Treatment of Advanced Glaucomas Using Leksell Gamma Knife (LGK)--A Pilot Clinical Study
AbstractThe use of radiosurgery in treatment of the glaucomas is a completely new way of treating advanced stages of this treacherous disease. Up to now, the most common indications for the LGK therapy in ophthalmology at our department are malignant melanoma, vascular diseases, intraocular and intraorbital metastasis, and glioma of the optic nerve. Our pilot study shows that focal irradiation of the ciliary body in advanced glaucoma can ameliorate the main symptoms and thus prevent the otherwise inevitable enucleation of the eye. We treated in 12 patients, 13 very painful eyes, who were blind or with very diminished visio...
Source: Journal of Radiosurgery - September 1, 2000 Category: Radiology Source Type: research
Brief Commentary Treating Brain Metastases from Hepatoma with Stereotactic Radiosurgery
(Source: Journal of Radiosurgery)
Source: Journal of Radiosurgery - September 1, 2000 Category: Radiology Source Type: research
Gamma Knife (GK) Radiosurgery for Pituitary Adenomas: Evaluation of a Series of 163 Patients
Abstract
We have analyzed a group of 163 patients with pituitary adenoma treated by the GK for 5 years. They were followed up for 12–60 months (median 24 months) after irradiation. An antiproliferative effect has been achieved using the minimal dose 16–35 Gy with median of 20 Gy to the tumor margin in all of our patients who were controlled by MRI (n = 126 patients). One-half of these adenomas noticeably decreased in size. This antiproliferative dose was safe for the surrounding structures. The effect was not dependent on the gender or age of the patient, on previous fractionated radiotherapy, or on...
Source: Journal of Radiosurgery - September 1, 2000 Category: Radiology Source Type: research
Stereotactic Radiosurgery for Brainstem and Thalamic Metastases
This study reviews one institution's experience with the use of stereotactic radiosurgery (SRS) for brainstem and thalamic metastases to evaluate its efficacy in treating such lesions. Between October 1989 and January 1998, 20 patients (9 men, 11 women) underwent linear accelerator SRS for metastases in the brainstem or thalamus. A retrospective chart and radiographic analysis was performed on these patients. The mean patient age at the time of SRS was 55.9 years (range 34–76). The median dose of SRS was 1600 cGy (range 1200–2000) to the 80% isodose line, although the isodose line varied somewhat. Of the 20 lesions, me...
Source: Journal of Radiosurgery - September 1, 2000 Category: Radiology Source Type: research
Permanent Iodine-125 Implants in the Treatment of Low-Grade Gliomas
We report a retrospective study on the use of the permanent iodine-125 (125I) implants in the management of low-grade gliomas. From July 1988 to July 1997, 16 patients with low-grade gliomas underwent permanent 125I implants in the management of their lesions. There were 7 males and 9 females ranging in age from 4 to 48 years (mean 19). The location was in the cerebral hemisphere in 7 patients, brainstem in 5 patients and thalamus/basal ganglia in 4 patients. Prior to brachytherapy, 9 patients underwent surgical resection and 7 patients underwent stereotactic biopsy procedures. Fourteen patients were treated as part of the...
Source: Journal of Radiosurgery - September 1, 2000 Category: Radiology Source Type: research
Two-Staged Radiosurgical Treatment of Large Arteriovenous Malformations
Abstract
When the size of an arteriovenous malformation (AVM) in any one direction is more than 4 cm, an attempt is made to treat it in two stages, separated by 6 months. The first stage treats one-half of the AVM and the remainder is treated in the second stage, thus giving rise to a higher prescription dose for each stage. Therefore, the AVM, as a whole, could be given a higher dose than if the entire AVM were treated in a single fraction. In order to reproduce, in each stage, the isocenter coordinates determined from a pair of orthogonal films, two techniques are applied. One is the use of BrainLAB's...
Source: Journal of Radiosurgery - September 1, 2000 Category: Radiology Source Type: research
Treatment of Advanced Glaucomas Using Leksell Gamma Knife (LGK)--A Pilot Clinical Study
Abstract
The use of radiosurgery in treatment of the glaucomas is a completely new way of treating advanced stages of this treacherous disease. Up to now, the most common indications for the LGK therapy in ophthalmology at our department are malignant melanoma, vascular diseases, intraocular and intraorbital metastasis, and glioma of the optic nerve. Our pilot study shows that focal irradiation of the ciliary body in advanced glaucoma can ameliorate the main symptoms and thus prevent the otherwise inevitable enucleation of the eye. We treated in 12 patients, 13 very painful eyes, who were blind or with ...
Source: Journal of Radiosurgery - September 1, 2000 Category: Radiology Source Type: research
Metastatic Hepatoma to the Brain Treated with Stereotactic Radiosurgery
We report a case of hepatocellular carcinoma metastatic to the brain treated with stereotactic radiosurgery. This patient's tumors showed an excellent response to this modality and were successfully controlled for 13 months when she died of disseminated lung metastases. (Source: Journal of Radiosurgery)
Source: Journal of Radiosurgery - September 1, 2000 Category: Radiology Source Type: research
Brief Commentary Treating Brain Metastases from Hepatoma with Stereotactic Radiosurgery
(Source: Journal of Radiosurgery)
Source: Journal of Radiosurgery - September 1, 2000 Category: Radiology Source Type: research
Permanent I Interstitial Radiation Therapy in the Treatment of Non-GBM High-Grade Gliomas
This study evaluates prognostic factors influencing survival outcomes for 50 patients with permanent125 iodine-125 implants in the primary treatment of non-GBM high-grade gliomas. Stereotactic treatment planning aimed to encompass the contrast-enhancing rim of the tumor visualized by CT, with an initial dose rate of 0.05 Gy/hour with125I, delivering 100 Gy at 1 year and 103.68 Gy at infinity. Survival was evaluated using the Kaplan –Meier method for unvariate analysis and the Cox regressional method for multivariate analysis. In addition to the implant, 31 patients received external radiation therapy (5000 to 6000 cGy) b...
Source: Journal of Radiosurgery - June 1, 2000 Category: Radiology Source Type: research
A Study and Automatic Solution for Multishot Treatment Planning for the γ-Knife
AbstractIt is recognized that multiple-shot radiosurgery using the Leksell Gamma Knife (LGK) can result in larger penumbra dose and less target dose homogeneity compared with a single shot treatment. In addition, the number of shots used increases significantly with increasing volume, which makes planning and optimization time consuming and complex. Although such complexity may not affect the accuracy of treatment delivery itself, it is difficult to assess the dosimetrical merits of a given plan. To deal with this complicated process, we have studied shot-related effects and target shape as separate issues. Shot-related ef...
Source: Journal of Radiosurgery - June 1, 2000 Category: Radiology Source Type: research
Editorial About the Committee on Publication Ethics (COPE)
(Source: Journal of Radiosurgery)
Source: Journal of Radiosurgery - June 1, 2000 Category: Radiology Source Type: research
Results of γ-Knife Radiosurgery of Brain Arteriovenous Malformations
AbstractBetween 1992 and 1996 γ-knife radiosurgery was performed on 192 patients with the diagnosis of brain intracerebral arteriovenous malformations (AVM) at Na Homolce Hospital, Prague. The largest diameter of the nidus ranged between 0.6–5.4 cm, median 2.2 cm. The nidus volume ranged 0.15–28.6 cm2, median 3.9 cm2. Thus far, the angiographic evaluation after radiosurgery was performed in 162 patients. The treatment result reference was defined as follows: the interval with a lower limit represented by the percentage of the complete obliteration in the whole group of patients and the upper limit represented by the p...
Source: Journal of Radiosurgery - June 1, 2000 Category: Radiology Source Type: research
The Use of Radiochromic Film in Treatment Verification of Proton Radiosurgery
AbstractThis paper describes the use of a MD-55 radiochromic film to measure proton doses and dose distributions in a homogeneous lucite phantom. Radiosurgery dose distributions were measured for the plateau and for the Bragg peak techniques with narrow proton beams. Measured distributions were compared to the dose distributions calculated with a 3-D image-based treatment planning system developed at Loma Linda University Medical Center, California and modified to accommodate to treatment delivery apparatus used at the Institute of Theoretical and Experimental Physics, Moscow, Russia. The results of this comparison indicat...
Source: Journal of Radiosurgery - June 1, 2000 Category: Radiology Source Type: research
Poor-Prognosis Patients with Cancer Metastatic to Brain: Implications for Stereotactic Radiosurgery
AbstractThe risk of brain recurrence after whole-brain radiotherapy for metastatic disease has been infrequently reported, but quoted to be as high as 50%. These values are in the context of autopsy series or clinical trials and thus may not represent experience in routine clinical practice. This retrospective analysis was undertaken: (1) to confirm recursive analysis-based prognostic factors contributing to survival; and (2) to investigate efficacy of Gamma Knife Stereotactic Radiosurgery (GKSRS) in the poorest prognosis population. The records of 85 unselected, consecutive patients receiving whole-brain radiotherapy for ...
Source: Journal of Radiosurgery - June 1, 2000 Category: Radiology Source Type: research
