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The impact of permissive and restrictive pharmaceutical policies on quetiapine dispensing: Evaluating a policy pendulum using interrupted time series analysis
ConclusionMore nuanced policies are needed to ensure the appropriate access to 25‐mg quetiapine for dose escalation while discouraging use for indications where the evidence of risk and benefit is unclear. (Source: Pharmacoepidemiology and Drug Safety)
Source: Pharmacoepidemiology and Drug Safety - February 1, 2018 Category: Drugs & Pharmacology Authors: Jonathan Brett, Andrea Schaffer, Timothy Dobbins, Nicholas A. Buckley, Sallie ‐Anne Pearson Tags: ORIGINAL REPORT Source Type: research

Impact of Florida's prescription drug monitoring program and pill mill law on high ‐risk patients: A comparative interrupted time series analysis
ConclusionsCompared with Georgia, Florida's prescription drug monitoring program and pill mill law were associated with large relative reductions in prescription opioid utilization among high‐risk patients. (Source: Pharmacoepidemiology and Drug Safety)
Source: Pharmacoepidemiology and Drug Safety - February 1, 2018 Category: Drugs & Pharmacology Authors: Hsien ‐Yen Chang, Irene Murimi, Mark Faul, Lainie Rutkow, G. Caleb Alexander Tags: ORIGINAL REPORT Source Type: research

Primary non ‐adherence and the new‐user design
(Source: Pharmacoepidemiology and Drug Safety)
Source: Pharmacoepidemiology and Drug Safety - February 1, 2018 Category: Drugs & Pharmacology Authors: Xiaojuan Li, Stephen R. Cole, Daniel Westreich, M. Alan Brookhart Tags: COMMENTARY Source Type: research

Severe intestinal malabsorption associated with ACE inhibitor or angiotensin receptor blocker treatment. An observational cohort study in Germany and Italy
ConclusionsWe could not confirm previous findings of a higher risk of malabsorption in olmesartan‐only patients, and drug‐induced enteropathy should be considered the result of exposure to the class of ARBs rather than a specific drug‐related effect. (Source: Pharmacoepidemiology and Drug Safety)
Source: Pharmacoepidemiology and Drug Safety - February 1, 2018 Category: Drugs & Pharmacology Authors: Peter Malfertheiner, Claudio Ripellino, Nazarena Cataldo Tags: ORIGINAL REPORT Source Type: research

Meningococcal conjugate vaccine safety surveillance in the Vaccine Safety Datalink using a tree ‐temporal scan data mining method
ConclusionsAs a pilot study, we demonstrated that the tree‐temporal scan statistic data mining method can be successfully applied to screen broadly for a wide range of vaccine‐AE associations within a large health care data network. (Source: Pharmacoepidemiology and Drug Safety)
Source: Pharmacoepidemiology and Drug Safety - February 1, 2018 Category: Drugs & Pharmacology Authors: Rongxia Li, Eric Weintraub, Michael M. McNeil, Martin Kulldorff, Edwin M. Lewis, Jennifer Nelson, Stanley Xu, Lei Qian, Nicola P. Klein, Frank Destefano Tags: ORIGINAL REPORT Source Type: research

Methods for addressing “innocent bystanders” when evaluating safety of concomitant vaccines
ConclusionWe have shown that when using a self‐controlled design to investigate safety of concomitant vaccination, it can be critically important to adjust for time‐invariant effect modifying risk factors, such as age at time of vaccination, which are structurally related to vaccination patterns due to recommended immunization schedules. (Source: Pharmacoepidemiology and Drug Safety)
Source: Pharmacoepidemiology and Drug Safety - February 1, 2018 Category: Drugs & Pharmacology Authors: Shirley V. Wang, Abdurrahman Abdurrob, Julia Spoendlin, Edwin Lewis, Sophia R. Newcomer, Bruce Fireman, Matthew F. Daley, Jason M. Glanz, Jonathan Duffy, Eric S. Weintraub, Martin Kulldorff Tags: ORIGINAL REPORT Source Type: research

Importance of the lipid ‐related pathways in the association between statins, mortality, and cardiovascular disease risk: The Multi‐Ethnic Study of Atherosclerosis
ConclusionsThe estimated effect of statins on mortality, CVD, and CHD appeared to be independent of their estimated effect on HDL and triglycerides. Our study provides evidence that the preventive effect of statins on CHD could be attributed in large part to their effect on LDL. Our g‐formula estimator is a promising approach to elucidate pathways, even if it is hard to make firm conclusions for the LDL pathway on mortality and CVD. (Source: Pharmacoepidemiology and Drug Safety)
Source: Pharmacoepidemiology and Drug Safety - February 1, 2018 Category: Drugs & Pharmacology Authors: Denis Talbot, Joseph A. (Chris) Delaney, Veit Sandfort, David M. Herrington, Robyn L. McClelland Tags: ORIGINAL REPORT Source Type: research

Addressing unmeasured confounding in comparative observational research
Pharmacoepidemiology and Drug Safety, EarlyView. (Source: Pharmacoepidemiology and Drug Safety)
Source: Pharmacoepidemiology and Drug Safety - January 30, 2018 Category: Drugs & Pharmacology Source Type: research

Generalized boosted modeling to identify subgroups where effect of dabigatran versus warfarin may differ: An observational cohort study of patients with atrial fibrillation
Pharmacoepidemiology and Drug Safety, EarlyView. (Source: Pharmacoepidemiology and Drug Safety)
Source: Pharmacoepidemiology and Drug Safety - January 30, 2018 Category: Drugs & Pharmacology Source Type: research

New statin use and left ventricular structure: Estimating long ‐term associations in the Multi‐Ethnic Study of Atherosclerosis (MESA)
Pharmacoepidemiology and Drug Safety, EarlyView. (Source: Pharmacoepidemiology and Drug Safety)
Source: Pharmacoepidemiology and Drug Safety - January 30, 2018 Category: Drugs & Pharmacology Source Type: research

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Pharmacoepidemiology and Drug Safety, Ahead of Print. (Source: Pharmacoepidemiology and Drug Safety)
Source: Pharmacoepidemiology and Drug Safety - January 30, 2018 Category: Drugs & Pharmacology Source Type: research

Generalized boosted modeling to identify subgroups where effect of dabigatran versus warfarin may differ: An observational cohort study of patients with atrial fibrillation
ConclusionsWe explored use of GBM to identify potential subgroups with different treatment effect. Dabigatran's superiority to warfarin at prevention of thromboembolism may be greater in secondary than primary prevention. In practice, secondary prevention patients are more often treated with warfarin. (Source: Pharmacoepidemiology and Drug Safety)
Source: Pharmacoepidemiology and Drug Safety - January 30, 2018 Category: Drugs & Pharmacology Authors: Shirley V. Wang, Krista F. Huybrechts, Michael A. Fischer, Jessica M. Franklin, Robert J. Glynn, Sebastian Schneeweiss, Joshua J. Gagne Tags: ORIGINAL REPORT Source Type: research

Exceeding the daily dosing limit of nonsteroidal anti ‐inflammatory drugs among ibuprofen users
Pharmacoepidemiology and Drug Safety,Volume 27, Issue 3, Page 322-331, March 2018. (Source: Pharmacoepidemiology and Drug Safety)
Source: Pharmacoepidemiology and Drug Safety - January 26, 2018 Category: Drugs & Pharmacology Source Type: research