Distinct neural mechanisms for the control of thirst and salt appetite in the subfornical organ
Nature Neuroscience 20, 230 (2017).
doi:10.1038/nn.4463
Authors: Takashi Matsuda, Takeshi Y Hiyama, Fumio Niimura, Taiji Matsusaka, Akiyoshi Fukamizu, Kenta Kobayashi, Kazuto Kobayashi & Masaharu Noda (Source: Nature Neuroscience)
Source: Nature Neuroscience - December 18, 2016 Category: Neuroscience Authors: Takashi Matsuda Takeshi Y Hiyama Fumio Niimura Taiji Matsusaka Akiyoshi Fukamizu Kenta Kobayashi Kazuto Kobayashi Masaharu Noda Tags: Article Source Type: research
An independent, landmark-dominated head-direction signal in dysgranular retrosplenial cortex
Nature Neuroscience 20, 173 (2017).
doi:10.1038/nn.4465
Authors: Pierre-Yves Jacob, Giulio Casali, Laure Spieser, Hector Page, Dorothy Overington & Kate Jeffery
We investigated how landmarks influence the brain's computation of head direction and found that in a bidirectionally symmetrical environment, some neurons in dysgranular retrosplenial cortex showed bidirectional firing patterns. This indicates dominance of neural activity by local environmental cues even when these conflicted with the global head direction signal. It suggests a mechanism for associating landmarks to or dissociating them from the head d...
Source: Nature Neuroscience - December 18, 2016 Category: Neuroscience Authors: Pierre-Yves Jacob Giulio Casali Laure Spieser Hector Page Dorothy Overington Kate Jeffery Tags: Brief Communication Source Type: research
Subiculum neurons map the current axis of travel
Nature Neuroscience 20, 170 (2017).
doi:10.1038/nn.4464
Authors: Jacob M Olson, Kanyanat Tongprasearth & Douglas A Nitz
Flexible navigation demands knowledge of boundaries, routes and their relationships. Within a multi-path environment, a subpopulation of subiculum neurons robustly encoded the axis of travel. The firing of axis-tuned neurons peaked bimodally, at head orientations 180° apart. Environmental manipulations showed these neurons to be anchored to environmental boundaries but to lack axis tuning in an open arena. Axis-tuned neurons thus provide a powerful mechanism for mapping relationships betw...
Source: Nature Neuroscience - December 18, 2016 Category: Neuroscience Authors: Jacob M Olson Kanyanat Tongprasearth Douglas A Nitz Tags: Brief Communication Source Type: research
Manipulating stored phonological input during verbal working memory
Nature Neuroscience 20, 279 (2017).
doi:10.1038/nn.4459
Authors: Gregory B Cogan, Asha Iyer, Lucia Melloni, Thomas Thesen, Daniel Friedman, Werner Doyle, Orrin Devinsky & Bijan Pesaran (Source: Nature Neuroscience)
Source: Nature Neuroscience - December 11, 2016 Category: Neuroscience Authors: Gregory B Cogan Asha Iyer Lucia Melloni Thomas Thesen Daniel Friedman Werner Doyle Orrin Devinsky Bijan Pesaran Tags: Article Source Type: research
A cortical –hippocampal–cortical loop of information processing during memory consolidation
Nature Neuroscience 20, 251 (2017).
doi:10.1038/nn.4457
Authors: Gideon Rothschild, Elad Eban & Loren M Frank (Source: Nature Neuroscience)
Source: Nature Neuroscience - December 11, 2016 Category: Neuroscience Authors: Gideon Rothschild Elad Eban Loren M Frank Tags: Article Source Type: research
HSD2 neurons in the hindbrain drive sodium appetite
Nature Neuroscience 20, 167 (2017).
doi:10.1038/nn.4451
Authors: Brooke C Jarvie & Richard D Palmiter
Sodium-depleted animals develop an appetite for aversive concentrations of sodium. Here we show that chemogenetic activation of aldosterone-sensitive neurons that express 11β-hydroxysteroid dehydrogenase type 2 (HSD2) in the nucleus of the solitary tract is sufficient to drive consumption of sodium-containing solutions in mice, independently of thirst or hunger. These HSD2-positive neurons are necessary for full expression of sodium appetite and have distinct downstream targets that are activated during so...
Source: Nature Neuroscience - December 4, 2016 Category: Neuroscience Authors: Brooke C Jarvie Richard D Palmiter Tags: Brief Communication Source Type: research
Shared memories reveal shared structure in neural activity across individuals
Nature Neuroscience 20, 115 (2017).
doi:10.1038/nn.4450
Authors: Janice Chen, Yuan Chang Leong, Christopher J Honey, Chung H Yong, Kenneth A Norman & Uri Hasson (Source: Nature Neuroscience)
Source: Nature Neuroscience - December 4, 2016 Category: Neuroscience Authors: Janice Chen Yuan Chang Leong Christopher J Honey Chung H Yong Kenneth A Norman Uri Hasson Tags: Article Source Type: research
A probabilistic approach to demixing odors
Nature Neuroscience 20, 98 (2017).
doi:10.1038/nn.4444
Authors: Agnieszka Grabska-Barwińska, Simon Barthelmé, Jeff Beck, Zachary F Mainen, Alexandre Pouget & Peter E Latham (Source: Nature Neuroscience)
Source: Nature Neuroscience - December 4, 2016 Category: Neuroscience Authors: Agnieszka Grabska-Barwi ńska Simon Barthelm é Jeff Beck Zachary F Mainen Alexandre Pouget Peter E Latham Tags: Article Source Type: research
Developmentally defined forebrain circuits regulate appetitive and aversive olfactory learning
Nature Neuroscience 20, 20 (2017).
doi:10.1038/nn.4452
Authors: Nagendran Muthusamy, Xuying Zhang, Caroline A Johnson, Prem N Yadav & H Troy Ghashghaei
Postnatal and adult neurogenesis are region- and modality-specific, but the significance of developmentally distinct neuronal populations remains unclear. We demonstrate that chemogenetic inactivation of a subset of forebrain and olfactory neurons generated at birth disrupts responses to an aversive odor. In contrast, novel appetitive odor learning is sensitive to inactivation of adult-born neurons, revealing that developmentally defined sets of neurons may diff...
Source: Nature Neuroscience - December 4, 2016 Category: Neuroscience Authors: Nagendran Muthusamy Xuying Zhang Caroline A Johnson Prem N Yadav H Troy Ghashghaei Tags: Brief Communication Source Type: research
Viewpoints: Dialogues on the functional role of the ventromedial prefrontal cortex
Nature Neuroscience 19, 1545 (2016).
doi:10.1038/nn.4438
Authors: Mauricio R Delgado, Jennifer S Beer, Lesley K Fellows, Scott A Huettel, Michael L Platt, Gregory J Quirk & Daniela Schiller
The ventromedial prefrontal cortex is attributed with various functions during valuation, affect regulation and social cognition. Nature Neuroscience asked a moderator to lead researchers in a dialogue on shared and distinct viewpoints of this region's roles. (Source: Nature Neuroscience)
Source: Nature Neuroscience - November 28, 2016 Category: Neuroscience Authors: Mauricio R Delgado Jennifer S Beer Lesley K Fellows Scott A Huettel Michael L Platt Gregory J Quirk Daniela Schiller Tags: Q & A Source Type: research
The slippery slope of dishonesty
Nature Neuroscience 19, 1543 (2016).
doi:10.1038/nn.4441
Authors: Jan B Engelmann & Ernst Fehr
Recent experiments suggest that dishonesty can escalate from small levels to ever-larger ones along a 'slippery slope'. Activity in bilateral amygdala tracks this gradual adaptation to repeated acts of self-serving dishonesty. (Source: Nature Neuroscience)
Source: Nature Neuroscience - November 28, 2016 Category: Neuroscience Authors: Jan B Engelmann Ernst Fehr Tags: News and Views Source Type: research
Many paths from state to state
Nature Neuroscience 19, 1541 (2016).
doi:10.1038/nn.4440
Authors: Matthew T Kaufman & Anne K Churchland
Humans and animals can collect and maintain information that guides decisions, but how neural circuits achieve this is unknown. It seems neural populations may do so by passing through diverse states in many possible sequences. (Source: Nature Neuroscience)
Source: Nature Neuroscience - November 28, 2016 Category: Neuroscience Authors: Matthew T Kaufman Anne K Churchland Tags: News and Views Source Type: research
Astrocyte endfeet march to the beat of different vessels
Nature Neuroscience 19, 1539 (2016).
doi:10.1038/nn.4446
Authors: Ravi L Rungta & Serge Charpak
During synaptic activation, the function of astrocyte endfeet depends on the vascular target: at the capillary, but not at the arteriole, a newly described P2X1R–phospholipase D2 pathway modulates prostaglandin E2 release and vessel dilation. (Source: Nature Neuroscience)
Source: Nature Neuroscience - November 28, 2016 Category: Neuroscience Authors: Ravi L Rungta Serge Charpak Tags: News and Views Source Type: research
Rare mutations and educational attainment
Nature Neuroscience 19, 1538 (2016).
doi:10.1038/nn.4445
Author: David Cesarini
Intellectual disabilities and associated neurodevelopmental disorders may result from rare genetic mutations. Ganna et al. show that these also help explain variability in educational attainment, a proxy for cognitive function. (Source: Nature Neuroscience)
Source: Nature Neuroscience - November 28, 2016 Category: Neuroscience Authors: David Cesarini Tags: News and Views Source Type: research
Viewpoints: an interactive forum for debates and discussions
Nature Neuroscience 19, 1537 (2016).
doi:10.1038/nn.4453
Neuroscientists dedicate themselves to understanding the brain. But what happens when they disagree on experimental outcomes, data interpretation or methodology? Nature Neuroscience debuts a format that invites researchers to debate critical issues in neuroscience. (Source: Nature Neuroscience)
Source: Nature Neuroscience - November 28, 2016 Category: Neuroscience Tags: Editorial Source Type: research
