Associations of myeloid hematological diseases of the elderly with Osteoporosis: A longitudinal analysis of routine health care data
(Source: Leukemia Research)
Source: Leukemia Research - April 20, 2018 Category: Hematology Authors: Thomas Datzmann, Freya Trautmann, Falko Tesch, Anna Mies, Lorenz C. Hofbauer, Uwe Platzbecker, Jochen Schmitt Tags: Research paper Source Type: research
Cell membrane-bound CD200 signals both via an extracellular domain and following nuclear translocation of a cytoplasmic fragment
CD200 engagement of its cognate receptor, CD200R, has been shown to cause attenuation of both inflammatory responses and the development of acquired immune responses, as determined by, amongst others, a suppression of T cell mediated transplant rejection response and inflammatory cytokine production in models of autoimmune arthritis [1]. While in mice a number of different CD200Rs have been described, in humans it seems only one, conventionally referred to as CD200R1, is transcribed and biologically functional [1]. (Source: Leukemia Research)
Source: Leukemia Research - April 18, 2018 Category: Hematology Authors: Zhiqi Chen, Andras Kapus, Ismat Khatri, Olha Kos, Fang Zhu, Reginald M. Gorczynski Tags: Research paper Source Type: research
Cell membrane-bound CD200 signals both via an extracellular domain and following nuclear translocation of a cytoplasmic fragment
(Source: Leukemia Research)
Source: Leukemia Research - April 18, 2018 Category: Hematology Authors: Zhiqi Chen, Andras Kapus, Ismat Khatri, Olha Kos, Fang Zhu, Reginald M. Gorczynski Tags: Research paper Source Type: research
Corrigendum to ’CD41 immune staining of micromegakaryocytes improves the diagnosis of myelodysplastic syndrome and differentiation from pancytopenia’ [leukemia research. 2018; 66: 15-19]
The authors regret that Lifang Huang and Miao Zheng contributed equally to this work and should be considered as co-first authors. (Source: Leukemia Research)
Source: Leukemia Research - April 17, 2018 Category: Hematology Authors: Jinjin Huang, Zhiqiong Wang, Lifang Huang, Miao Zheng Source Type: research
Editorial Board
(Source: Leukemia Research)
Source: Leukemia Research - April 17, 2018 Category: Hematology Source Type: research
The Rising Prevalence of Chronic Myeloid Leukemia in France
(Source: Leukemia Research)
Source: Leukemia Research - April 17, 2018 Category: Hematology Authors: Marc Delord, St éphanie Foulon, Jean-Michel Cayuela, Philippe Rousselot, Julia Bonastre Tags: Research paper Source Type: research
Effect of absolute monocyte count post-transplant on the outcome of patients with acute myeloid leukemia undergoing myeloablative allogeneic hematopoietic stem cell transplant with busulfan and cyclophosphamide conditioning
Acute myeloid leukemia (AML) is a heterogeneous group of malignant hematological neoplasms characterized by uncontrolled rapid proliferation of myeloblasts. It is an aggressive leukemia that can be rapidly fatal without treatment [1,2]. Despite improvements in chemotherapy and supportive care, as well as the availability of hematopoietic stem cell transplantation (HSCT) and the development of molecular target therapies during the last two decades, the long-term survival of patients with AML remains poor, as the majority of cases relapse or are refractory to treatment [3,4]. (Source: Leukemia Research)
Source: Leukemia Research - April 11, 2018 Category: Hematology Authors: Liyuan Tang, Na Wang, Chongyun Xing, Qiang Zhuang, Bin Liang, Lan Sun, Yi Chen, Yan Qian, Zhijian Shen, Songfu Jiang, Kang Yu, Jianhua Feng Tags: Research paper Source Type: research
Effect of absolute monocyte count post-transplant on the outcome of patients with acute myeloid leukemia undergoing myeloablative allogeneic hematopoietic stem cell transplant with busulfan and cyclophosphamide conditioning
(Source: Leukemia Research)
Source: Leukemia Research - April 11, 2018 Category: Hematology Authors: Liyuan Tang, Na Wang, Chongyun Xing, Qiang Zhuang, Bin Liang, Lan Sun, Yi Chen, Yan Qian, Zhijian Shen, Songfu Jiang, Kang Yu, Jianhua Feng Tags: Research paper Source Type: research
Inter-observer variance and the need for standardization in the morphological classification of myelodysplastic syndrome
Myelodysplastic syndrome (MDS) is a hematopoietic malignancy characterized by morphological atypia (dysplasia) of hematopoietic cells, ineffective hematopoiesis, peripheral cytopenia and progression to acute myeloid leukemia (AML). The disease is often found in the elderly: The median age of disease diagnosis is 76 years, with around 30 out of a 100,000 people aged 70 years or older diagnosed with MDS each year, whereas the frequency is 3 –4 among people less than 70 years of age [1]. Recently, it was found that the disease becomes obvious when hematopoietic stem cells sequentially acquire several to ten somatic and/or g...
Source: Leukemia Research - April 9, 2018 Category: Hematology Authors: Keiko Sasada, Noriko Yamamoto, Hiroki Masuda, Yoko Tanaka, Ayako Ishihara, Yasushi Takamatsu, Yutaka Yatomi, Waichiro Katsuda, Issei Sato, Hirotaka Matsui, on behalf of the Kyushu regional department of the Japanese Society of Laboratory Hematology Tags: Research paper Source Type: research
Inter-observer variance and the need for standardization in the morphological classification of myelodysplastic syndrome
(Source: Leukemia Research)
Source: Leukemia Research - April 9, 2018 Category: Hematology Authors: Keiko Sasada, Noriko Yamamoto, Hiroki Masuda, Yoko Tanaka, Ayako Ishihara, Yasushi Takamatsu, Yutaka Yatomi, Waichiro Katsuda, Issei Sato, Hirotaka Matsui, on behalf of the Kyushu regional department of the Japanese Society of Laboratory Hematology Tags: Research paper Source Type: research
Inhibition of NAMPT sensitizes MOLT4 leukemia cells for etoposide treatment through the SIRT2-p53 pathway
Leukemia is the most common cancer diagnosed in children and represents approximately 30% of cancer diagnoses among children younger than 15 years [1]. The main treatment for childhood leukemia is chemotherapy [2]. Children with high-risk leukemia or relapse generally receive more intense and aggressive chemotherapy, e.g. treatment with etoposide [3,4]. Although chemotherapy is successful in up to 90% of pediatric patients with acute lymphoblastic leukemia, the toxicity of chemotherapy is a common cause of morbidity and mortality in children during treatment and later in life [5]. (Source: Leukemia Research)
Source: Leukemia Research - April 5, 2018 Category: Hematology Authors: Theresa Grohmann, Melanie Penke, Stefanie Petzold-Quinque, Susanne Schuster, Sandy Richter, Wieland Kiess, Antje Garten Source Type: research
Inhibition of NAMPT sensitizes MOLT4 leukemia cells for etoposide treatment through the SIRT2-p53 pathway
(Source: Leukemia Research)
Source: Leukemia Research - April 5, 2018 Category: Hematology Authors: Theresa Grohmann, Melanie Penke, Stefanie Petzold-Quinque, Susanne Schuster, Sandy Richter, Wieland Kiess, Antje Garten Source Type: research
New rapid method to detect BCR-ABL fusion genes with multiplex RT-qPCR in one-tube at a time
Identification of specific recurrent genetic abnormalities is critical for disease evaluation, optimal risk stratification, and treatment planning, which is recommended by the USA National Comprehensive Cancer Network [1]. The Philadelphia chromosome (Ph) is a chromosome 22 derivative resulting from a translocation between chromosomes 9 and 22 causing the BCR-ABL fusion [2]. BCR-ABL fusions are present in approximately 95% of chronic myelogenous leukemia (CML), and 25 –30% of adult acute lymphoblastic leukemia (ALL) cases [3]. (Source: Leukemia Research)
Source: Leukemia Research - April 4, 2018 Category: Hematology Authors: Yong-Qing Tong, Zhi-Jun Zhao, Bei Liu, An-Yu Bao, Hong-Yun Zheng, Jian Gu, Ying Xia, Mary McGrath, Sinisa Dovat, Chun-Hua Song, Yan Li Tags: Research paper Source Type: research
New rapid method to detect BCR-ABL fusion genes with multiplex RT-qPCR in one-tube at a time
(Source: Leukemia Research)
Source: Leukemia Research - April 4, 2018 Category: Hematology Authors: Yong-Qing Tong, Zhi-Jun Zhao, Bei Liu, An-Yu Bao, Hong-Yun Zheng, Jian Gu, Ying Xia, Mary McGrath, Sinisa Dovat, Chunhua Song, Yan Li Tags: Research paper Source Type: research
