Journal of Tissue Engineering and Regenerative Medicine 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Collagen nanofibre anisotropy induces myotube differentiation and acetylcholine receptor clustering
Abstract
To create musculoskeletal tissue scaffolds for functional integration into host tissue, myotubes must be properly aligned with native tissue and spur the formation of neuromuscular junctions. However, our understanding of myoblast differentiation in response to structural alignment is incomplete. To examine how substrate anisotropy mediates myotube differentiation, we studied C2C12 myoblasts grown on aligned collagen substrates in the presence or absence of agrin. Myoblasts grown on microfluidically patterned collagen substrates demonstrated increased multinucleated myotubes and nicotinic acetylcholine receptor (A...
Source: Journal of Tissue Engineering and Regenerative Medicine - January 8, 2018 Category: Biotechnology Authors: Frank H. Kung, David Sillitti, Anil B. Shrirao, David I. Shreiber, Bonnie L. Firestein Tags: RESEARCH ARTICLE Source Type: research
Mimicking corneal stroma using keratocyte ‐loaded photopolymerizable methacrylated gelatin hydrogels
Journal of Tissue Engineering and Regenerative Medicine, EarlyView. (Source: Journal of Tissue Engineering and Regenerative Medicine)
Source: Journal of Tissue Engineering and Regenerative Medicine - January 3, 2018 Category: Biotechnology Source Type: research
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Journal of Tissue Engineering and Regenerative Medicine, Ahead of Print. (Source: Journal of Tissue Engineering and Regenerative Medicine)
Source: Journal of Tissue Engineering and Regenerative Medicine - January 3, 2018 Category: Biotechnology Source Type: research
Mimicking corneal stroma using keratocyte ‐loaded photopolymerizable methacrylated gelatin hydrogels
Abstract
Cell‐laden methacrylated gelatin (GelMA) hydrogels with high (approximately 90%) transparency were prepared to mimic the natural form and function of corneal stroma. They were synthesized from GelMA with a methacrylation degree of 70% as determined by nuclear magnetic resonance. Hydrogels were strong enough to withstand handling. Stability studies showed that 87% of the GelMA hydrogels remained after 21 days in phosphate buffered saline (PBS). Cell viability in the first 2 days was over 90% for the human keratocytes loaded in the gels as determined with the live–dead analysis. Cells in the hydrogel elongated...
Source: Journal of Tissue Engineering and Regenerative Medicine - January 3, 2018 Category: Biotechnology Authors: Cemile Kilic Bektas, Vasif Hasirci Tags: RESEARCH ARTICLE Source Type: research
Semaphorin 3A receptor inhibitor as a novel therapeutic to promote innervation of bioengineered teeth
In conclusion, these data show that inhibition of only one axon repellent molecule, Sema3A, allows for pulp innervation of bioengineered teeth. (Source: Journal of Tissue Engineering and Regenerative Medicine)
Source: Journal of Tissue Engineering and Regenerative Medicine - January 1, 2018 Category: Biotechnology Authors: Sabine Kuchler ‐Bopp, Dominique Bagnard, Michael Van‐der‐Heyden, Ysia Idoux‐Gillet, Marion Strub, Hervé Gegout, Hervé Lesot, Nadia Benkirane‐Jessel, Laetitia Keller Tags: RESEARCH ARTICLE Source Type: research
Novel Standardized Massive Bone Defect Model in Rats Employing an Internal Eight ‐Hole Stainless Steel Plate For Bone Tissue Engineering
Abstract
Massive bone defects are a challenge in orthopedic research. Defective regeneration leads to bone atrophy, non‐union of bone and physical morbidity. Large animals are important models, however, production costs are high, nursing is complex and evaluation methods are limited. A suitable laboratory animal model is required to explore the underlying molecular mechanism and cellular process of bone tissue engineering. We designed a stainless steel plate with eight holes; the middle two holes were used as a guide to create a standardized critical size defect in the femur of anesthetized rats. The plate was fixed to t...
Source: Journal of Tissue Engineering and Regenerative Medicine - January 1, 2018 Category: Biotechnology Authors: Huijie Jianga, Pengzhen Chenga, Donglin Lia, Junqin Lia, Jimeng Wanga, Yi Gaoa, Shuaishuai Zhanga, Tianqing Caoa, Chunmei Wanga, Liu Yanga, Guoxian Peia Tags: RESEARCH ARTICLE Source Type: research
Therapeutic effects of a recombinant human collagen peptide bioscaffold with human adipose ‐derived stem cells on impaired wound healing after radiotherapy
In this study, novel recombinant human collagen peptide (rhCP) scaffolds were evaluated as a biomaterial carrier for cellular regenerative therapy. Human adipose‐derived stem cells (hASCs) were successfully cultured on rhCP scaffolds. By hASC culture on rhCP, microarray assay indicated that expression of genes related to cell proliferation and extracellular matrix production was upregulated. Pathway analyses revealed that signaling pathways related to inflammatory suppression and cell growth promotion were activated as well as signaling pathways consistent with some growth factors including vascular endothelial growth fa...
Source: Journal of Tissue Engineering and Regenerative Medicine - January 1, 2018 Category: Biotechnology Authors: Takanobu Mashiko, Hitomi Takada, Szu ‐Hsien Wu, Koji Kanayama, Jingwei Feng, Kensuke Tashiro, Rintaro Asahi, Ataru Sunaga, Kazuto Hoshi, Akira Kurisaki, Tsuyoshi Takato, Kotaro Yoshimura Tags: RESEARCH ARTICLE Source Type: research
Development of a transendothelial shuttle by macrophage modification
Journal of Tissue Engineering and Regenerative Medicine, EarlyView. (Source: Journal of Tissue Engineering and Regenerative Medicine)
Source: Journal of Tissue Engineering and Regenerative Medicine - December 28, 2017 Category: Biotechnology Source Type: research
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Journal of Tissue Engineering and Regenerative Medicine, Ahead of Print. (Source: Journal of Tissue Engineering and Regenerative Medicine)
Source: Journal of Tissue Engineering and Regenerative Medicine - December 28, 2017 Category: Biotechnology Source Type: research
Electrospun titania fiber mats spin coated with thin polymer films as nanofibrous scaffolds for enhanced cell proliferation
Journal of Tissue Engineering and Regenerative Medicine, EarlyView. (Source: Journal of Tissue Engineering and Regenerative Medicine)
Source: Journal of Tissue Engineering and Regenerative Medicine - December 27, 2017 Category: Biotechnology Source Type: research
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Journal of Tissue Engineering and Regenerative Medicine, Ahead of Print. (Source: Journal of Tissue Engineering and Regenerative Medicine)
Source: Journal of Tissue Engineering and Regenerative Medicine - December 27, 2017 Category: Biotechnology Source Type: research
Electrospun titania fiber mats spin coated with thin polymer films as nanofibrous scaffolds for enhanced cell proliferation
In this study, polymer‐inorganic composite fibres consisting of poly(2‐ethyl‐2‐oxazoline) (PEOXA) and tetrabutyl titanate as the titanium precursor were successfully fabricated through a combined sol–gel/electrospinning approach. PEOXA/Ti(OR)n composite fibres were obtained with varying amounts of polymer and titanium precursors. Calcinations of the composite fibres were performed at varying temperatures to produce TiO2 fibres (TiO2‐T‐60) with anatase, anatase/rutile mixed phase, and rutile crystal structures. Thin polymer films (i.e., poly(2‐ethyl‐2‐oxazoline) (PEOXA), polycaprolactone (PCL), and poly(...
Source: Journal of Tissue Engineering and Regenerative Medicine - December 27, 2017 Category: Biotechnology Authors: Alfin Kurniawan, Chintya Effendi, Meng ‐Jiy Wang Tags: RESEARCH ARTICLE Source Type: research
A phase I/II exploratory clinical trial for intracordal injection of recombinant hepatocyte growth factor for vocal fold scar and sulcus
Journal of Tissue Engineering and Regenerative Medicine, EarlyView. (Source: Journal of Tissue Engineering and Regenerative Medicine)
Source: Journal of Tissue Engineering and Regenerative Medicine - December 25, 2017 Category: Biotechnology Source Type: research
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Journal of Tissue Engineering and Regenerative Medicine, Ahead of Print. (Source: Journal of Tissue Engineering and Regenerative Medicine)
Source: Journal of Tissue Engineering and Regenerative Medicine - December 25, 2017 Category: Biotechnology Source Type: research
Segregation of motor and sensory axons regenerating through bicompartmental tubes by combining extracellular matrix components with neurotrophic factors
Abstract
Segregation of regenerating motor and sensory axons may be a good strategy to improve selective functionality of regenerative interfaces to provide close loop commands. Provided that extracellular matrix (ECM) components and neurotrophic factors (NTFs) exert guidance effects on different neuronal populations, we assessed in vivo the potential of separating sensory and motor axons regenerating in a bicompartmental Y‐type tube, with each branch prefilled with an adequate combination of ECM and NTFs.
The severed rat sciatic nerve was repaired using a bicompartmental tube filled with a collagen matrix enriched with ...
Source: Journal of Tissue Engineering and Regenerative Medicine - December 21, 2017 Category: Biotechnology Authors: Jaume Valle, Daniel Santos, Ignacio Delgado ‐Martínez, Natàlia Oliva, Guido Giudetti, Silvestro Micera, Xavier Navarro Tags: RESEARCH ARTICLE Source Type: research
