Developmentally defined forebrain circuits regulate appetitive and aversive olfactory learning
Nature Neuroscience 20, 20 (2017).
doi:10.1038/nn.4452
Authors: Nagendran Muthusamy, Xuying Zhang, Caroline A Johnson, Prem N Yadav & H Troy Ghashghaei
Postnatal and adult neurogenesis are region- and modality-specific, but the significance of developmentally distinct neuronal populations remains unclear. We demonstrate that chemogenetic inactivation of a subset of forebrain and olfactory neurons generated at birth disrupts responses to an aversive odor. In contrast, novel appetitive odor learning is sensitive to inactivation of adult-born neurons, revealing that developmentally defined sets of neurons may differentially participate in hedonic aspects of sensory learning.
Source: Nature Neuroscience - Category: Neuroscience Authors: Nagendran Muthusamy Xuying Zhang Caroline A Johnson Prem N Yadav H Troy Ghashghaei Tags: Brief Communication Source Type: research