Approvals
(Source: The Brown University Psychopharmacology Update)
Source: The Brown University Psychopharmacology Update - August 13, 2015 Category: Psychiatry Tags: From the FDA Source Type: research

Research Roundup
Maintenance naltrexone reduces reinforcing effects of marijuana SSRIs improve women's response in postnatal depression Aripiprazole augmentation outpaces switching in treatment‐resistant depression Antipsychotic use in pregnancy may not increase medical risks Once‐daily dasotraline shows promise in treating adult ADHD Swedish study questions concerns over adverse events from varenicline (Source: The Brown University Psychopharmacology Update)
Source: The Brown University Psychopharmacology Update - August 13, 2015 Category: Psychiatry Tags: Research Roundup Source Type: research

Mortality study indicates importance of persisting with lithium treatment regimen
A nationwide cohort study of Veterans Health Administration (VHA) records has found significantly reduced nonsuicide mortality over the first 90 days of lithium treatment compared with valproate treatment, but increased mortality over 180 days relative to valproate in individuals discontinuing lithium treatment. Study authors stated that their findings point to the importance of emphasizing persistence with lithium treatment and engaging in close monitoring of patients who stop treatment. (Source: The Brown University Psychopharmacology Update)
Source: The Brown University Psychopharmacology Update - August 13, 2015 Category: Psychiatry Tags: What's New in Research Source Type: research

Citicoline has early effect on cocaine use in bipolar disorder patients
The endogenous nucleotide citicoline was effective in reducing cocaine use in a group of outpatients with cocaine dependence and bipolar I disorder, but the effects of the treatment diminished somewhat over time, a new study has found. Citicoline did not result in significant differences from placebo in manic or depressive symptoms, the researchers found. (Source: The Brown University Psychopharmacology Update)
Source: The Brown University Psychopharmacology Update - August 13, 2015 Category: Psychiatry Tags: What's New in Research Source Type: research

Risk of atrial fibrillation in antidepressant users
Atrial fibrillation is the most common type of arrhythmia in elderly patients, and it is not uncommon for patients with recurrent atrial fibrillation to exhibit depressive symptoms and be treated with antidepressants. Research data suggest a potential role of 5‐HT4 receptors in atrial arrhythmias, including chronic atrial fibrillation.1,2 Antidepressant use has been associated with adverse cardiac risk (including ischemic stroke, the most common cardiovascular complication of atrial fibrillation), as well as conduction abnormalities and sudden death.3,4 A recent study examined whether there is an increased risk of chroni...
Source: The Brown University Psychopharmacology Update - August 13, 2015 Category: Psychiatry Authors: Y. W. Francis Lam Tags: Drug‐Drug Interactions Source Type: research