The Mammoth Professor
(Source: Oral Diseases)
Source: Oral Diseases - February 26, 2018 Category: ENT & OMF Authors: JH Meurman Tags: PROF SCULLY MEMORIAL ISSUE Source Type: research
The importance of studying oral and craniofacial manifestations of Mendelian phenotypes
(Source: Oral Diseases)
Source: Oral Diseases - February 26, 2018 Category: ENT & OMF Authors: JC Atkinson Tags: PROF SCULLY MEMORIAL ISSUE Source Type: research
Learning from clinical phenotypes: Low ‐dose biophotonics therapies in oral diseases
This narrative review on the use of biophotonics therapies for management of oral diseases is written as a tribute to Prof. Crispian Scully. His seminal contributions to the field are highlighted by the detailed, comprehensive description of clinical presentations of oral diseases. This has enabled a more thorough, fundamental understanding of many of these pathologies by research from his group as well as inspired mechanistic investigations in many groups globally. In the same vein, a major emphasis of this narrative review is to focus on the evidence from human case reports rather than in vitro or in vivo animal studies ...
Source: Oral Diseases - February 26, 2018 Category: ENT & OMF Authors: SU Rahman, RC Mosca, S Govindool Reddy, SC Nunez, S Andreana, TS Mang, PR Arany Tags: PROF SCULLY MEMORIAL ISSUE Source Type: research
The medically compromised patient: Are dental implants a feasible option?
In healthy subjects, dental implants have evolved to be a common therapy to solve problems related to stability and retention of dentures as well as to replace failing teeth. Although dental implants are applied in medically compromised patients, it is often not well known whether this therapy is also feasible in these patients, whether the risk of implant failure and developing peri‐implantitis is increased, and what specific preventive measures, if any, have to be taken when applying dental implants in these patients. Generally speaking, as was the conclusion by the leading review of Diz, Scully, and Sanz on placement ...
Source: Oral Diseases - February 26, 2018 Category: ENT & OMF Authors: A Vissink, FKL Spijkervet, GM Raghoebar Tags: PROF SCULLY MEMORIAL ISSUE Source Type: research
Ellagic acid inhibits HIV ‐1 infection in vitro: Potential role as a novel microbicide
ConclusionWe conclude that ellagic acid can inhibit HIV‐1 infection without cytotoxicity. Thus, it may be a new effective agent that has potential to be developed as a novel microbicide against HIV‐1. (Source: Oral Diseases)
Source: Oral Diseases - February 26, 2018 Category: ENT & OMF Authors: A Promsong, T Chuenchitra, K Saipin, S Tewtrakul, P Panichayupakaranant, S Satthakarn, W Nittayananta Tags: PROF SCULLY MEMORIAL ISSUE Source Type: research
Direct oral anticoagulants: A retrospective study of bleeding, behavior, and documentation
ConclusionsBleeding was not observed with direct oral anticoagulation use in this oral surgery cohort. Drug discontinuation/continuation was not a factor in bleeding outcomes, and direct oral anticoagulation interruption was variable and poorly documented. (Source: Oral Diseases)
Source: Oral Diseases - February 26, 2018 Category: ENT & OMF Authors: SG Miller, CS Miller Tags: PROF SCULLY MEMORIAL ISSUE Source Type: research
Medication ‐related osteonecrosis of the jaw: Surgical or non‐surgical treatment?
Medication‐related osteonecrosis of the jaw (MRONJ) is a severe side effect of antiresorptive (bisphosphonates and denosumab) and anti‐angiogenic therapy used in the management of oncologic and, less frequently, osteoporotic patients. While there is good international agreement on the diagnostic and staging criteria of MRONJ and the cessation of antiresorptive/anti‐angiogenic treatments, the gold standard of treatment is still controversial, in particular between non‐surgical and surgical approaches. The former usually includes antiseptic mouth rinse, cyclic antibiotic therapy, low‐level laser therapy and periodi...
Source: Oral Diseases - February 26, 2018 Category: ENT & OMF Authors: G Favia, A Tempesta, L Limongelli, V Crincoli, E Maiorano Tags: PROF SCULLY MEMORIAL ISSUE Source Type: research
Chikungunya fever: General and oral healthcare implications
Chikungunya virus (CHIKV) was first isolated in humans in 1952, following an epidemic in Tanzania. The origin of the name means “to bend forward or become contorted,” in reference to the posture adopted by patients due to the joint pain that occurs during the infection. Epidemiology data suggest that by the end of 2015, about 1.6 million people had been infected with CHIKV. The acute period of the disease is characterized by high fever, myalgia, joint pain, and severe and disabling polyarthritis, sometimes accompanied by headache, backache, and maculopapular rash, predominantly on the thorax. Around half of the patient...
Source: Oral Diseases - February 26, 2018 Category: ENT & OMF Authors: JC Leao, CDL Marques, ALBP Duarte, OP Almeida, S Porter, LA Gueiros Tags: PROF SCULLY MEMORIAL ISSUE Source Type: research
Management of dental patients taking direct oral anticoagulants: Dabigatran
Direct oral anticoagulants (DOACs) are increasingly used as alternatives to warfarin because of the superior pharmacokinetic properties. Clinical guidelines on the influences of DOACs for dental procedures have emerged, but all of necessity based on low‐quality available evidence. Herein, we share our experience with a case series, and propose a protocol regarding the management of dental patients taking DOACs. (Source: Oral Diseases)
Source: Oral Diseases - February 26, 2018 Category: ENT & OMF Authors: Y Hassona, D Malamos, M Shaqman, Z Baqain, C Scully Tags: PROF SCULLY MEMORIAL ISSUE Source Type: research
Role of tissue ‐specific steroid metabolism in oral disease: Is there any clinical implication?
The discovery of an oral glucocorticoid system has provided novel conceptual frameworks for understanding the effects of endogenous and exogenous corticosteroids in the oral cavity. For example, liquorice derivatives have long been used in the treatment of oral inflammatory conditions and it is now known that a chief constituent of liquorice root, glycyrrhetinic acid, inhibits 11β‐hydroxysteroid dehydrogenase (11β‐HSD) type 2 thus increasing local cortisol levels. Hence, targeting the local interconversion between inactive cortisone and active cortisol by 11β‐HSD inhibitors/activators offers potentially advantageo...
Source: Oral Diseases - February 26, 2018 Category: ENT & OMF Authors: N Cirillo Tags: PROF SCULLY MEMORIAL ISSUE Source Type: research
Oral manifestation of systemic diseases —a perspective from an oral pathology diagnostic service
(Source: Oral Diseases)
Source: Oral Diseases - February 26, 2018 Category: ENT & OMF Authors: G Bradley, MA Magalhaes Tags: PROF SCULLY MEMORIAL ISSUE Source Type: research
Can atrophic ‐erosive oral lichen planus promote cardiovascular diseases? A population‐based study
ConclusionPatients with RL could possibly have a higher risk of developing ACS. Further analysis on larger cohort is however warranted. (Source: Oral Diseases)
Source: Oral Diseases - February 26, 2018 Category: ENT & OMF Authors: D Conrotto, R Barattero, M Carbone, A Gambino, V Sciannameo, F Ricceri, F Conrotto, R Broccoletti, P ‐G Arduino Tags: PROF SCULLY MEMORIAL ISSUE Source Type: research
Human papillomavirus load in benign HPV ‐associated oral lesions from HIV/AIDS individuals
ConclusionsMultiple HPV‐OLs showed high HPV loads, possibly indicating transcriptional activity of the virus; however, in the HIV setting, the individual and local immunological response could be the key process. (Source: Oral Diseases)
Source: Oral Diseases - February 26, 2018 Category: ENT & OMF Authors: S Camacho ‐Aguilar, V Ramírez‐Amador, P Rosendo‐Chalma, M Guido‐Jiménez, A García‐Carrancá, G Anaya‐Saavedra Tags: PROF SCULLY MEMORIAL ISSUE Source Type: research
Breast cancer patients have increased risk of developing mTOR inhibitor ‐associated stomatitis
This study emphasizes the high prevalence of mIAS in patients using everolimus, in particular, in patients with breast cancer. (Source: Oral Diseases)
Source: Oral Diseases - February 26, 2018 Category: ENT & OMF Authors: MHA Lima, GNM Hajj, VCC Lima, FA Alves Tags: PROF SCULLY MEMORIAL ISSUE Source Type: research
Lyophilized bone marrow cell extract functionally restores irradiation ‐injured salivary glands
ConclusionLyophilization of BMCE maintained its bioactivity and therapeutic effect on irradiation‐injured salivary glands. The advantages of freeze‐drying BMCE are its storage and transport at ambient temperature. (Source: Oral Diseases)
Source: Oral Diseases - February 26, 2018 Category: ENT & OMF Authors: X Su, D Fang, Y Liu, G Ruan, J Seuntjens, JM Kinsella, SD Tran Tags: PROF SCULLY MEMORIAL ISSUE Source Type: research
