Tidal breathing flow profiles during sleep in wheezing children measured by impedance pneumography
Publication date: Available online 1 October 2019Source: Respiratory Physiology & NeurobiologyAuthor(s): Javier Gracia-Tabuenca, Ville-Pekka Seppä, Milla Jauhiainen, Marita Paassilta, Jari Viik, Jussi KarjalainenAbstractFor the first time, impedance pneumography (IP) enables a continuous analysis of the tidal breathing flow volume (TBFV), overnight. We studied how corticosteroid inhalation treatments, sleep stage, and time from sleep onset modify the nocturnal TBFV profiles of children. Seventy children, 1―5 years old and with recurrent wheezing, underwent three, full-night TBFVs recordings at home, using IP. The first ...
Source: Respiratory Physiology and Neurobiology - October 1, 2019 Category: Respiratory Medicine Source Type: research

Relaxin-3 receptor (RXFP3) activation in the nucleus of the solitary tract modulates respiratory rate and the arterial chemoreceptor reflex in rat
Publication date: Available online 27 September 2019Source: Respiratory Physiology & NeurobiologyAuthor(s): Werner I. Furuya, Rishi R. Dhingra, Andrew L. Gundlach, Mohammad Akhter Hossain, Mathias DutschmannAbstractThe neuropeptide relaxin-3 is expressed by the pontine nucleus incertus. Relaxin-3 and synthetic agonist peptides modulate arousal and cognitive processes via activation of the relaxin-family peptide 3 receptor (RXFP3). Despite the presence of RXFP3 in the nucleus of the solitary tract (NTS), the ability of RXFP3 to modulate NTS-mediated cardiorespiratory functions has not been explored. Therefore, we examined t...
Source: Respiratory Physiology and Neurobiology - September 28, 2019 Category: Respiratory Medicine Source Type: research

Determining the fluid ordered and disordered phases in a pulmonary surfactant by electron spin resonance technique
Publication date: Available online 24 September 2019Source: Respiratory Physiology & NeurobiologyAuthor(s): Alejandra Cimato, Graciela Facorro, Margarita Martínez SarrasagueAbstractPulmonary surfactant main function is to reduce surface tension at alveolar interface. Two lipids phases coexist in surfactant membranes: a liquid-ordered (Lo) and a liquid-disordered (Ld) phases. This coexistence of phases would be crucial for the surfactant activity. Until now, the proportion of phases was determined qualitatively. We design an electronic spin resonance technique to quantify the lipid fraction in Ld phase.An exogenous pulmona...
Source: Respiratory Physiology and Neurobiology - September 25, 2019 Category: Respiratory Medicine Source Type: research

Cough, sniff and maximal static pressure patterns in spinal muscular atrophy
Publication date: Available online 24 September 2019Source: Respiratory Physiology & NeurobiologyAuthor(s): Sonia Khirani, Alessandro Amaddeo, Brigitte FaurouxAbstractIn spinal muscular atrophy (SMA), respiratory muscles are heterogeneously involved with a weakness of the intercostal muscles, possibly of the abdominal wall muscles, and a relatively spared diaphragm, resulting in cough impairment. An abnormal inspiratory cough phase pattern has been reported in SMA II and III. This short communication analyzed the esogastric pressures during voluntary cough in 49 SMA II and III patients. Four different patterns of coughing,...
Source: Respiratory Physiology and Neurobiology - September 25, 2019 Category: Respiratory Medicine Source Type: research

Reduced Cerebrovascular and Cardioventilatory Responses to Intermittent Hypoxia in Elderly
ConclusionsThe elderly adults safely tolerated cyclic, moderate hypoxemia which lowered SaO2 by 2025%, despite dampening of cerebrovascular and cardiac responses to hypoxemia. (Source: Respiratory Physiology and Neurobiology)
Source: Respiratory Physiology and Neurobiology - September 24, 2019 Category: Respiratory Medicine Source Type: research