Zyflamend in men with high-grade prostatic intraepithelial neoplasia: results of a phase I clinical trial.
Authors: Capodice JL, Gorroochurn P, Cammack AS, Eric G, McKiernan JM, Benson MC, Stone BA, Katz AE Abstract Subjects diagnosed with high-grade prostatic intraepithelial neoplasia (HGPIN) at biopsy are at increased risk for developing prostate cancer (CaP). A prospective clinical trial was done to determine the safety and tolerability of a novel herbal amalgam, Zyflamend (New Chapter, Inc., Brattleboro, VT), with various dietary supplements in subjects with HGPIN. Men ages 40 to 75 years with HGPIN were eligible. Subjects were evaluated for 18 months. Every 3 months, standard blood chemistries and prostate...
Source: Journal of the Society for Integrative Oncology - December 2, 2014 Category: Cancer & Oncology Tags: J Soc Integr Oncol Source Type: research

Acupuncture for nonpalliative radiation therapy-related fatigue: feasibility study.
Authors: Mao JJ, Styles T, Cheville A, Wolf J, Fernandes S, Farrar JT Abstract The purpose of this study was to determine the feasibility of an acupuncture clinical trial to prevent radiation therapy (RT)-induced fatigue. We conducted a cross-sectional survey study and a single-arm acupuncture clinical trial among patients undergoing RT. Patients with a Karnofsky score of less than 60, severe anemia, or substantial psychological diagnoses were excluded. Patients received up to 12 treatments of acupuncture over the entire course of their RT. The Lee Fatigue Scale (LFS) was administered at baseline, in the m...
Source: Journal of the Society for Integrative Oncology - December 2, 2014 Category: Cancer & Oncology Tags: J Soc Integr Oncol Source Type: research

beta-carboline alkaloid-enriched extract from the amazonian rain forest tree pao pereira suppresses prostate cancer cells.
Authors: Bemis DL, Capodice JL, Desai M, Katz AE, Buttyan R Abstract Bark extracts from the Amazonian rain forest tree Geissospermum vellosii (pao pereira), enriched in alpha-carboline alkaloids have significant anticancer activities in certain preclinical models. Because of the predominance of prostate cancer as a cause of cancer-related morbidity and mortality for men of Western countries, we preclinically tested the in vitro and in vivo effects of a pao pereira extract against a prototypical human prostate cancer cell line, LNCaP. When added to cultured LNCaP cells, pao pereira extract significantly sup...
Source: Journal of the Society for Integrative Oncology - December 2, 2014 Category: Cancer & Oncology Tags: J Soc Integr Oncol Source Type: research

Maitake mushroom (Grifola frondosa): systematic review by the natural standard research collaboration.
The objective of this study was to evaluate the scientific evidence on maitake, including expert opinion, folkloric precedent, history, pharmacology, kinetics/dynamics, interactions, adverse effects, toxicology, and dosing. This review serves as a clinical support tool. Electronic searches were conducted in 10 databases, 20 additional journals (not indexed in common databases), and bibliographies from 50 selected secondary references. No restrictions were placed on the language or quality of the publications. All literature collected pertained to efficacy in humans, dosing, precautions, adverse effects, use in pregnancy an...
Source: Journal of the Society for Integrative Oncology - December 2, 2014 Category: Cancer & Oncology Tags: J Soc Integr Oncol Source Type: research

Essiac: systematic review by the natural standard research collaboration.
The objective of this study was to evaluate the scientific evidence on the safety and efficacy of Essiac. This review serves as a clinical support tool. Electronic searches were conducted in 10 databases, 20 additional journals (not indexed in common databases), and bibliographies from 50 selected secondary references. No restrictions were placed on the language or quality of the publications. Standardized inclusion and exclusion criteria were used for selection. A review of the literature on Essiac and essiac formulations showed a lack of high-quality clinical trials to substantiate any of Essiac's traditional uses. Weak ...
Source: Journal of the Society for Integrative Oncology - December 2, 2014 Category: Cancer & Oncology Tags: J Soc Integr Oncol Source Type: research

Maitake.
Authors: PMID: 19476743 [PubMed - indexed for MEDLINE] (Source: Journal of the Society for Integrative Oncology)
Source: Journal of the Society for Integrative Oncology - December 2, 2014 Category: Cancer & Oncology Tags: J Soc Integr Oncol Source Type: research

Evidence-based clinical practice guidelines for integrative oncology: complementary therapies and botanicals (2009).
Authors: Sagar SM PMID: 19706234 [PubMed - indexed for MEDLINE] (Source: Journal of the Society for Integrative Oncology)
Source: Journal of the Society for Integrative Oncology - December 2, 2014 Category: Cancer & Oncology Tags: J Soc Integr Oncol Source Type: research

Evidence-based clinical practice guidelines for integrative oncology: complementary therapies and botanicals.
Authors: Deng GE, Frenkel M, Cohen L, Cassileth BR, Abrams DI, Capodice JL, Courneya KS, Dryden T, Hanser S, Kumar N, Labriola D, Wardell DW, Sagar S, Society for Integrative Oncology PMID: 19706235 [PubMed - indexed for MEDLINE] (Source: Journal of the Society for Integrative Oncology)
Source: Journal of the Society for Integrative Oncology - December 2, 2014 Category: Cancer & Oncology Tags: J Soc Integr Oncol Source Type: research

Dong Quai (Angelica sinensis).
Authors: PMID: 19706236 [PubMed - indexed for MEDLINE] (Source: Journal of the Society for Integrative Oncology)
Source: Journal of the Society for Integrative Oncology - December 2, 2014 Category: Cancer & Oncology Tags: J Soc Integr Oncol Source Type: research

CVT-E002 stimulates the immune system and extends the life span of mice bearing a tumor of viral origin.
This study represents the first in vivo demonstration of the anticancer efficacy of CVT-E002 in an animal model. CVT-E002 treatment significantly elevated the absolute numbers of natural killer cells and monocytes and reduced the number of tumor cells in the bone marrow and spleen. This study has shown that (1) approximately 30 to 50% of tumor-bearing mice administered CVT-E002 at a dose of 40 mg/d achieved a significantly extended life span, and (2) dosage is critical in producing these ameliorative effects. PMID: 19883528 [PubMed - indexed for MEDLINE] (Source: Journal of the Society for Integrative Oncology)
Source: Journal of the Society for Integrative Oncology - December 2, 2014 Category: Cancer & Oncology Tags: J Soc Integr Oncol Source Type: research

Systematic evaluation of the clinical effects of supportive mistletoe treatment within chemo- and/or radiotherapy protocols and long-term mistletoe application in nonmetastatic colorectal carcinoma: multicenter, controlled, observational cohort study.
This study was designed to evaluate supportive treatment with mistletoe extract Iscador (ISC) in nonmetastatic CRC patients under routine clinical conditions and to create well-founded hypotheses for future prospective clinical studies. The design of a multicenter, controlled, retrospective, observational cohort study with parallel groups met the Good Epidemiological Practice rules. Anonymous unselected standardized data from eligible patients with surgically treated stage I-III CRC and adjuvant therapy (AT) or conventional aftercare were included. End points were adjuvant therapy-related adverse reactions (AT-ADRs), sympt...
Source: Journal of the Society for Integrative Oncology - December 2, 2014 Category: Cancer & Oncology Tags: J Soc Integr Oncol Source Type: research

Spirituality of childhood cancer survivors.
Authors: Morse EE, O'Rourke K Abstract With the survival rates for childhood cancer growing, studies point to both the challenges and possible opportunities for personal growth that children with cancer may experience throughout their life journey. Examined in this review, research on the spirituality of childhood cancer survivors has provided insight into their overall spiritual journeys, their strategies to promote well-being, and the dynamics of hope and meaning within their lives. In an area that is in the early stages of research, the qualitative and exploratory research of the spirituality of childho...
Source: Journal of the Society for Integrative Oncology - December 2, 2014 Category: Cancer & Oncology Tags: J Soc Integr Oncol Source Type: research

Cancer-induced cachexia: a guide for the oncologist.
Authors: Gullett N, Rossi P, Kucuk O, Johnstone PA Abstract Cancer-induced cachexia (CIC) is a paraneoplastic syndrome that may account for up to 20% of deaths in cancer patients. Cachexia includes distinct metabolic changes that are the result of an acute-phase response (APR) mounted by the host as a reaction to tumor cells. These changes include increased muscle proteolysis, increased fat lipolysis, and increased hepatic production of acute-phase proteins such as C-reactive protein and fibrinogen. This APR pathogenesis is an important consideration in trying to treat cachectic patients as most therapies ...
Source: Journal of the Society for Integrative Oncology - December 2, 2014 Category: Cancer & Oncology Tags: J Soc Integr Oncol Source Type: research

Kava (Piper methysticum).
Authors: PMID: 19883532 [PubMed - indexed for MEDLINE] (Source: Journal of the Society for Integrative Oncology)
Source: Journal of the Society for Integrative Oncology - December 2, 2014 Category: Cancer & Oncology Tags: J Soc Integr Oncol Source Type: research

Music for patients with hematological malignancies undergoing bone marrow biopsy: a randomized controlled study of anxiety, perceived pain, and patient satisfaction.
CONCLUSIONS: While there were no significant group differences for the music intervention compared to standard of care for anxiety or perceived pain, additional feedback indicated that patients found the music intervention beneficial and requested use of music during future procedures. PMID: 24619452 [PubMed - as supplied by publisher] (Source: Journal of the Society for Integrative Oncology)
Source: Journal of the Society for Integrative Oncology - December 2, 2014 Category: Cancer & Oncology Tags: J Soc Integr Oncol Source Type: research