology, which may involve various tissues and organs and is characterized by a noncaseating granuloma reaction. While pathogenesis is not yet clear, cellular immune system activation and nonspecific inflammatory response occur secondarily to several genetic and environmental factors. T helper 1-cells and macrophage-derived pro-inflammatory cytokines stimulate the inflammatory cascade and formation of granuloma occurs as a result of tissue permeability, cell influx, and local cell proliferation. The different prevalence, clinical results, and disease course observed in differe...
Source: Therapeutic Advances in Musculoskeletal Disease - September 15, 2015 Category: Orthopaedics Authors: Kobak, S. Tags: Reviews Source Type: research

Atherosclerosis in psoriatic disease: latest evidence and clinical implications
It is widely accepted that atherosclerosis is caused by chronic low-grade inflammation that results from an interaction between immune mechanisms and metabolic abnormalities within the vessel wall. Population-based studies have found an increased cardiovascular risk in patients with psoriasis and psoriatic arthritis (PsA). This risk is higher in patients with severe disease phenotypes, such as those with severe psoriasis and with musculoskeletal inflammation. Higher levels of inflammatory biomarkers also predict the development of clinical cardiovascular events in these patients. The effect of medications used for PsA on c...
Source: Therapeutic Advances in Musculoskeletal Disease - September 15, 2015 Category: Orthopaedics Authors: Eder, L., Gladman, D. D. Tags: Reviews Source Type: research

Making the next steps in psoriatic arthritis management: current status and future directions
Psoriatic arthritis (PsA) is a chronic inflammatory condition with articular and extra-articular manifestations: peripheral arthritis, axial disease, enthesitis, dactylitis, and skin and nail disease. It is associated with cardiovascular comorbidities. It is now recognized as a new entity, different from rheumatoid arthritis and other spondyloarthritis in terms of clinical manifestations, pathogenesis, and response to therapies. Anti-tumor necrosis factors (anti-TNFs) have demonstrated clinical efficacies exceeding that of conventional disease modifying antirheumatic drugs (DMARDs). The current treatment paradigms recommen...
Source: Therapeutic Advances in Musculoskeletal Disease - September 15, 2015 Category: Orthopaedics Authors: Sritheran, D., Leung, Y. Y. Tags: Reviews Source Type: research