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Long-term Outcome after Percutaneous Coronary Intervention Compared with Minimally Invasive Coronary Artery Bypass Surgery in the Elderly.
CONCLUSION: Among elderly patients, long-term all-cause mortality is similar after PCI and MICS-CABG. However, there is a significantly higher rate of repeat revascularization after PCI. PMID: 27014373 [PubMed] (Source: Open Cardiovascular Medicine Journal)
Source: Open Cardiovascular Medicine Journal - March 27, 2016 Category: Cardiology Tags: Open Cardiovasc Med J Source Type: research

High-altitude Pulmonary Hypertension: an Update on Disease Pathogenesis and Management.
Authors: Mirrakhimov AE, Strohl KP Abstract High-altitude pulmonary hypertension (HAPH) affects individuals residing at altitudes of 2,500 meters and higher. Numerous pathogenic variables play a role in disease inception and progression and include low oxygen concentration in inspired air, vasculopathy, and metabolic abnormalities. Since HAPH affects only some people living at high altitude genetic factors play a significant role in its pathogenesis. The clinical presentation of HAPH is nonspecific and includes fatigue, shortness of breath, cognitive deficits, cough, and in advanced cases hepatosplenomegal...
Source: Open Cardiovascular Medicine Journal - March 27, 2016 Category: Cardiology Tags: Open Cardiovasc Med J Source Type: research

Pseudomonas aeruginosa Infective Endocarditis Following Aortic Valve Implantation: A Note of Caution.
We report a case of PVE due to Pseudomonas aeruginosa after TAVI that required SAVR, with successful outcome. PVE usually occurs during the first year after TAVI and entails a high mortality risk because patients eligible for this min-imally invasive procedure are fragile (i.e. advanced age and/or severe comorbidities). Additionally, clinical presentation may be atypical or subtle and transesophageal echocardiogram (TEE) may not be conclusive, which delays diagnosis and treatment worsening the prognosis. This case highlights that open SAVR might be ultimately indicated as part of treatment for TAVI-PVE despite a high-risk ...
Source: Open Cardiovascular Medicine Journal - March 27, 2016 Category: Cardiology Tags: Open Cardiovasc Med J Source Type: research

6th Hellenic Congress in Athens, of the Hellenic Atherosclerosis Society, on the 04-06 December 2014 Novel Pharmacologic Treatments of Familial Hypercholesterolaemia.
Authors: Vg A Abstract Familial hypercholesterolaemia (FH) is the most common inherited monogenic lipid disorder. It is caused by mutations of genes related to low density lipoprotein (LDL) receptors, apolipoprotein B or proprotein convertase subtilisin/kexin type 9 (PCSK9). Homozygous FH (HoFH; 1/400,000 births) is treated by LDL apheresis. Recently lomitapide has been used for the treatment of HoFH as a monotherapy or in addition to LDL apheresis. Heterozygous FH (HeFH), 1/250-1/200 births, is associated with an increased cardiovascular disease (CVD) risk. The main treatment for HeFH has been high doses ...
Source: Open Cardiovascular Medicine Journal - December 18, 2015 Category: Cardiology Tags: Open Cardiovasc Med J Source Type: research

Long-term Effect of Optimized Sedation and Pain Management after Sudden Cardiac Arrest.
CONCLUSION: Our results demonstrate a long-term reduction of mechanical ventilation time and ICU length of stay achieved by implementation of an individual sedation management. This suggests sedation guidelines as effective tools to reduce the mechanical ventilation time and ICU length of stay in patients after sudden cardiac arrest in ST-elevated myocardial infarction. Investigations with a larger patient number and higher statistical power are required to confirm these findings. PMID: 26664658 [PubMed] (Source: Open Cardiovascular Medicine Journal)
Source: Open Cardiovascular Medicine Journal - December 18, 2015 Category: Cardiology Tags: Open Cardiovasc Med J Source Type: research

Evaluation of Glycemia Control Achieved by Glargine and Lispro Versus Detemir and Aspart Insulin Regimes in Type 2 Diabetics Undergoing Surgery.
This study has evaluated the clinical outcome of two subcutaneous split-mixed Glargine+Lispro and Detemir+Aspart insulin regimes in type 2 diabetics undergoing surgery. PMID: 26312079 [PubMed - as supplied by publisher] (Source: Open Cardiovascular Medicine Journal)
Source: Open Cardiovascular Medicine Journal - August 28, 2015 Category: Cardiology Tags: Open Cardiovasc Med J Source Type: research

Effects of Bileaflet Mechanical Mitral Valve Rotational Orientation on Left Ventricular Flow Conditions.
Authors: Westerdale JC, Adrian R, Squires K, Chaliki H, Belohlavek M Abstract We studied left ventricular flow patterns for a range of rotational orientations of a bileaflet mechanical heart valve (MHV) implanted in the mitral position of an elastic model of a beating left ventricle (LV). The valve was rotated through 3 angular positions (0, 45, and 90 degrees) about the LV long axis. Ultrasound scans of the elastic LV were obtained in four apical 2-dimensional (2D) imaging projections, each with 45 degrees of separation. Particle imaging velocimetry was performed during the diastolic period to quantify th...
Source: Open Cardiovascular Medicine Journal - August 28, 2015 Category: Cardiology Tags: Open Cardiovasc Med J Source Type: research

Blunt Thoracic Aortic Injuries: New Perspectives in Management.
We present a mini-review of the most recent relevant literature that briefly describes the major shifts in the diagnosis and treatment of BTAIs and compares the outcomes of the conventional surgical approach to those of the endovascular method for the definitive repair of these injuries. Although both the reviewed literature and the most recently published guidelines are in support of the use of the endovascular approach, as short and midterm results are promising, its long-term outcomes still remain in question. PMID: 26312081 [PubMed - as supplied by publisher] (Source: Open Cardiovascular Medicine Journal)
Source: Open Cardiovascular Medicine Journal - August 28, 2015 Category: Cardiology Tags: Open Cardiovasc Med J Source Type: research

Tricuspid valve regurgitation following temporary or permanent endocardial lead insertion, and the impact of cardiac resynchronization therapy.
CONCLUSION: Permanent endocardial lead implantation was associated with an increase in TR; however, patients who underwent device implantation with CRT did not have an increase in TR.Temporary lead insertion during ablation was not associated with changes in the degree of TR. A large, prospective study is needed to accurately define the incidence and exact mechanisms of permanent endocardial lead-related TR. PMID: 25674163 [PubMed] (Source: Open Cardiovascular Medicine Journal)
Source: Open Cardiovascular Medicine Journal - June 3, 2015 Category: Cardiology Tags: Open Cardiovasc Med J Source Type: research

HEALS Hypertension Control Program: Training Church Members as Program Leaders.
CONCLUSION: Church-based culturally modified health promotion interventions conducted by the community lay members may be a way to reduce health disparities in ethnic minorities. PMID: 25685245 [PubMed] (Source: Open Cardiovascular Medicine Journal)
Source: Open Cardiovascular Medicine Journal - June 3, 2015 Category: Cardiology Tags: Open Cardiovasc Med J Source Type: research

Evidence for an association between tako-tsubo cardiomyopathy and bronchial asthma: retrospective analysis in a primary care hospital.
CONCLUSION: Prevalence of asthma was significantly higher in patients with TTS compared to epidemiologic data from an age-matched population. Phenotypes of patients developing obstructive ventilatory disease and TTS might share common pathogenic mechanisms beyond the use of bronchodilatators. In addition, we identified other iatrogenic etiologies in patients with TTS. PMID: 25767631 [PubMed] (Source: Open Cardiovascular Medicine Journal)
Source: Open Cardiovascular Medicine Journal - June 3, 2015 Category: Cardiology Tags: Open Cardiovasc Med J Source Type: research

Association of high blood pressure with body mass index, smoking and physical activity in healthy young adults.
CONCLUSION: BMI was significantly and directly associated with resting BP in both sexes. Smoking prevalence and PA status were not associated with BP in this sample of Greek young adults. PMID: 25834651 [PubMed] (Source: Open Cardiovascular Medicine Journal)
Source: Open Cardiovascular Medicine Journal - June 3, 2015 Category: Cardiology Tags: Open Cardiovasc Med J Source Type: research

Local use of ankaferd blood clotter in emergent beating heart coronary artery bypass grafting.
CONCLUSION: Our study showed that the local use of 10 mL ABC reduces bleeding significantly. Therefore, transfusion requirements of PRBC, platelets, and total blood units in patients on clopidogrel and ASA undergoing emergent beating heart CABG. To provide cardiac tamponade because of excessive mediastinal bleeding and requirement of blood transfusion after emergent CABG patients who previously administered clopidogrel and ASA, we propose local use of ABC solution as a potent coagulant agent. PMID: 25834652 [PubMed] (Source: Open Cardiovascular Medicine Journal)
Source: Open Cardiovascular Medicine Journal - June 3, 2015 Category: Cardiology Tags: Open Cardiovasc Med J Source Type: research

Body Surface Mapping of T-wave Alternans Depends on the Distribution of Myocardial Scarring.
Authors: Zeller A, Ghoraani B Abstract T-Wave alternans (TWA) testing using 12-lead electrocardiogram/Frank leads is emerging as an important non-invasive biomarker to identify patients at high risk of Sudden Cardiac Death (SCD). Cardiac scarring is very common among cardiomyopathy patients; however, its influence on the body surface distribution of TWA has not yet been defined. Our objective was to perform a simulation study in order to determine whether cardiac scarring affects the distribution of TWA on thorax such that the standard leads fail to detect TWA in some of cardiomyopathy patients; thereby pr...
Source: Open Cardiovascular Medicine Journal - June 3, 2015 Category: Cardiology Tags: Open Cardiovasc Med J Source Type: research

Cardiovascular Risk Assessment and Effects on Behavior in Switzerland The Swiss Heart Foundation HerzCheck(®)/Cardio-Test(®).
CONCLUSION: The overall cardiovascular risk of individuals participating in a pharmacy based risk assessment program seems to be low. CardioTest (®) provided risk stratification with respect to future cardio-vascular events. CardioTest (®) seems to have impact on individual behavior and lifestyle modification. Other settings and locations for screening might be considered to reach higher risk individuals at an earlier stage. PMID: 25834654 [PubMed] (Source: Open Cardiovascular Medicine Journal)
Source: Open Cardiovascular Medicine Journal - June 3, 2015 Category: Cardiology Tags: Open Cardiovasc Med J Source Type: research