Information-theoretic approach to detect directional information flow in EEG signals induced by TMS
This study evaluates two methods for effective connectivity analysis, symbolic transfer entropy (STE) and vector autoregression (VAR), by applying them to TMS-EEG data. In terms of the consistency of results from different experimental sessions, STE is found to yield robust results irrespective of sessions, whereas VAR produces less correlation between sessions. Furthermore, STE preferentially detects the directional information flow from the TMS target. Taken together, our results suggest that STE is a reliable method for detecting the effect of TMS, implying that it would also be useful for identifying neural activity du...
Source: Neuroscience Research - September 15, 2019 Category: Neuroscience Source Type: research
miR-101 down-regulates mTOR expression and attenuates neuropathic pain in chronic constriction injury rat models
In conclusion, miR-101 had neuropathic pain-attenuating activity through targeting mTOR. (Source: Neuroscience Research)
Source: Neuroscience Research - September 15, 2019 Category: Neuroscience Source Type: research
Nandrolone improve synaptic plasticity at the hippocampus CA1 area and spatial localization in the Morris water maze of male adolescent rats
Publication date: Available online 6 September 2019Source: Neuroscience ResearchAuthor(s): Salimi Zahra, Khajehpour Lotfollah, Moradpour Farshad, Moazedi Ahmad Ali, Pourmotabbed Ali, Zarei FatemehAbstractNandrolone is the most popular compound that are mainly abused. Experimental studies have reported that administration of nandrolone affects cognitive performance. So, the aim of this study is to evaluate the effect of nandrolone on spatial localization and synaptic plasticity of male adolescent rats. Experimantal groups received DMSO and nandrolone (10, 30 and 60 µg, i.c.v.). Another aim is to evaluate the role of cast...
Source: Neuroscience Research - September 6, 2019 Category: Neuroscience Source Type: research
Recency memory effects in Macaques during sequential delayed match-to-sample task with visual noise
Publication date: Available online 21 August 2019Source: Neuroscience ResearchAuthor(s): Ryosuke Kuboki, Narihisa Matsumoto, Yasuko Sugase-Miyamoto, Tsuyoshi Setogawa, Barry. J. Richmond, Munetaka ShidaraAbstractVisual object recognition requires both visual sensory information and memory, and its mechanisms are often studied using old-world monkeys. Wittig et al. (2014, 2016) reported that Rhesus monkeys and humans seem to adopt different strategies in a short-term visual memory task. The Rhesus monkeys seemed to rely on recency of stimulus repetition, whereas humans relied on specific memorization. We conducted experimen...
Source: Neuroscience Research - August 22, 2019 Category: Neuroscience Source Type: research
Can krill oil be of use for counteracting neuroinflammatory processes induced by high fat diet and aging?
Publication date: Available online 22 August 2019Source: Neuroscience ResearchAuthor(s): John M. Andraka, Naveen Sharma, Yannick MarchalantAbstractMost neurodegenerative diseases, such as Alzheimer’s and Parkinson’s disease, demonstrate preceding or on-going inflammatory processes. Therefore, discovering effective means of counteracting detrimental inflammatory mediators in the brain could help alter aging-related disease onset and progression. Fish oil and marine-derived omega-3, long-chain polyunsaturated fatty acids (LC n-3) have shown promising anti-inflammatory effects both systemically and centrally. More specifi...
Source: Neuroscience Research - August 22, 2019 Category: Neuroscience Source Type: research
Prelim ii(edi board)
Publication date: October 2019Source: Neuroscience Research, Volume 147Author(s): (Source: Neuroscience Research)
Source: Neuroscience Research - August 22, 2019 Category: Neuroscience Source Type: research
Sex differences in the effect of acute administration of nicotine on MRS-measured metabolic profile of the rat brain
Publication date: Available online 2 August 2019Source: Neuroscience ResearchAuthor(s): Serguei Liachenko, Jaivijay RamuAbstractWomen are less able to stop smoking than men. Elucidation of sex differences in the tobacco addiction could facilitate personalized treatment. Specialized brain reward systems are controlling the behavior through reinforcement using specific neuromediators. Using non-invasive magnetic resonance spectroscopy (MRS) to ascertain addiction/harm biomarkers could lead to better management of public health through advancements in regulatory and translational research. Proton MRS was used to monitor chang...
Source: Neuroscience Research - August 4, 2019 Category: Neuroscience Source Type: research
Prelim ii(edi board)
Publication date: September 2019Source: Neuroscience Research, Volume 146Author(s): (Source: Neuroscience Research)
Source: Neuroscience Research - July 25, 2019 Category: Neuroscience Source Type: research
A PRIMPOL mutation and variants in multiple genes may contribute to phenotypes in a familial case with chronic progressive external ophthalmoplegia symptoms
Publication date: Available online 23 July 2019Source: Neuroscience ResearchAuthor(s): Kei Kasamo, Masayuki Nakamura, Yoko Daimou, Akira SanoAbstractChronic progressive external ophthalmoplegia (CPEO) is one of the most common mitochondrial disorders. It is characterized by bilateral, slowly progressing loss of extraocular muscle mobility, orbicularis oculi weakness, ptosis, and other neuromuscular symptoms, which are caused by the accumulation of multiple mitochondrial DNA (mtDNA) deletions. Many mutations in different nuclear genes, such as POLG1, POLG2, ANT1, and others, have been described as causing autosomal-inherite...
Source: Neuroscience Research - July 24, 2019 Category: Neuroscience Source Type: research
Docosahexaenoic acid ameliorates traumatic brain injury involving JNK-mediated Tau phosphorylation signaling
Publication date: Available online 23 July 2019Source: Neuroscience ResearchAuthor(s): Wei Zhu, Li Zhao, Tuo Li, Hao Xu, Yuexia Ding, Guangqiang CuiAbstractHyperphosphorylation of Tau has been found in patients with traumatic brain injury (TBI). Inhibition of c-Jun N-terminal kinases (JNKs) improves neurological function by suppressing Tau phosphorylation. By inhibiting JNK, docosahexaenoic acid (DHA) protects against cognitive decline in a mouse model of Alzheimer’s disease (AD). We hypothesize that DHA protects against neuronal damage and behavioral deficits by inhibition of JNK mediated Tau phosphorylation. We induced...
Source: Neuroscience Research - July 24, 2019 Category: Neuroscience Source Type: research
Reactive astrocytes increase expression of proNGF in the mouse model of contused spinal cord injury
This study demonstrated that reactive astrocytes increased proNGF expression after spinal cord injury, also suggesting involvement of exosome-like proNGF transport or release in triggering neuronal apoptosis and aggravating progression of spinal cord injury. (Source: Neuroscience Research)
Source: Neuroscience Research - July 24, 2019 Category: Neuroscience Source Type: research
Abnormal organization during neurodevelopment in a mouse model of Sandhoff disease
This study investigated early neurodevelopment in vivo using Hexb−/− mice. The structure of adult cerebral cortices of Hexb−/− mice was normal. However, the expression of Sox2, an NSC-related gene, was reduced in the embryonic cerebral cortices of Hexb−/− mice. Moreover, a reduction of early neuronal migration and differentiation was observed in the embryonic cerebral cortices of Hexb−/− mice. In addition, we showed that the production of layer-specific neurons was delayed in somatosensory cerebral cortices of Hexb−/− mice. These findings suggest that the alterations observed in embryonic Hexb−/− mi...
Source: Neuroscience Research - July 22, 2019 Category: Neuroscience Source Type: research
Proprioception: Bottom-up directive for motor recovery after spinal cord injury
Publication date: Available online 20 July 2019Source: Neuroscience ResearchAuthor(s): Aya TakeokaAbstractProprioceptive feedback provides movement-matched sensory information essential for motor control and recovery after spinal cord injury. While it is understood that the fundamental contribution of proprioceptive feedback circuits in locomotor recovery is to activate the local spinal cord interneurons and motor neurons in a context-dependent manner, the precise mechanisms by which proprioception enables motor recovery after a spinal cord injury remain elusive. Furthermore, how proprioception contributes to motor learnin...
Source: Neuroscience Research - July 21, 2019 Category: Neuroscience Source Type: research
Dissociation between schizophrenia-relevant behavioral profiles and volumetric brain measures after long-lasting social isolation in Roman rats
Publication date: Available online 12 July 2019Source: Neuroscience ResearchAuthor(s): A. Sánchez-González, I. Oliveras, C. Río-Álamos, MA. Piludu, C. Gerbolés, C. Tapias-Espinosa, A. Tobeña, S. Aznar, A. Fernández-TeruelABSTRACTSocial isolation rearing of rodents is an environmental manipulation known to induce or potentiate psychotic-like symptoms and attentional and cognitive impairments relevant for schizophrenia. When subjected to a 28-week isolation rearing treatment, the Roman high-avoidance (RHA-I) rats display the common behavioral social isolation syndrome, with prepulse inhibition (PPI) deficits, hyperact...
Source: Neuroscience Research - July 13, 2019 Category: Neuroscience Source Type: research
Methylenedioxypyrovalerone (MDPV) impairs working memory and alters patterns of dopamine signaling in mesocorticolimbic substrates
Publication date: Available online 11 July 2019Source: Neuroscience ResearchAuthor(s): David L. Bernstein, Sunyl U. Nayak, Chicora F. Oliver, Scott M. Rawls, Slava RomAbstractKnowledge remains limited about how chronic cathinone exposure impacts dopamine systems in brain reward circuits. In the present study, a binge-like MDPV exposure that impaired novel object recognition (NOR) dysregulated dopamine markers in mesocorticolimbic substrates of rats, with especially profound effects on D1 and D2 receptor’s and VMAT gene expression. Our data suggested that dopamine receptivity was reduced in the NAc but increased in the PF...
Source: Neuroscience Research - July 12, 2019 Category: Neuroscience Source Type: research
