Developmentally defined forebrain circuits regulate appetitive and aversive olfactory learning

Nature Neuroscience 20, 20 (2017). doi:10.1038/nn.4452 Authors: Nagendran Muthusamy, Xuying Zhang, Caroline A Johnson, Prem N Yadav & H Troy Ghashghaei Postnatal and adult neurogenesis are region- and modality-specific, but the significance of developmentally distinct neuronal populations remains unclear. We demonstrate that chemogenetic inactivation of a subset of forebrain and olfactory neurons generated at birth disrupts responses to an aversive odor. In contrast, novel appetitive odor learning is sensitive to inactivation of adult-born neurons, revealing that developmentally defined sets of neurons may differentially participate in hedonic aspects of sensory learning.
Source: Nature Neuroscience - Category: Neuroscience Authors: Tags: Brief Communication Source Type: research