Allogeneic Blood Product Usage in Coronary Artery Bypass Grafting (CABG) with minimalized Extracorporeal Circulation System (MECC) Versus Standard On-Pump Coronary Artery Bypass Grafting.
CONCLUSION: Application of MECC as on-pump coronary artery bypass graft (CABG) results in significantly lower ABPT as well as shorter ICU and in-hospital stay. In order to achieve these benefits of MECC autologous retrograde priming, Bispectral index (BIS) monitoring, intraoperative cell salvage, meticulous hemostasis and strict peri- and postoperative volume management are crucial. PMID: 27499818 [PubMed] (Source: Open Cardiovascular Medicine Journal)
Source: Open Cardiovascular Medicine Journal - August 9, 2016 Category: Cardiology Tags: Open Cardiovasc Med J Source Type: research

Prevalence of Major Cardiovascular Risk Factors and Coronary Heart Disease in a Sample of Greek Adults: The Saronikos Study.
CONCLUSION: Classic risk factors are highly prevalent and frequently clustered, especially in adults aged 50 years and older. These findings raise concerns about future trends of already increased rates of CHD. Multifactorial and integrated population-based interventions need to be applied to reduce the burden of cardiovascular conditions. PMID: 27429668 [PubMed] (Source: Open Cardiovascular Medicine Journal)
Source: Open Cardiovascular Medicine Journal - July 20, 2016 Category: Cardiology Tags: Open Cardiovasc Med J Source Type: research

Aortic Wall Extracellular Matrix Proteins Correlate with Syntax Score in Patients Undergoing Coronary Artery Bypass Surgery.
CONCLUSION: This study shows that aortic extracellular matrix (ECM) differ between High and Low syntax groups with up-regulation of Collagen I and Elastin level in High Syntax Score group. This identifies aortic punches collected during CABG as another biomarker source related with atherosclerosis severity and possible clinical outcome. PMID: 27347220 [PubMed] (Source: Open Cardiovascular Medicine Journal)
Source: Open Cardiovascular Medicine Journal - June 29, 2016 Category: Cardiology Tags: Open Cardiovasc Med J Source Type: research

Does Stroke Volume Increase During an Incremental Exercise? A Systematic Review.
CONCLUSION: The stroke volume are unclear, include contradictory evidence. Additional studies with standardized reporting for subjects (e.g., age, gender, physical fitness, and body position), exercise test protocols, and left ventricular function are required to clarify the characteristics of stroke volume during incremental maximal-exercise load. PMID: 27347221 [PubMed] (Source: Open Cardiovascular Medicine Journal)
Source: Open Cardiovascular Medicine Journal - June 29, 2016 Category: Cardiology Tags: Open Cardiovasc Med J Source Type: research

Is There an Association Between Carotid-Femoral Pulse Wave Velocity and Coronary Heart Disease in Patients with Coronary Artery Disease: A Pilot Study.
Authors: Katsiki N, Kollari E, Dardas S, Dardas P, Haidich AB, Athyros VG, Karagiannis A Abstract Arterial stiffness has been shown to predict cardiovascular morbidity and mortality. Carotid-femoral pulse wave velocity (cfPWV) is regarded the gold standard marker of arterial stiffness. In previous studies, cfPWV was associated with the presence of coronary heart disease (CHD). However, with regard to CHD severity as assessed by the Syntax Score, only brachial-ankle PWV was reported to correlate with Syntax Score; no data exist for cfPWV. In this pilot study, we evaluated the possible associations between c...
Source: Open Cardiovascular Medicine Journal - June 29, 2016 Category: Cardiology Tags: Open Cardiovasc Med J Source Type: research

Neurocardiology.
Authors: Khan M PMID: 27347223 [PubMed] (Source: Open Cardiovascular Medicine Journal)
Source: Open Cardiovascular Medicine Journal - June 29, 2016 Category: Cardiology Tags: Open Cardiovasc Med J Source Type: research

An Overview of Cardiac Management in Neuromuscular Disease.
Authors: Hickey RM, Cullen JD, Sachs GM Abstract Muscular dystrophy and myasthenia gravis are two neuromuscular disorders that can involve significant cardiovascular complications. The frequency and severity of cardiac pathology varies widely among the muscular dystrophies. In some, it is nearly inevitable and requires regular evaluation. In others, assessment of cardiac function can be more symptom-driven. On-ly a minority of myasthenic patients manifest disease-related cardiovascular complications; however, their presentation can be rapidly progressive and life-threatening.. PMID: 27347224 [PubM...
Source: Open Cardiovascular Medicine Journal - June 29, 2016 Category: Cardiology Tags: Open Cardiovasc Med J Source Type: research

Long-term Arrhythmia Monitoring in Cryptogenic Stroke: Who, How, and for How Long?
Authors: Montalvo M, Ali R, Silver B, Khan M Abstract Cryptogenic stroke and transient ischemic attack (TIA) account for approximately one-third of stroke patients [1]. Paroxys-mal atrial fibrillation (PAF) has been suggested as a major etiology of these cryptogenic strokes [2, 3]. PAF can be difficult to diagnose because it is intermittent, often brief, and asymptomatic. PAF might be more prevalent than persistent atrial fibrillation in stroke and TIA patients, especially in younger populations [4, 5]. In patients with atrial fibrillation, anticoagulation provides significant risk reduction [6]. A new gen...
Source: Open Cardiovascular Medicine Journal - June 29, 2016 Category: Cardiology Tags: Open Cardiovasc Med J Source Type: research

Newer Oral Anticoagulants: Stroke Prevention and Pitfalls.
Authors: Patel A, Goddeau RP, Henninger N Abstract Warfarin is very effective in preventing stroke in patients with atrial fibrillation. However, its use is limited due to fear of hemorrhagic complications, unpredictable anticoagulant effects related to multiple drug interactions and dietary restrictions, a narrow therapeutic window, frequent difficulty maintaining the anticoagulant effect within a narrow therapeutic window, and the need for inconvenient monitoring. Several newer oral anticoagulants have been approved for primary and secondary prevention of stroke in patients with non-valvular atrial fibri...
Source: Open Cardiovascular Medicine Journal - June 29, 2016 Category: Cardiology Tags: Open Cardiovasc Med J Source Type: research

Ictal Cardiac Ryhthym Abnormalities.
Authors: Ali R Abstract Cardiac rhythm abnormalities in the context of epilepsy are a well-known phenomenon. However, they are under-recognized and often missed. The pathophysiology of these events is unclear. Bradycardia and asystole are preceded by seizure onset suggesting ictal propagation into the cortex impacting cardiac autonomic function, and the insula and amygdala being possible culprits. Sudden unexpected death in epilepsy (SUDEP) refers to the unanticipated death of a patient with epilepsy not related to status epilepticus, trauma, drowning, or suicide. Frequent refractory generalized tonic-clon...
Source: Open Cardiovascular Medicine Journal - June 29, 2016 Category: Cardiology Tags: Open Cardiovasc Med J Source Type: research

Stroke Prevention in Atrial Fibrillation and Valvular Heart Disease.
Authors: Ahmad S, Wilt H Abstract There is a clinically staggering burden of disease stemming from cerebrovascular events, of which a majority are ischemic in nature and many are precipitated by atrial fibrillation (AF). AF can occur in isolation or in association with myocardial or structural heart disease. In the latter case, and when considering health at an international level, congenital and acquired valve-related diseases are frequent contributors to the current pandemic of AF and its clinical impact. Guidelines crafted by the American Heart Association, American College of Cardiology, European Socie...
Source: Open Cardiovascular Medicine Journal - June 29, 2016 Category: Cardiology Tags: Open Cardiovasc Med J Source Type: research

Association Between ACE Gene Polymorphism and QT Dispersion in Patients with Acute Myocardial Infarction.
CONCLUSION: Carriers of the D allele of ACE gene I/D polymorphism may be associated with QT dispersion prolongation in patients with MI.An interaction of QT dispersion and ACE gene polymorphism may be associated with an elevation of serum type I-C terminal pro-collagen concentration, possibly leading to myocardial fibrosis, and increased action potential duration. PMID: 27347229 [PubMed] (Source: Open Cardiovascular Medicine Journal)
Source: Open Cardiovascular Medicine Journal - June 29, 2016 Category: Cardiology Tags: Open Cardiovasc Med J Source Type: research

Correlations Between Cardiovascular Autonomic Control Indices During the Two-hour Immobilization Test in Healthy Subjects.
CONCLUSION: Cardiovascular autonomic control is characterized by a pronounced variability among healthy subjects and stability in time in each subject. We have not found any regularity in variation of cardiovascular autonomic indices, which is common for the entire group of healthy subjects during the two-hour immobilization test. Mean HR is a summary index of efficiency of heart autonomic control. Index S is the most independent cardiovascular autonomic parameter. PMID: 27053965 [PubMed] (Source: Open Cardiovascular Medicine Journal)
Source: Open Cardiovascular Medicine Journal - April 8, 2016 Category: Cardiology Tags: Open Cardiovasc Med J Source Type: research

A Peculiar Case of a Floating Angio-Seal.
CONCLUSION: Vascular complications, such as lower limb ischemia, requiring surgical intervention tend to be higher after use of a vascular closure device. We advise routine physical examination of the puncture site after percutaneous closure with a vascular closure device, such as an Angio-Sealâ„¢. The removal of the device can be performed via an open or endoscopic approach, based on available experience. PMID: 27053966 [PubMed] (Source: Open Cardiovascular Medicine Journal)
Source: Open Cardiovascular Medicine Journal - April 8, 2016 Category: Cardiology Tags: Open Cardiovasc Med J Source Type: research

Testosterone and Cardiovascular Disease.
Authors: Tambo A, Roshan MH, Pace NP Abstract Cardiovascular disease [CVD] is a leading cause of mortality accounting for a global incidence of over 31%. Atherosclerosis is the primary pathophysiology underpinning most types of CVD. Historically, modifiable and non-modifiable risk factors were suggested to precipitate CVD. Recently, epidemiological studies have identified emerging risk factors including hypotestosteronaemia, which have been associated with CVD. Previously considered in the realms of reproductive biology, testosterone is now believed to play a critical role in the cardiovascular system in h...
Source: Open Cardiovascular Medicine Journal - March 27, 2016 Category: Cardiology Tags: Open Cardiovasc Med J Source Type: research