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Cutaneous larva migrans.
CONCLUSION: The pruritic serpiginous track is pathognomonic. Oral ivermectin is the treatment of choice. PMID: 28078983 [PubMed - as supplied by publisher] (Source: Recent Patents on Inflammation and Allergy Drug Discovery)
Source: Recent Patents on Inflammation and Allergy Drug Discovery - January 14, 2017 Category: Allergy & Immunology Tags: Recent Pat Inflamm Allergy Drug Discov Source Type: research

Rifaximin - Chitosan Nanoparticles for Inflammatory Bowel Disease ( IBD).
CONCLUSION: Nanoparticles with small particle size found to have high encapsulation efficiency and relatively high loading capacity and predetermined in vitro release profile. PMID: 28034350 [PubMed - as supplied by publisher] (Source: Recent Patents on Inflammation and Allergy Drug Discovery)
Source: Recent Patents on Inflammation and Allergy Drug Discovery - January 1, 2017 Category: Allergy & Immunology Tags: Recent Pat Inflamm Allergy Drug Discov Source Type: research

Probiotics in Curing Allergic and Inflammatory Conditions - Research Progress and Futuristic Vision.
CONCLUSION: Present review gives an insight towards potent utility of this branch of beneficial microbial therapy in allergy and inflammations, which is still in the emerging phase and more scientific evidences need to be explored regarding exploration of the mechanisms of action, further experimental trials and validation of controlled clinical studies in humans along with designing novel strategies for monitoring the possible microbial changes in their composition and metabolism associated with their interaction upon host immune system. PMID: 28029082 [PubMed - as supplied by publisher] (Source: Recent Patents on...
Source: Recent Patents on Inflammation and Allergy Drug Discovery - December 29, 2016 Category: Allergy & Immunology Tags: Recent Pat Inflamm Allergy Drug Discov Source Type: research

Heat Shock Proteins: Therapeutic perspectives in inflammatory disorders.
Authors: Khandia R, Munjal AK, Iqbal HM, Dhama K Abstract Heat shock proteins (HSPs) are the highly conserved proteins present in all kingdoms of organisms. These are expressed under stress conditions in order to protect the cells from injuries. The stress induced protein denaturation is rectified by refolding and remodelling. These are intracellular proteins but can be present in extracellular fluid like serum of the patients suffering from trauma, autoimmune diseases and inflammatory disorders. Virtually in all the inflammatory diseases, immune response towards HSPs is developed. HSPs modulate the proces...
Source: Recent Patents on Inflammation and Allergy Drug Discovery - December 18, 2016 Category: Allergy & Immunology Tags: Recent Pat Inflamm Allergy Drug Discov Source Type: research

Recent trends in nanotechnology-based drugs and formulations for targeted therapeutic delivery.
Authors: Iqbal HM, Villalba A, Khandia R, Munjal A, Dhama K Abstract In the recent past, a wider spectrum of nanotechnology-based drugs or drug-loaded devices/systems has been engineered and investigated though using different methodological approaches including in-vitro, in-vivo, and ex-vivo techniques. Among them, nanoparticles-based therapeutic agents have been exploited for an enhanced and efficient delivery in the current biomedical sector of the modern world. However, the development of new types of novel, efficient and highly reliable therapeutic drug delivery system (DDS) for multipurpose applicati...
Source: Recent Patents on Inflammation and Allergy Drug Discovery - December 18, 2016 Category: Allergy & Immunology Tags: Recent Pat Inflamm Allergy Drug Discov Source Type: research

Cytotoxicity and Anti-inflammatory Activity of Flavonoid Derivatives Targeting NF-kappaB.
CONCLUSION: The compound (10b) was found to be most potent as both anti-inflammatory and cytotoxic agents. In silico approach was in good tune with the wet lab experiments. The promising compounds have shown to induce cell cycle arrest at G2/M Phase. PMID: 27842477 [PubMed - as supplied by publisher] (Source: Recent Patents on Inflammation and Allergy Drug Discovery)
Source: Recent Patents on Inflammation and Allergy Drug Discovery - November 16, 2016 Category: Allergy & Immunology Tags: Recent Pat Inflamm Allergy Drug Discov Source Type: research

A Magnetic Resonance Spectroscopy study of lovastatin for treating Bipolar Mood disorder, A-4 week Randomized Double Blind, Placebo- Controlled Clinical Trial.
CONCLUSION: Using MRS after treating with Lovastatin showed lovastatin increases NAA in cingulate gyrus, indicating the possible effect of NAA for increasing the reduced viable neuron. Moreover, the increment of Cr by lovastatin in the left basal ganglia suggests the role of lovastatin for maintaining energy homeostasis, anti-apoptotic activity and ATP production in bipolar disorder.Some patents on the use of lovastatin as an adjuant therapy for treating bipolar patients and depression in MDD patients are also outlined. This trial was registered in the Iranian Clinical Trials Registry (http://www.irct.ir/)(IRCT201302203930...
Source: Recent Patents on Inflammation and Allergy Drug Discovery - November 4, 2016 Category: Allergy & Immunology Tags: Recent Pat Inflamm Allergy Drug Discov Source Type: research

Synthetic and natural nutritional supplements: health "allies" or risk to public health?
CONCLUSION: From the safety/ quality point of view NS lack harmonisation and sovereign laws/ institutional controls on the market, while due to their wide commercialization may possibly lead to risks to public health. PMID: 27670346 [PubMed - as supplied by publisher] (Source: Recent Patents on Inflammation and Allergy Drug Discovery)
Source: Recent Patents on Inflammation and Allergy Drug Discovery - September 29, 2016 Category: Allergy & Immunology Tags: Recent Pat Inflamm Allergy Drug Discov Source Type: research

Ursolic Acid and Oleanolic Acid: Pentacyclic Terpenoids with Promising Anti-Inflammatory Activities.
Authors: Kashyap D, Sharma A, Tuli HS, Punia S, Sharma AK Abstract BACKGROUND: Plant derived products are not only served as dietary components but also used to treat and prevent the inflammatory associated diseases like cancer. Among the natural products pentacyclic terpenoids including ursolic acid and oleanolic acid are considered as the promising anti-inflammatory therapeutic agents. OBJECTIVES: The current review extensively discusses the anti-inflammatory therapeutic potential of these pentacyclic moieties along with their proposed mechanisms of action. Furthermore, the relevant patents have ...
Source: Recent Patents on Inflammation and Allergy Drug Discovery - August 19, 2016 Category: Allergy & Immunology Tags: Recent Pat Inflamm Allergy Drug Discov Source Type: research

Determinants of Grip Strength in Tunisian nurses: a bicentric study.
CONCLUSION: Grip Strength Test is a useful tool to assess physical performance and functional capacity at work in healthcare workers .Further longitudinal studies are required to confirm this hypothesis. PMID: 27280724 [PubMed - as supplied by publisher] (Source: Recent Patents on Inflammation and Allergy Drug Discovery)
Source: Recent Patents on Inflammation and Allergy Drug Discovery - June 11, 2016 Category: Allergy & Immunology Tags: Recent Pat Inflamm Allergy Drug Discov Source Type: research

Recent patents for the treatment of asthma.
CONCLUSION: Pharmacogenomic point of view is now being considered by most major pharmaceutical companies as line of investigation without end in the nearest horizon. Pharmacogenomics has the potential to notably improve the safety and effectiveness of medications. PMID: 27262358 [PubMed - as supplied by publisher] (Source: Recent Patents on Inflammation and Allergy Drug Discovery)
Source: Recent Patents on Inflammation and Allergy Drug Discovery - June 7, 2016 Category: Allergy & Immunology Tags: Recent Pat Inflamm Allergy Drug Discov Source Type: research

Actinic keratosis pathogenesis update and new patents.
Conclusion Although several efforts have been done in the field of actinic keratosis, new upgrades in diagnosis and therapy are needed to detect superficial actinic keratosis earlier, to improve the disease free survival of patient and to threat better the field cancerization. PMID: 27142784 [PubMed - as supplied by publisher] (Source: Recent Patents on Inflammation and Allergy Drug Discovery)
Source: Recent Patents on Inflammation and Allergy Drug Discovery - May 6, 2016 Category: Allergy & Immunology Tags: Recent Pat Inflamm Allergy Drug Discov Source Type: research

Role of Galectins in Allergic Disorders.
CONCLUSION: Taken all together, better learning of galectin biology together with detailed revealing of galectin-immune system interactions have great potential for immune interventions targeting allergy-related disorders. PMID: 27112441 [PubMed - as supplied by publisher] (Source: Recent Patents on Inflammation and Allergy Drug Discovery)
Source: Recent Patents on Inflammation and Allergy Drug Discovery - April 27, 2016 Category: Allergy & Immunology Tags: Recent Pat Inflamm Allergy Drug Discov Source Type: research

Fixed Drug Eruption Due to Selective Hypersensitivity to Naproxen with Tolerance to other Propionic Acid NSAIDs.
CONCLUSION: In our patient PT confirmed the diagnosis and allowed us to study the cross-reactivity between NSAIDs of the same group, and confirmed by SBOCT. Cross-reactivity between propionic acid derivatives was studied. This is a case of hypersensitivity to naproxen with good tolerance to other propionic acids NSAIDs (ibuprofen and ketoprofen) and nabumetone, confirmed by PT and SBOCT. Some relavent patents for fixed drug eruption are discussed. PMID: 27041368 [PubMed - as supplied by publisher] (Source: Recent Patents on Inflammation and Allergy Drug Discovery)
Source: Recent Patents on Inflammation and Allergy Drug Discovery - April 6, 2016 Category: Allergy & Immunology Tags: Recent Pat Inflamm Allergy Drug Discov Source Type: research

Spontaneous (Autoimmune?) Chronic Urticaria in children: current evidences, diagnostic pitfalls and therapeutical management.
CONCLUSION: Most pediatric studies relied on autologous serum skin test only, in order to evidence autoimmune urticaria, which make such a diagnosis be incomplete. A complete diagnostic assessment of pediatric autoimmune chronic urticaria, demonstrating an antibody-mediated mechanism, could ameliorate the therapeutical management, supporting the use of omalizumab rather than other immuno-suppressive therapy in cases resistant to the first-line treatments. PMID: 26899967 [PubMed - as supplied by publisher] (Source: Recent Patents on Inflammation and Allergy Drug Discovery)
Source: Recent Patents on Inflammation and Allergy Drug Discovery - February 25, 2016 Category: Allergy & Immunology Tags: Recent Pat Inflamm Allergy Drug Discov Source Type: research