Assessment of Sensitivity and Specificity of Ultrasound and Magnetic Resonance Imaging in the Diagnosis of Placenta Accreta
Conclusion The ultras ound and the magnetic resonance imaging showed similar sensitivity and specificity for the diagnosis of placenta accreta.Resumo Objetivo Avaliar e comparar a sensibilidade e especificidade da ultrassonografia e da resson ância magnética no diagnóstico do acretismo placentário em pacientes com placenta prévia. Métodos Estudo de coorte retrospectivo com 37 mulheres, sendo 16 com acretismo placentário, realizado de janeiro de 2013 a outubro de 2015. Considerou-se padrãoouro para o diagnóstico de acretismo pl acentário o exame anatomopatológico, sendo que, na sua ausência, a descrição d...
Source: Revista Brasileira de Ginecologia e Obstetricia - April 15, 2019 Category: OBGYN Source Type: research

Accuracy of Prenatal Diagnosis of Congenital Cardiac Malformations
Conclusion There is a high proportion of congenital heart disease in pregnancies with no risk factors for this outcome. Faced with the disappointing results of obstetric ultrasound for the detection of congenital heart diseases and the current unfeasibility of universal screening of congenital heart diseases through fetal echocardiography, the importance of the fetal morphological ultrasound and its performance by qualified professionals is reinforced for a more appropriate management of these pregnancies.Resumo Objetivo Avaliar a acur ácia do diagnóstico de cardiopatias congênitas obtidos por meio das ecografias rea...
Source: Revista Brasileira de Ginecologia e Obstetricia - April 15, 2019 Category: OBGYN Source Type: research

Association between Dietary Glycemic Index and Excess Weight in Pregnant Women in the First Trimester of Pregnancy
Conclusion A high dietary GI was associated with excess weight in women in the first trimester of pregnancy.Resumo Objetivo Avaliar a associa ção entre índice glicêmico (IG) dietético e presença de excesso de peso em gestantes no primeiro trimestre de gestação. Métodos Estudo transversal realizado com 217 gestantes atendidas no Ambulatório de Medicina Materno-Fetal do Hospital Geral de Fortaleza, Fortaleza, CE, para realizaçã o de exames ultrassonográficos de rotina no período entre 11 e 13 semanas e 6 dias de gestação. Peso e altura foram obtidos para o cálculo do índice de massa corporal (IMC) gest...
Source: Revista Brasileira de Ginecologia e Obstetricia - April 15, 2019 Category: OBGYN Source Type: research

The Need for a Competence Matrix in Delivery Rooms for the Proper Work of Multiprofessional Teams
(Source: Revista Brasileira de Ginecologia e Obstetricia)
Source: Revista Brasileira de Ginecologia e Obstetricia - April 15, 2019 Category: OBGYN Source Type: research

Refractory Severe Thrombocytopenia during Pregnancy: How to Manage
We present the case of a 23-year-old pregnant woman with a history of Langerhans cell histiocytosis of the mandible submitted to surgery and chemotherapy when she was 10 years old, with diagnosis of ITP since then. At 28 weeks of gestation, she presented with petechiae, epistaxis, and gingival bleeding, with a platelet count of 3 x 109/L and positive IgG antiplatelet antibodies test. At a multidisciplinary discussion, it was decided to delay a cesarean section, due to the absence of fetal distress and to the high risk of morbidity for the patient. Many therapies were attempted without success. The IgG produced a slight and...
Source: Revista Brasileira de Ginecologia e Obstetricia - January 21, 2019 Category: OBGYN Source Type: research

Radiation-Induced Uterine Carcinosarcoma after Concurrent Chemoradiotherapy for Cervical Squamous Cell Carcinoma
Conclusion The present case highlights one of the less common but more serious consequences of radiotherapy for cervical cancer, which has an increasing incidence in younger women, raising concerns about the long-termconsequences of its management. (Source: Revista Brasileira de Ginecologia e Obstetricia)
Source: Revista Brasileira de Ginecologia e Obstetricia - January 21, 2019 Category: OBGYN Source Type: research

Impacts of Cytochrome P450 2D6 (CYP2D6) Genetic Polymorphism in Tamoxifen Therapy for Breast Cancer Impactos do polimorfismo genético do citocromo P450 2D6 (CYP2D6) na terapia com tamoxifeno para câncer de mama
Abstract Tamoxifen (TMX) is the main drug used both in pre and postmenopausal women as adjuvant treatment for hormone receptor-positive breast cancer. An important barrier to the use of TMXis the development ofdrug resistance causedby molecular processes related to genetic and epigenetic mechanisms, such as the actions of cytochrome P450 2D6 (CYP2D6) polymorphisms and of its metabolites. The present study aimed to review recent findings related to the impact of CYP2D6 polymorphisms and how they can affect the results of TMX in breast cancer treatment. The keywords CYP2D6, tamoxifen, and breast cancer were searched in the P...
Source: Revista Brasileira de Ginecologia e Obstetricia - January 21, 2019 Category: OBGYN Source Type: research

Female Genito-Pelvic Pain/Penetration Disorder: Review of the Related Factors and Overall Approach
Abstract Genito-pelvic pain/penetration disorder (GPPPD) can be an extremely bothersome condition for patients, and a tough challenge for professionals regarding its assessment and treatment. The goal of the present paper is to review the etiology, assessment, and treatment of GPPPD, especially focusing on the cognitive aspects of the disease and cognitive-behavioral treatment options, through a non-systematic review of articles indexed to the Medline, Scopus and Web of Science databases, using the following MeSH queries: pelvic pain; dyspareunia; vaginismus; vulvodynia; and cognitive therapy. Altogether, 36 articles discu...
Source: Revista Brasileira de Ginecologia e Obstetricia - January 21, 2019 Category: OBGYN Source Type: research

Identification of a Subtype of Poorly Differentiated Invasive Ductal Carcinoma of the Breast Based on Vimentin and E-cadherin Expression
Conclusion Our findings suggest that the expression of VIM and CDH1 can identify a subset of IDCs of the breast with a mesenchymal phenotype associated with poor prognosis, high-grade lesion, and high mitotic index.Resumo Objetivo O uso de marcadores moleculares pode identificar subtipos tumorais com diferentes taxas de recidiva. O objetivo do presente estudo é caracterizar a expressão imunohistoquímica da vimentina (VIM), da E-caderina (CDH1) e de CK5 em pacientes com carcinoma ductal invasivo (CDI) da mama. Métodos Utilizamos uma matriz de amostras teciduais (TMA, na sigla em inglês) de 87 pacientes com CDI da ...
Source: Revista Brasileira de Ginecologia e Obstetricia - January 21, 2019 Category: OBGYN Source Type: research

Sexual Function of Women with Infertility
Conclusion Infertilewomenhadno increased riskof sexual dysfunction relativetocontrols. Anxiety and depression increased the risk of sexual dysfunction in the studied population.Resumo Objetivo Avaliar a fun ção sexual, ansiedade e depressão de mulheres inférteis em relação a um grupo controle. Métodos Mulheres inférteis (grupo infértil, GI) em idade reprodutiva foram convidadas a participar deste estudo. Um grupo controle (GC) de mulheres foi recrutado da população geral da mesma cidade. A função sexual foi avaliada pelo Índice de Função Sexual Feminina (FSFI, na sigla eminglês), e ansiedade e depres...
Source: Revista Brasileira de Ginecologia e Obstetricia - January 21, 2019 Category: OBGYN Source Type: research

Electrophysiological Responses to Different Follicle- Stimulating Hormone Isoforms on Human Cumulus Oophorus Cells: Preliminary Results
Conclusion Both FSH isoforms induced similar depolarization patterns, but β -follitropin presented a faster response. A better understanding of the differences of the effects of FSH isoforms on cell membrane potential shall contribute to improve the use of gonadotrophins in fertility treatments.Resumo Objetivo O objetivo do presente estudo foi fornecer uma melhor compreens ão da ação específica de duas isoformas de hormônio folículo estimulante (FSH, sigla em inglês) ( β -folitropina e FSH ovino) no potencial de membrana de c élulas do cumulus oophorus humanas. Métodos Dados eletrofisiológicos foram associ...
Source: Revista Brasileira de Ginecologia e Obstetricia - January 21, 2019 Category: OBGYN Source Type: research

Circulating Tissue Inhibitor of Metalloproteinase-4 levels are not a Predictor of Preeclampsia in the period between 20 and 25 Weeks of Gestation
Conclusion Plasma TIMP-4 levels were not altered at 20 to 25 weeks of gestation, before the manifestation of clinical symptoms; therefore, they are not good predictors of the development of preeclampsia.Resumo Objetivo Avaliar se o n ível de inibidor tecidual de metaloproteinases tipo-4 (TIMP-4, na sigla em inglês) circulante no período entre 20 e 25 semanas de gestação é um preditor de preeclâmpsia. Métodos Foi realizado um estudo caso-controle aninhado em uma coorte de estudo prospectivo em Ribeirão Preto, São Paul o, Brasil. De 1.400 mulheres grávidas avaliadas entre 20 e 25 semanas de gestação, 460 ti...
Source: Revista Brasileira de Ginecologia e Obstetricia - January 21, 2019 Category: OBGYN Source Type: research

Association between Caffeine Consumption in Pregnancy and Low Birth Weight and Preterm Birth in the birth Cohort of Ribeirão Preto
Conclusion In this cohort, high caffeine intake was lower than in other studies and no association with LBW or preterm birth was found.Resumo Objetivo Descrever a associa ção entre consumo de cafeína durante a gestação com baixo peso ao nascer (BPN) e nascimento pré-termo (PT) na coorte de Ribeirão Preto, estado de São Paulo, Brasil, em 2010. Métodos Estudo de coorte, com abordagem descritiva e analítica. Foram incluídas 7.607 mulheres e seus recém-nasc idos em Ribeirão Preto, São Paulo, Brasil. As mulheres responderam a questionários padronizados sobre saúde reprodutiva, cuidados pré-natais, hábitos...
Source: Revista Brasileira de Ginecologia e Obstetricia - January 21, 2019 Category: OBGYN Source Type: research

Umbilical Cord Blood Gas Analysis, Obstetric Performance and Perinatal Outcome
Conclusion The pHua and the BDua are predictors of adverse neonatal outcome, and UCBGA is a useful tool for screening newborns at risk. Universal UCBGA should be considered for all deliveries, as it is an accurate screening test for neonatal hypoxia.Resumo Objetivo Avaliar se o pH da art éria umbilical (pHua) ≤ 7,00 e o d éficit de bases da artéria umbilical (BDua) ≥ 12,00 mmol/L s ão preditores de desfechos neonatais adversos. Métodos Estudo observacional, longitudinal e retrospectivo, realizado no Serviço de Ginecolocgia e Obstetrícia do Centro Hospitalar Tondela Viseu durante o período de setembro de 20...
Source: Revista Brasileira de Ginecologia e Obstetricia - January 21, 2019 Category: OBGYN Source Type: research

The Role of Caspase-3, Apoptosis-Inducing Factor, and B-cell Lymphoma-2 Expressions in Term Premature Rupture of Membrane
Conclusion High caspase-3 and AIF expressions and low Bcl-2 expression were risk factors for term PROM. Caspase-dependent and independent pathways of apoptosis were involved in the mechanism of PROM in term pregnancy. (Source: Revista Brasileira de Ginecologia e Obstetricia)
Source: Revista Brasileira de Ginecologia e Obstetricia - January 21, 2019 Category: OBGYN Source Type: research