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Muscarinic M1 receptors stimulated by intracerebroventricular administration of McN-A-343 reduces the nerve injury-induced mechanical hypersensitivity via GABAB receptors rather than GABAA receptors in mice
Publication date: Available online 28 June 2019Source: Journal of Pharmacological SciencesAuthor(s): Keisuke Migita, Akiko Nishimura, Fumihiro Eto, Kohei Koga, Taichi Matsumoto, Kazuki Terada, Shuji Hara, Kenji HondaAbstractCholinergic neurons play an important role in the higher functions of the brain, such as the memory, cognition, and nociception. However, the exact mechanism behind how the stimulation of all the muscarinic M1 receptors in the entire brain results in the alleviation of partial sciatic nerve ligation (PSNL)-induced mechanical hypersensitivity has not been investigated. Thus, we examined which subtype of ...
Source: Journal of Pharmacological Sciences - June 28, 2019 Category: Drugs & Pharmacology Source Type: research

Chronic memantine administration prevents ouabain-induced hyperactivity in mice via maintenance of Na+, K+-ATPase activity in the hippocampus
Publication date: Available online 21 June 2019Source: Journal of Pharmacological SciencesAuthor(s): Yuki Kurauchi, Taishi Yamada, Akinori Hisatsune, Takahiro Seki, Hiroshi KatsukiAbstractWe have previously reported that mice received intracerebroventricular injection of ouabain, an inhibitor of Na+, K+-ATPase, exhibited hyperactivity via overactivation of glutamatergic neurons. Here we investigated the effects of memantine, a blocker of N-methyl-d-aspartate receptors, on ouabain-induced hyperactivity. In mice that received ouabain injection, chronic memantine administration prevented the hyperactivity and the decrease in ...
Source: Journal of Pharmacological Sciences - June 22, 2019 Category: Drugs & Pharmacology Source Type: research

Systematic expression analysis of genes related to generation of action potentials in human iPS cell-derived cardiomyocytes
Publication date: Available online 21 June 2019Source: Journal of Pharmacological SciencesAuthor(s): Masami Kodama, Kazuharu Furutani, Reiko Kimura, Tomoko Ando, Kazuho Sakamoto, Shushi Nagamori, Takashi Ashihara, Yoshihisa Kurachi, Yuko Sekino, Tetsushi Furukawa, Yasunari Kanda, Junko KurokawaAbstractHuman induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are a valuable tool to characterize the pharmacology and toxic effects of drugs on heart cells. In particular, hiPSC-CMs can be used to identify drugs that generate arrhythmias. However, it is unclear whether the expression of genes related to generation o...
Source: Journal of Pharmacological Sciences - June 22, 2019 Category: Drugs & Pharmacology Source Type: research

Extracellular Ca2+ promotes nitric oxide production via Ca2+-sensing receptor-Gq/11 protein-endothelial nitric oxide synthase signaling in human vascular endothelial cells
This study examined the possible involvement of Ca2+-sensing receptor (CaSR) in nitric oxide (NO) production in human vascular endothelial cells. Extracellular Ca2+ elevated the intracellular Ca2+ concentration, the endothelial NO synthase (eNOS) phosphorylation level, and NO release from the cells. These responses were inhibited by a CaSR antagonist and a Gq/11 protein inhibitor. Application of an endothelial cell suspension induced vasorelaxation in isolated rat thoracic aorta precontracted by phenylephrine. Adding an NO scavenger to the organ bath abolished this vasorelaxation response. These results suggest that extrac...
Source: Journal of Pharmacological Sciences - June 22, 2019 Category: Drugs & Pharmacology Source Type: research

Editorial Board
Publication date: May 2019Source: Journal of Pharmacological Sciences, Volume 140, Issue 1Author(s): (Source: Journal of Pharmacological Sciences)
Source: Journal of Pharmacological Sciences - June 19, 2019 Category: Drugs & Pharmacology Source Type: research