Journal of Medical Hypotheses and Ideas This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Is mobile phone radiofrequency radiation all bad?
Publication date: January 2014 Source:Journal of Medical Hypotheses and Ideas, Volume 8, Issue 1 Author(s): S.M.J. Mortazavi (Source: Journal of Medical Hypotheses and Ideas)
Source: Journal of Medical Hypotheses and Ideas - November 3, 2014 Category: Research Source Type: research

Opposing effect of amniotic membrane on angiogenesis originating from amniotic epithelial cells
Publication date: January 2014 Source:Journal of Medical Hypotheses and Ideas, Volume 8, Issue 1 Author(s): Hassan Niknejad , Ghasem Yazdanpanah There are controversies about the effects of amniotic membrane (AM) on angiogenesis. It was recently hypothesised that denuded AM (without epithelial cells) can induce angiogenesis. The results from the dorsal skinfold chamber method in an animal model and aortic ring assay showed that the epithelial side of the AM inhibits vessel sprouting and reduces capillary numbers, while the mesenchymal side of the AM increases angiogenesis. These data answered the controversies about ...
Source: Journal of Medical Hypotheses and Ideas - November 3, 2014 Category: Research Source Type: research

A novel device for extracting chyme from gastric cavity
Publication date: January 2014 Source:Journal of Medical Hypotheses and Ideas, Volume 8, Issue 1 Author(s): Ai-Juan Shen , Hai-Lin Zhu , Jian-Hua Duan , Min Zou , Ying Jiang Negative pressure drainage (NPD) technology is required to extract chyme from the gastric cavity of the patient suffering from stomach disease in order to observe the mucosal condition of the gastric cavity clearly and to avoid being misdiagnosed in gastroscopy. However, there are problems, such as insufficient vacuum and easy clogging, in the current NPD devices. To deal with these problems, by applying the principle of hydraulic check valve,...
Source: Journal of Medical Hypotheses and Ideas - November 3, 2014 Category: Research Source Type: research

Human endometrial adult stem cells can be differentiated into hepatocyte cells
Publication date: January 2014 Source:Journal of Medical Hypotheses and Ideas, Volume 8, Issue 1 Author(s): Farzaneh Khademi , Javad Verdi , Masoud Soleimani , Reza Roozafzoon , Saeed Heidari Keshel , Reza Raeisossadati , Jafar Ai Liver transplantation is the only choice for patients with end-stage liver diseases. Hepatocyte transplantation is a promising alternative for treatment of these groups. However, the major challenge is insufficiency of donor organs that can provide good-quality cells. Therefore, numerous experimental and clinical studies have evaluated the potential of different sources of adult stem c...
Source: Journal of Medical Hypotheses and Ideas - November 3, 2014 Category: Research Source Type: research

Repair of spinal cord injury by hypoxia-inducible factor-1a-expressing neural stem cells
Publication date: January 2014 Source:Journal of Medical Hypotheses and Ideas, Volume 8, Issue 1 Author(s): Lei Wang , Da Duan , Zhenyu Zhao , Xiaohua Teng , Lite Ge , Bin Liu , Ming Lu Neural stem cell (NSC) transplantation is an effective method of giving a supplement of cells lost and promoting functional recovery after spinal cord injury (SCI). Nonetheless, owing to hostile environments at the injury site, such as ischaemic hypoxia conditions and inflammatory cytokines, poor cell survival and uncontrolled differentiation are consistent problems encountered following NSC transplantation in ischaemic neural ti...
Source: Journal of Medical Hypotheses and Ideas - November 3, 2014 Category: Research Source Type: research

Fibroblast growth factor-21 may be a potential novel drug for preventing the development of traumatic TMJ bony ankylosis
Publication date: January 2014 Source:Journal of Medical Hypotheses and Ideas, Volume 8, Issue 1 Author(s): Su-Xia Liang , Ying-Bin Yan Trauma is the leading cause of temporomandibular joint (TMJ) bony ankylosis. The treatment of the condition poses a significant challenge because of the high incidence of recurrence. We previously proposed a new view that the development of traumatic TMJ bony ankylosis may be a course similar to hypertrophic nonunion, and the ensuing animal experiments preliminarily verified this view through histological analysis and molecular biology examination. In view of the similarity between b...
Source: Journal of Medical Hypotheses and Ideas - November 3, 2014 Category: Research Source Type: research

Simple and accessible screening method for congenital thrombopathies using an impedance haematology counter – reply: The differences between impedance aggregometry in whole blood versus aggregometry in PRP. Is there a need for caution?
Publication date: January 2014 Source:Journal of Medical Hypotheses and Ideas, Volume 8, Issue 1 Author(s): Ingrid Skornova , Jan Stasko , Amalia Ocenasova , Peter Kubisz Brahimi et al. in this journal formed a hypothesis that “the platelet count is underestimated, by an automated cell counter, each time platelet aggregates are present in the sample tube.” The addition of a platelet agonist to a stimulated sample tube will lead to the formation of platelet aggregates and hence to a drop in the platelet count. In the case of a hereditary platelet dysfunction, platelet aggregates cannot be formed upon addition of...
Source: Journal of Medical Hypotheses and Ideas - November 3, 2014 Category: Research Source Type: research

Antiangiogenic effect of silicate nanoparticles on corneal neo-vascularisation induced by vascular endothelial growth factor
Publication date: January 2014 Source:Journal of Medical Hypotheses and Ideas, Volume 8, Issue 1 Author(s): Mehrdad Mohammadpour , Mahmoud Jabbarvand , Elham Delrish , Ahad Khoshzaban Corneal neo-vascularisation (NV) is a major sight-threatening condition and is caused by infections, degenerative disorders, inflammation and long-time contact lens wear. Corneal NV occurs when the balance between angiogenic and antiangiogenic factors is tipped towards angiogenic molecules. The abnormal vessels may decrease corneal clarity and vision, lead to inflammation and corneal scarring and worsen the prognosis of penetrating ke...
Source: Journal of Medical Hypotheses and Ideas - November 3, 2014 Category: Research Source Type: research

Overexpression of MDA-7/IL-24 as an anticancer cytokine in gene therapy of thyroid carcinoma
Publication date: January 2014 Source:Journal of Medical Hypotheses and Ideas, Volume 8, Issue 1 Author(s): Mehri Hajikhan Mirzaei , Abdolreza Esmaeilzadeh The annual incidence of thyroid cancer worldwide is alarming. Despite current various treatments such as surgical resection, radioiodine therapy and chemotherapy/radiotherapy, thyroid carcinoma remains a lethal cancer. Assuredly, the operative and new treatment strategies are necessary to control this malignancy. Gene therapy is regarded as one of the most reliable novel therapeutic methods for hopeless cases of thyroid cancer and those who do not respond to the p...
Source: Journal of Medical Hypotheses and Ideas - November 3, 2014 Category: Research Source Type: research

Role of various flavonoids: Hypotheses on novel approach to treat diabetes
Publication date: January 2014 Source:Journal of Medical Hypotheses and Ideas, Volume 8, Issue 1 Author(s): S. Mohan , L. Nandhakumar Basically flavonoids are naturally occurring phenolic compounds that are distributed in plants. They contain wide range of biological activity and lot of research has been carried out on their potential role in treating diabetes and other diseases. Most importantly the flavonoids and their related natural compounds are known to encompass antidiabetic potential, demonstrated in various animal models. Such beneficial flavonoids are less utilized on account of its deprived solubility, dec...
Source: Journal of Medical Hypotheses and Ideas - November 3, 2014 Category: Research Source Type: research

Blocking IRES-mediated translation pathway as a new method to treat Alzheimer’s disease
Publication date: Available online 14 May 2014 Source:Journal of Medical Hypotheses and Ideas Author(s): Q.Y. Liu Scientists theorized that β-amyloid (Aβ) plaques and tau tangles are involved in the development of Alzheimer’s disease (AD), and amyloid precursor protein (APP) produces Aβ to trigger the disease process. However, the normal synaptic function of APP itself is not fully understood. Several findings cast APP as a potential key player in learning and memory under normal condition. Nevertheless, the regular operation of APP will be disrupted by abnormal accumulation of Aβ under cellular pathological con...
Source: Journal of Medical Hypotheses and Ideas - November 3, 2014 Category: Research Source Type: research

IL-24: A novel gene therapy candidate for immune system upregulation in Hodgkin’s lymphoma
Publication date: Available online 24 May 2014 Source:Journal of Medical Hypotheses and Ideas Author(s): Maryam Erfan Manesh , Abdolreza Esmaeilzadeh , Mehri Hajikhan Mirzaei Hodgkin’s Lymphoma (HL) as a prevalent hematolymphoid malignancy begins in cells of immune system and is characterized by the specific histologic, clinical properties. Abnormality in apoptosis has been recognized as a crucial pathway in its progression. Nowadays, 35–40% of patients in stages III and IV show disease relapse or symptoms of refractory to first-line chemotherapy; therefore, novel treatment strategies are required. As apoptosis ...
Source: Journal of Medical Hypotheses and Ideas - November 3, 2014 Category: Research Source Type: research

Science for the benefits of all: The way from idea to product
Publication date: July 2014 Source:Journal of Medical Hypotheses and Ideas, Volume 8, Issue 2 Author(s): Faheem Maqbool , Haji Bahadar , Mohammad Abdollahi Science is a knowledge based on hypotheses, observations, and experiments. From its very beginning science has served the humanity and will continue to do so until the needs of human being are fulfilled. History is rich of many scientists who have contributed to different fields of science free of politics, religion, cast, and region. Every human being must have the right to use science and technology for beneficial purposes. Mutual coordination between academia ...
Source: Journal of Medical Hypotheses and Ideas - November 3, 2014 Category: Research Source Type: research

Using three-dimensional porous internal titanium scaffold or allogenic bone scaffold for tissue-engineering condyle as a novel reconstruction of mandibular condylar defects
This article discusses the hypotheses. Graphical abstract Highlights (Source: Journal of Medical Hypotheses and Ideas)
Source: Journal of Medical Hypotheses and Ideas - November 3, 2014 Category: Research Source Type: research

The possible role of peripherally generated cross-reactive IgG in breakdown of the blood–brain barrier and initiation of multiple sclerosis
Publication date: July 2014 Source:Journal of Medical Hypotheses and Ideas, Volume 8, Issue 2 Author(s): Aram Mokarizadeh , Mohammad Abdollahi , Mohammad-Amin Rezvanfar , Mohammad-Reza Rahmani The initiating event in multiple sclerosis (MS) pathogenesis is not known yet. However, in general, breakdown of the blood-brain barrier (BBB) and subsequent infiltration of immune cells into the central nervous system (CNS) has been thought to be the main initiating event. Nonetheless, the mechanism by which the BBB gets disrupted and allows immune cells to infiltrate into the CNS is not fully understood. Evidence indicates ...
Source: Journal of Medical Hypotheses and Ideas - November 3, 2014 Category: Research Source Type: research