Measuring adherence to antipsychotic medications for schizophrenia: Concordance and validity among a community sample in rural China
Despite the abundance of measures to assess medication adherence by persons suffering schizophrenia, few studies have evaluated their concordance and validity against a reference standard in resource-poor community settings. We explored the concordance and validity of several measures to assess antipsychotic medication adherence in a resource-poor community. (Source: Schizophrenia Research)
Source: Schizophrenia Research - May 25, 2018 Category: Psychiatry Authors: Dong (Roman) Xu, Wenjie Gong, Steve Gloyd, Eric D. Caine, Jane Simoni, James P. Hughes, Shuiyuan Xiao, Wenjun He, Bofeng Dai, Meijuan Lin, Juan Nie, Hua He Source Type: research
Low-pleasure beliefs in patients with schizophrenia and individuals with social anhedonia
Anhedonia in schizophrenia has been suggested to comprise a set of low-pleasure beliefs, defined as beliefs that certain things/activities were not pleasurable or that one does not feel pleasant generally. However, no instrument has been intentionally developed to specifically measure low-pleasure beliefs, and there is a paucity of empirical evidence for low-pleasure beliefs and their relationship with anhedonia in both patients with schizophrenia and individuals with high social anhedonia. We developed and validated the Beliefs About Pleasure Scale (BAPS) using non-clinical (Studies 1, 2& 3), chronic schizophrenia (Study ...
Source: Schizophrenia Research - May 25, 2018 Category: Psychiatry Authors: Yin Yang, Zhuo-ya Yang, Ying-min Zou, Hai-song Shi, Yi Wang, Dong-jie Xie, Rui-ting Zhang, Simon S.Y. Lui, Alex C. Cohen, Gregory P. Strauss, Eric F.C. Cheung, Raymond C.K. Chan Source Type: research
60 years of placebo-controlled antipsychotic drug trials in acute schizophrenia: Meta-regression of predictors of placebo response
A recent meta-regression had shown that the degree of placebo response, which has increased over the decades, is the major predictor of drug-placebo differences in antipsychotic drug trials in acutely ill patients with schizophrenia. Drug response, however, had remained stable. In the current meta-regression we explored the factors that are associated with placebo-response. (Source: Schizophrenia Research)
Source: Schizophrenia Research - May 24, 2018 Category: Psychiatry Authors: Stefan Leucht, Anna Chaimani, Claudia Leucht, Maximilian Huhn, Dimitris Mavridis, Bartosz Helfer, Myrto Samara, Andrea Cipriani, John R. Geddes, Georgia Salanti, John M. Davis Source Type: research
Examining relationships between psychotic experiences and suicidal ideation in adolescents using a network approach
Suicide is one of the leading causes of death in young individuals. Timely and adequate identification of individuals with suicidal ideation could prevent from suicidal behavior. Psychotic experiences (PE) have been shown to increase levels of suicidal ideation (SI) in the general population. Therefore, detailed investigation of the relationship of PE and SI is relevant. However, the exact nature of the relationship between these two phenomena remains unclear. Understanding psychopathology as a complex network of interacting symptoms could be helpful to elucidate specific associations existing between PE and SI. (Source: S...
Source: Schizophrenia Research - May 24, 2018 Category: Psychiatry Authors: D. N úñez, A. Fresno, C.D. van Borkulo, P. Courtet, V. Arias, V. Garrido, J.T.W. Wigman Source Type: research
Effect of emotional cues on prospective memory performance in patients with schizophrenia and major depressive disorder
This study examined the influence of emotional cues on PM performance in patients with schizophrenia and major depressive disorder. All participants were required to respond to emotional or neutral PM cues while completing a working memory task. Healthy participants showed improved PM performance with positive and negative cues. (Source: Schizophrenia Research)
Source: Schizophrenia Research - May 24, 2018 Category: Psychiatry Authors: Tian-xiao Yang, Xi-long Cui, Ya Wang, Jing Huang, Simon S.Y. Lui, Rui-ting Zhang, Eric F.C. Cheung, Raymond C.K. Chan Source Type: research
Factor structure of the positive and negative syndrome scale (PANSS) in people at ultra high risk (UHR) for psychosis
The Positive and Negative Syndrome Scale (PANSS), a comprehensive psychopathology assessment scale used in the evaluation of psychopathology in schizophrenia, is also often used in the Ultra-High-Risk (UHR) population. This paper examined the dimensional structure of the PANSS in a UHR sample. (Source: Schizophrenia Research)
Source: Schizophrenia Research - May 24, 2018 Category: Psychiatry Authors: Zixu Yang, Keane Lim, Max Lam, Richard Keefe, Jimmy Lee Source Type: research
The association between problem gambling and psychotic experiences: Findings from the Adult Psychiatric Morbidity Survey 2007
Studies on the association between psychotic experiences (PEs) and problem gambling are lacking. Thus, we examined the association between PEs and problem gambling in the general UK population. (Source: Schizophrenia Research)
Source: Schizophrenia Research - May 24, 2018 Category: Psychiatry Authors: Louis Jacob, Josep Maria Haro, Ai Koyanagi Source Type: research
Relationship between antipsychotic blood levels and treatment failure during the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) study
Antipsychotic blood levels (ABLs) may help identify patients at risk for treatment failure. Reference ranges (RR) for plasma concentrations of ABLs that account for between-patient variability were developed for risperidone and olanzapine based on population pharmacokinetic models. The Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) collected clinical outcomes and ABLs, allowing testing of the relationship of ABLs with outcomes. (Source: Schizophrenia Research)
Source: Schizophrenia Research - May 24, 2018 Category: Psychiatry Authors: Rama Melkote, Arun Singh, An Vermeulen, Bart Remmerie, Adam Savitz Source Type: research
Increased plasticity of bodily self-experience in individuals who may carry latent liability for schizophrenia
Self-disturbances such as altered perception of one's own body boundary are central to the lived-in experience of schizophrenia. Bodily self-disturbances are also prevalent in healthy individuals who may carry latent liability for schizophrenia. Much of the research on self-disturbances rely on clinical interviews but these experiences are often difficult to verbalize, conceptualize and quantify. Furthermore, experimental evidence for plasticity of bodily self-experience in the schizophrenia-spectrum is scarce. (Source: Schizophrenia Research)
Source: Schizophrenia Research - May 21, 2018 Category: Psychiatry Authors: Taylor L. Benson, Sohee Park Source Type: research
Predictors of falls and fractures leading to hospitalization in people with schizophrenia spectrum disorder: A large representative cohort study
To investigate predictors of falls/fractures leading to hospitalisation in people with schizophrenia-spectrum disorders. (Source: Schizophrenia Research)
Source: Schizophrenia Research - May 21, 2018 Category: Psychiatry Authors: Brendon Stubbs, Christoph Mueller, Fiona Gaughran, John Lally, Davy Vancampfort, Sarah E. Lamb, Ai Koyanagi, Shalini Sharma, Robert Stewart, Gayan Perera Source Type: research
Evidence that the association of childhood trauma with psychosis and related psychopathology is not explained by gene-environment correlation: A monozygotic twin differences approach
Converging evidence supports childhood trauma as possible causal risk for psychosis and related psychopathology. However, studies have shown that baseline psychotic symptoms may actually increase risk for subsequent victimization, suggesting that exposure to CT is not random but may result from pre-existing vulnerability. Therefore, studies testing whether the association between CT and psychopathology persists when accounting for gene-environment correlation are much needed. (Source: Schizophrenia Research)
Source: Schizophrenia Research - May 21, 2018 Category: Psychiatry Authors: Aleksandra Lecei, Jeroen Decoster, Marc De Hert, Catherine Derom, Nele Jacobs, Claudia Menne-Lothmann, Jim van Os, Evert Thiery, Bart P.F. Rutten, Marieke Wichers, Ruud van Winkel Source Type: research
Systems-level analysis of risk genes reveals the modular nature of schizophrenia
Schizophrenia (SCZ) is a complex mental disorder with high heritability. Genetic studies (especially recent genome-wide association studies) have identified many risk genes for schizophrenia. However, the physical interactions among the proteins encoded by schizophrenia risk genes remain elusive and it is not known whether the identified risk genes converge on common molecular networks or pathways. Here we systematically investigated the network characteristics of schizophrenia risk genes using the high-confidence protein-protein interactions (PPI) from the human interactome. (Source: Schizophrenia Research)
Source: Schizophrenia Research - May 19, 2018 Category: Psychiatry Authors: Jiewei Liu, Ming Li, Xiong-Jian Luo, Bing Su Source Type: research
Childhood trauma and clinical high risk for psychosis
In this study, we examined the relationship of trauma history to symptoms and functioning in individuals diagnosed with the CHR syndrome on the Structured Interview for Psychosis-Risk Syndromes (N = 103). (Source: Schizophrenia Research)
Source: Schizophrenia Research - May 18, 2018 Category: Psychiatry Authors: Rachel L. Loewy, Sarah Corey, Felix Amirfathi, Sawsan Dabit, Daniel Fulford, Rahel Pearson, Jessica P.Y. Hua, Danielle Schlosser, Barbara K. Stuart, Daniel H. Mathalon, Sophia Vinogradov Source Type: research
Cortical thickness correlates of minor neurological signs in patients with first episode psychosis
Neurological soft signs (NSS) are subtle abnormalities of motor and sensory function that are present in the absence of localized brain pathological lesions. In psychoses they have been consistently associated with a distinct pattern of cortical and subcortical brain structural alterations at the level of the heteromodal cortex and basal ganglia. However, a more specific and accurate evaluation of the cytoarchitecture of the cortical mantle could further advance our understanding of the neurobiological substrate of psychosis. (Source: Schizophrenia Research)
Source: Schizophrenia Research - May 18, 2018 Category: Psychiatry Authors: Simone Ciufolini, Maria Francesca Ponteduro, Tiago Reis-Marques, Heather Taylor, Valeria Mondelli, Carmine M. Pariante, Stefania Bonaccorso, Raymond Chan, Andy Simmons, Anthony David, Marta Di Forti, Robin M. Murray, Paola Dazzan Source Type: research
Of minds and men: Suits, spirits, and psychosis
Steve wore a professorial beard and lush sideburns. He spoke clearly, uncharacteristic of the diagnosis he carried of schizophrenia. He asked us as soon as my classmates and I introduced ourselves and shook his hand: “so when are you letting me out of here?” (Source: Schizophrenia Research)
Source: Schizophrenia Research - May 17, 2018 Category: Psychiatry Authors: Edward Christopher Dee Tags: Letter to the Editor Source Type: research
