Genome watch: Klebsiella pneumoniae: when a colonizer turns bad
Nature Reviews Microbiology 15, 384 (2017).
doi:10.1038/nrmicro.2017.64
Authors: Matthew J. Dorman & Francesca L. Short
This month's Genome Watch highlights how whole-genome sequencing (WGS) and epidemiological studies can be combined to explore the link between colonization and infection by Klebsiella pneumoniae in patients who are hospitalized. (Source: Nature Reviews Microbiology)
Source: Nature Reviews Microbiology - June 5, 2017 Category: Microbiology Authors: Matthew J. Dorman Francesca L. Short Tags: News and Analysis Source Type: research
Bacterial physiology: An inside job on metabolism
Nature Reviews Microbiology 15, 383 (2017).
doi:10.1038/nrmicro.2017.68
Author: Ashley York
Two new studies reveal how Mycobacterium tuberculosis adapts to environmental stresses that are associated with an intracellular lifestyle. (Source: Nature Reviews Microbiology)
Source: Nature Reviews Microbiology - June 5, 2017 Category: Microbiology Authors: Ashley York Tags: Research Highlight Source Type: research
Bacterial evolution: The origins of pathogenic enterococci
This study investigates the origins of multidrug-resistant pathogenic enterococci. (Source: Nature Reviews Microbiology)
Source: Nature Reviews Microbiology - June 5, 2017 Category: Microbiology Authors: Shimona Starling Tags: Research Highlight Source Type: research
Pathways to zoonotic spillover
Nature Reviews Microbiology 15, 502 (2017).
doi:10.1038/nrmicro.2017.45
Authors: Raina K. Plowright, Colin R. Parrish, Hamish McCallum, Peter J. Hudson, Albert I. Ko, Andrea L. Graham & James O. Lloyd-Smith
Zoonotic spillover, which is the transmission of a pathogen from a vertebrate animal to a human, presents a global public health burden but is a poorly understood phenomenon. Zoonotic spillover requires several factors to align, including the ecological, epidemiological and behavioural determinants of pathogen exposure, (Source: Nature Reviews Microbiology)
Source: Nature Reviews Microbiology - May 30, 2017 Category: Microbiology Authors: Raina K. Plowright Colin R. Parrish Hamish McCallum Peter J. Hudson Albert I. Ko Andrea L. Graham James O. Lloyd-Smith Tags: Perspectives Source Type: research
Bacterial pathogenesis: Campylobacter follows the clues
Nature Reviews Microbiology 15, 382 (2017).
doi:10.1038/nrmicro.2017.63
Author: Irene Vacca
Luethy et al. show that metabolites produced by the gut microbiota can modulate the expression of Campylobacter jejuni determinants that are required for growth, commensalism and virulence. (Source: Nature Reviews Microbiology)
Source: Nature Reviews Microbiology - May 30, 2017 Category: Microbiology Authors: Irene Vacca Tags: Research Highlight Source Type: research
Viral evolution: Zika is on point to increase spread
This study suggests that the valine residue at position 188 of NS1 has a crucial role in antigenaemia, which is essential for the transmission of Zika virus from mammalian hosts to mosquitoes. (Source: Nature Reviews Microbiology)
Source: Nature Reviews Microbiology - May 30, 2017 Category: Microbiology Authors: Andrea Du Toit Tags: Research Highlight Source Type: research
Anticancer effects of the microbiome and its products
Nature Reviews Microbiology 15, 465 (2017).
doi:10.1038/nrmicro.2017.44
Authors: Laurence Zitvogel, Romain Daillère, María Paula Roberti, Bertrand Routy & Guido Kroemer
The human gut microbiome modulates many host processes, including metabolism, inflammation, and immune and cellular responses. It is becoming increasingly apparent that the microbiome can also influence the development of cancer. In preclinical models, the host response to cancer treatment has been improved by modulating (Source: Nature Reviews Microbiology)
Source: Nature Reviews Microbiology - May 22, 2017 Category: Microbiology Authors: Laurence Zitvogel Romain Daill è re Mar í a Paula Roberti Bertrand Routy Guido Kroemer Tags: Review Source Type: research
Persistent bacterial infections and persister cells
Nature Reviews Microbiology 15, 453 (2017).
doi:10.1038/nrmicro.2017.42
Authors: Robert A. Fisher, Bridget Gollan & Sophie Helaine
Many bacteria can infect and persist inside their hosts for long periods of time. This can be due to immunosuppression of the host, immune evasion by the pathogen and/or ineffective killing by antibiotics. Bacteria can survive antibiotic treatment if they are resistant or tolerant to (Source: Nature Reviews Microbiology)
Source: Nature Reviews Microbiology - May 22, 2017 Category: Microbiology Authors: Robert A. Fisher Bridget Gollan Sophie Helaine Tags: Review Source Type: research
Mechanisms of gene flow in archaea
Nature Reviews Microbiology 15, 492 (2017).
doi:10.1038/nrmicro.2017.41
Authors: Alexander Wagner, Rachel J. Whitaker, David J. Krause, Jan-Hendrik Heilers, Marleen van Wolferen, Chris van der Does & Sonja-Verena Albers
Archaea are diverse, ecologically important, single-celled microorganisms. They have unique functions and features, such as methanogenesis and the composition of their cell envelope, although many characteristics are shared with the other domains of life, either through ancestry or through promiscuous horizontal gene transfer. The exchange (Source: Nature Reviews Microbiology)
Source: Nature Reviews Microbiology - May 15, 2017 Category: Microbiology Authors: Alexander Wagner Rachel J. Whitaker David J. Krause Jan-Hendrik Heilers Marleen van Wolferen Chris van der Does Sonja-Verena Albers Tags: Review Source Type: research
Corrigendum: Assembly, structure, function and regulation of type III secretion systems
Nature Reviews Microbiology 15, 379 (2017).
doi:10.1038/nrmicro.2017.54
Author: Wanyin Deng, Natalie C. Marshall, Jennifer L. Rowland, James M. McCoy, Liam J. Worrall, Andrew S. Santos, Natalie C. J. Strynadka & B. Brett Finlay
Nature Reviews Microbiology15,
323–33710.1038/nrmicro.2017.20(2017)In the above article, a mistake was introduced in table 1; FliJ should have read 'FlgJ' in the row of 'Lytic transglycosylase'. This has now been corrected in the PDF and online. The (Source: Nature Reviews Microbiology)
Source: Nature Reviews Microbiology - May 12, 2017 Category: Microbiology Authors: Wanyin Deng Natalie C. Marshall Jennifer L. Rowland James M. McCoy Liam J. Worrall Andrew S. Santos Natalie C. J. Strynadka B. Brett Finlay Tags: Corrigendum Source Type: research
Corrigendum: Metal homeostasis and resistance in bacteria
Nature Reviews Microbiology 15, 379 (2017).
doi:10.1038/nrmicro.2017.53
Author: Pete Chandrangsu, Christopher Rensing & John D. Helmann
Nature Reviews Microbiology15,
338–35010.1038/nrmicro.2017.15(2017)The acknowledgement section has been modified to include funding for Christopher Rensing. The following text has been added: C.R. is supported by the Strategic Priority Research Program of the Chinese Academy of Sciences (Source: Nature Reviews Microbiology)
Source: Nature Reviews Microbiology - May 12, 2017 Category: Microbiology Authors: Pete Chandrangsu Christopher Rensing John D. Helmann Tags: Corrigendum Source Type: research
A comprehensive guide to pilus biogenesis in Gram-negative bacteria
Nature Reviews Microbiology 15, 365 (2017).
doi:10.1038/nrmicro.2017.40
Authors: Manuela K. Hospenthal, Tiago R. D. Costa & Gabriel Waksman
Pili are crucial virulence factors for many Gram-negative pathogens. These surface structures provide bacteria with a link to their external environments by enabling them to interact with, and attach to, host cells, other surfaces or each other, or by providing a conduit for secretion. Recent (Source: Nature Reviews Microbiology)
Source: Nature Reviews Microbiology - May 12, 2017 Category: Microbiology Authors: Manuela K. Hospenthal Tiago R. D. Costa Gabriel Waksman Tags: Review Source Type: research
Reshaping the tree of life
Nature Reviews Microbiology 15, 322 (2017).
doi:10.1038/nrmicro.2017.51
Authors: Eva Heinz & Daryl Domman
This month's Genome Watch highlights how metagenomics is continuing to reveal the diversity of microorganisms in the environment and how it is challenging and expanding our understanding of how life evolved on Earth. (Source: Nature Reviews Microbiology)
Source: Nature Reviews Microbiology - May 12, 2017 Category: Microbiology Authors: Eva Heinz Daryl Domman Tags: News and Analysis Source Type: research
Biofilms: New ways for streptococci to settle down
Nature Reviews Microbiology 15, 321 (2017).
doi:10.1038/nrmicro.2017.57
Author: Irene Vacca
The respiratory tract of patients with cystic fibrosis is a polymicrobial environment in which Pseudomonas aeruginosa is a dominant pathogen and oral commensal streptococci are emerging as cohabitants. Using a dual species biofilm model, Scoffield et al. showed that Streptococcus parasanguinis uses (Source: Nature Reviews Microbiology)
Source: Nature Reviews Microbiology - May 12, 2017 Category: Microbiology Authors: Irene Vacca Tags: Research Highlight Source Type: research
Microbiota: Clostridia protect from gut infections in early life
Nature Reviews Microbiology 15, 321 (2017).
doi:10.1038/nrmicro.2017.56
Author: Irene Vacca
Neonates are highly susceptible to intestinal infections; this has been generally ascribed to the immaturity of the immune system, but other factors might contribute. Kim, Sakamoto et al. show that the composition of the gut microbiota is a key factor, as the microbiota protects (Source: Nature Reviews Microbiology)
Source: Nature Reviews Microbiology - May 12, 2017 Category: Microbiology Authors: Irene Vacca Tags: Research Highlight Source Type: research
