New rapid method to detect BCR-ABL fusion genes with multiplex RT-qPCR in one-tube at a time

Identification of specific recurrent genetic abnormalities is critical for disease evaluation, optimal risk stratification, and treatment planning, which is recommended by the USA National Comprehensive Cancer Network [1]. The Philadelphia chromosome (Ph) is a chromosome 22 derivative resulting from a translocation between chromosomes 9 and 22 causing the BCR-ABL fusion [2]. BCR-ABL fusions are present in approximately 95% of chronic myelogenous leukemia (CML), and 25 –30% of adult acute lymphoblastic leukemia (ALL) cases [3].

Source: Leukemia Research - April 4, 2018 Category: Hematology Authors: Yong-Qing Tong, Zhi-Jun Zhao, Bei Liu, An-Yu Bao, Hong-Yun Zheng, Jian Gu, Ying Xia, Mary McGrath, Sinisa Dovat, Chun-Hua Song, Yan Li Tags: Research paper Source Type: research