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Participation of PKG and PKA-related pathways in the IFN-γ induced modulation of the BKCa channel activity in human cardiac fibroblasts
This study was devoted to elucidating the interferon (IFN)-γ-induced signaling pathway and the interaction between protein kinase G (PKG) and protein kinase A (PKA) through large-conductance Ca(2+)-activated K(+) channels in human cardiac fibroblasts. The IK currents were recorded using a whole-cell patch clamp method. A large depolarization (+50 mV) and a high Ca2+ concentration (pCa 6.0) were used in the internal pipette solution to activate only the KCa channels. Iberiotoxin (Ibtx), which selectively inhibits BKCa channels at a concentration of 100 nmol/l, caused a significant reduction of basal IK. Adding IFN-γ in th...
Source: Journal of Pharmacological Sciences - August 31, 2019 Category: Drugs & Pharmacology Source Type: research

Effects of 2'-3'-dihydroxy-4',6'-dimethoxychalcone derived from green perilla on auricle thickness in chronic contact dermatitis model mice
Publication date: Available online 28 August 2019Source: Journal of Pharmacological SciencesAuthor(s): Yuki Takada-Takatori, Yuka Takeda, Risa Imai, Yasuhiko Izumi, Akinori Akaike, Katsuharu Tsuchida, Toshiaki KumeAbstractOxidative stress has been implicated in the pathogenesis of allergic contact dermatitis. The nuclear factor erythroid 2-related factor 2 (Nrf2)-antioxidant response element (ARE) pathway, an in vivo antioxidant system, induces antioxidant enzymes. In our previous studies, we isolated 2ʹ,3ʹ-dihydroxy-4ʹ,6ʹ-dimethoxychalcone (DDC) from green perilla and identified it as a novel activator of the Nrf2-ARE...
Source: Journal of Pharmacological Sciences - August 29, 2019 Category: Drugs & Pharmacology Source Type: research

Continued exposure of anti-cancer drugs to human iPS cell-derived cardiomyocytes can unmask their cardiotoxic effects
Publication date: Available online 27 August 2019Source: Journal of Pharmacological SciencesAuthor(s): Kazuho Sakamoto, Kohei Sakatoku, Shintaro Sugimoto, Nanami Iwasaki, Yusuke Sano, Masahiko Yamaguchi, Junko KurokawaAbstractAlthough the cardiotoxicity of anti-cancer drugs is an important issue, the underlying mechanisms remain unknown. To develop a sensitive assay system for cardiotoxicity, we examined effects of anti-cancer drugs on contractile functions of human iPS cell-derived cardiomyocytes by using non-invasive motion field imaging analysis with extended drug exposure time. We succeeded in continuously measuring st...
Source: Journal of Pharmacological Sciences - August 28, 2019 Category: Drugs & Pharmacology Source Type: research

Involvement of the persistent Na+ current in the diastolic depolarization and automaticity of the guinea pig pulmonary vein myocardium
In conclusion, late INa is involved in the diastolic depolarization and automaticity of the pulmonary vein myocardium. Late INa inhibitors appear to be effective therapeutic agents for atrial fibrillation with minimum adverse effects on the working myocardium. (Source: Journal of Pharmacological Sciences)
Source: Journal of Pharmacological Sciences - August 27, 2019 Category: Drugs & Pharmacology Source Type: research

Evaluation of the susceptibility of neurons and neural stem/progenitor cells derived from human induced pluripotent stem cells to anticancer drugs
In this study, we differentiated hiPSC-NSPCs into neurons and evaluated the susceptibility of hiPSC-neurons and parental hiPSC-NSPCs to anticancer drugs in vitro by ATP assay and immunocytostaining. The hiPSC-neurons were more resistant to anticancer drugs than the parental hiPSC-NSPCs. In the toxicity tests, high-dose cisplatin reduced the levels of ELAVL3/4, a neuronal marker, in the hiPSC-neurons. These results suggest that our methodology is potentially applicable for efficient determination of the toxicity of any drug to hiPSC-neurons. (Source: Journal of Pharmacological Sciences)
Source: Journal of Pharmacological Sciences - August 21, 2019 Category: Drugs & Pharmacology Source Type: research

Electrophysiological Characterization of a Small Molecule Activator on Human Ether-a-go-go-Related Gene (hERG) Potassium Channel
In conclusion, we identified a novel hERG channel activator HW-0168 that can be used for studying the physiological role of hERG in cardiac myocytes and may be beneficial for treating long QT syndrome. (Source: Journal of Pharmacological Sciences)
Source: Journal of Pharmacological Sciences - August 15, 2019 Category: Drugs & Pharmacology Source Type: research

Novel mouse model for evaluating in vivo efficacy of xCT inhibitor
Publication date: Available online 3 August 2019Source: Journal of Pharmacological SciencesAuthor(s): Ryosuke Yoshioka, Yusuke Fujieda, Yamato Suzuki, Osamu Kanno, Asako Nagahira, Tomohiro Honda, Masao Murakawa, Hiroshi YukiuraAbstractxCT, a well-known cystine transporter, is reported to be involved in the proliferation of various cells, such as cancer cells, immune cells, and fibroblasts. xCT inhibitor is expected to be a promising drug for cancer or immune diseases. However, there are little studies reporting that xCT inhibitors improve disease progression in vivo. To invent potent xCT inhibitors in vivo, we establishe...
Source: Journal of Pharmacological Sciences - August 10, 2019 Category: Drugs & Pharmacology Source Type: research

Targeted juglone blocks the invasion and metastasis of HPV-positive cervical cancer cells
This study was designed to acquire an understanding of the mechanism of invasion and metastasis in HPV-positive cells suppressed by juglone.It provides evidence of the advantageous use of juglone in the future.Graphical abstract (Source: Journal of Pharmacological Sciences)
Source: Journal of Pharmacological Sciences - August 10, 2019 Category: Drugs & Pharmacology Source Type: research

Cognitive enhancer ST101 improves schizophrenia-like behaviors in neonatal ventral hippocampus-lesioned rats in association with improved CaMKII/PKC pathway
Publication date: Available online 8 August 2019Source: Journal of Pharmacological SciencesAuthor(s): Yasushi Yabuki, Lei Wu, Kohji FukunagaAbstractAtypical antipsychotics improve positive and negative symptoms but are not effective for treating cognitive impairments in patients with schizophrenia. We previously reported that cognitive impairments in neonatal ventral hippocampus (NVH)-lesioned rats show resistance to atypical antipsychotics risperidone and are associated with reduced calcium/calmodulin-dependent protein kinase II (CaMKII) and protein kinase C (PKC) signaling in memory-related regions. The cognitive enhance...
Source: Journal of Pharmacological Sciences - August 9, 2019 Category: Drugs & Pharmacology Source Type: research

LncRNA RMRP accelerates hypoxia-induced injury by targeting miR-214-5p in H9c2 cells
Conclusion: our findings demonstrated the novel molecular mechanism of RMRP/miR-214-5p/p53 axis on the regulation of hypoxia-induced myocardial injury in H9c2 cells, which might provide potential therapeutic targets for AMI treatment. (Source: Journal of Pharmacological Sciences)
Source: Journal of Pharmacological Sciences - August 8, 2019 Category: Drugs & Pharmacology Source Type: research

GdCl3 attenuates the glomerular sclerosis of streptozotocin (STZ) induced diabetic rats via inhibiting TGF-β/Smads signal pathway
In this study, we found that GdCl3 which was an agonist of Calcium-sensing receptor (CaSR) could repress the activation of TGF-β/Smads signal pathway induced by TGF-β1 or high glucose and then alleviated the accumulation of extracellular matrix (ECM) in mesangial cells and the kidney of type1 diabetic rats. Further study indicated that GdCl3 could induce the binding of CaSR and TβR II and then both of these two receptors translocated from cell membrane to cytoplasm, in this case, TβR II on the cell membrane was decreased and then desensitized to the stimulation of its ligand TGF-β1, so that the activation of its downs...
Source: Journal of Pharmacological Sciences - August 7, 2019 Category: Drugs & Pharmacology Source Type: research

Genetic deletion of Cav3.2 T-type calcium channels abolishes H2S-dependent somatic and visceral pain signaling in C57BL/6 mice
Publication date: Available online 30 July 2019Source: Journal of Pharmacological SciencesAuthor(s): Kazuki Matsui, Maho Tsubota, Saaya Fukushi, Nene Koike, Hiroshi Masuda, Yoshihito Kasanami, Takaya Miyazaki, Fumiko Sekiguchi, Tsuyako Ohkubo, Shigeru Yoshida, Yutaro Mukai, Akira Oita, Mitsutaka Takada, Atsufumi KawabataAbstractWe tested whether genetic deletion of Cav3.2 T-type Ca2+ channels abolishes hydrogen sulfide (H2S)-mediated pain signals in mice. In Cav3.2-expressing HEK293 cells, Na2S, an H2S donor, at 100 μM clearly increased Ba2+ currents, as assessed by whole-cell patch-clamp recordings. In wild-type C57BL...
Source: Journal of Pharmacological Sciences - August 5, 2019 Category: Drugs & Pharmacology Source Type: research

Effects of progesterone on hypoxia-induced inhibition of excitatory synaptic transmission in the rat nucleus tractus solitarius
Publication date: Available online 3 August 2019Source: Journal of Pharmacological SciencesAuthor(s): Yoshiaki Ohi, Daisuke Kodama, Akira HajiAbstrsctThe present study evaluated the ability of progesterone to alleviate the synaptic transmission disturbed by hypoxia in the nucleus tractus solitarius (NTS). Hypoxia with N2 inhibited spontaneous and tractus solitarius-evoked excitatory postsynaptic currents (sEPSCs and eEPSCs) in NTS neurons of the rat brainstem slice. An additional application of progesterone counteracted the hypoxia-induced inhibition of sEPSCs and eEPSCs without affecting the baseline currents. This effect...
Source: Journal of Pharmacological Sciences - August 3, 2019 Category: Drugs & Pharmacology Source Type: research

Novel mouse model for evaluating in vivo efficacy of xCT inhibitor
Publication date: Available online 3 August 2019Source: Journal of Pharmacological SciencesAuthor(s): Ryosuke Yoshioka, Yusuke Fujieda, Yamato Suzuki, Osamu Kanno, Asako Nagahira, Tomohiro Honda, Masao Murakawa, Hiroshi YukiuraAbstractxCT, a well-known cystine transporter, is reported to be involved in the proliferation of various cells, such as cancer cells, immune cells, and fibroblasts. xCT inhibitor is expected to be a promising drug for cancer or immune diseases. However, there are little studies reporting that xCT inhibitors improve disease progression in vivo. To invent potent xCT inhibitors in vivo, we established ...
Source: Journal of Pharmacological Sciences - August 3, 2019 Category: Drugs & Pharmacology Source Type: research

Editorial Board
Publication date: June 2019Source: Journal of Pharmacological Sciences, Volume 140, Issue 2Author(s): (Source: Journal of Pharmacological Sciences)
Source: Journal of Pharmacological Sciences - August 2, 2019 Category: Drugs & Pharmacology Source Type: research