Journal of Medical Hypotheses and Ideas This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Counterbalancing immunosuppression-induced infections during long-term stay of humans in space
Publication date: January 2013 Source:Journal of Medical Hypotheses and Ideas, Volume 7, Issue 1 Author(s): S.M.J. Mortazavi , M. Motamedifar , G. Namdari , M. Taheri , A.R. Mortazavi The immune system is reported to be highly sensitive to different stressors that exist during space flight. Immune system dysregulation during and immediately following space missions is extensively reported. Solar and galactic radiation are among the major environmental factors which increase the risk of infection during extended stays of humans outside the Earth’s magnetic field. It has been reported that in addition to the effec...
Source: Journal of Medical Hypotheses and Ideas - November 3, 2014 Category: Research Source Type: research

A screening method for congenital thrombopathies using an impedance haematology counter
Publication date: January 2013 Source:Journal of Medical Hypotheses and Ideas, Volume 7, Issue 1 Author(s): Somsri Wiwanitkit , Viroj Wiwanitkit The screening method for congenital thrombopathies using an impedance haematology cell counter is a challenging proposal. However, there are two important concerns, the difference of analytical properties among different kinds of analysers and the use of a specific anticoagulant in the platelet parameter study. Graphical abstract Highlights ► The cell counter is a newly proposed tool for screening for congenital thrombopathies. ► There are many concerns on using...
Source: Journal of Medical Hypotheses and Ideas - November 3, 2014 Category: Research Source Type: research

Erythropoietin, heart disease and global rate
Publication date: January 2013 Source:Journal of Medical Hypotheses and Ideas, Volume 7, Issue 1 Author(s): Viroj Wiwanitkit In medicine, the relationship between erythropoietin and heart disease is sometimes mentioned. An attempt to demonstrate connection between erythropoietin and heart failure is very interesting. The attempt is based on the interrelationship among erythropoietin disturbance, anemia and heart disorder. However, the factors that can affect the endemic pattern must be considered. Graphical abstract Highlights ► Erythropoietin is well known for its relationship to anaemia and anaemia-relate...
Source: Journal of Medical Hypotheses and Ideas - November 3, 2014 Category: Research Source Type: research

Cancer nanotherapy: Concept for design of new drug
Publication date: January 2013 Source:Journal of Medical Hypotheses and Ideas, Volume 7, Issue 1 Author(s): Viroj Wiwanitkit Nanotherapy is an actual newest mode of treatment that can be applied for cancer therapy. To imagine and test the hypothesis and idea regarding the new hypothesised nanotherapeutic system, there are many issues to be addressed including the change of properties of substances at the nano-level, the use of in vitro studies for testing the new drug and the safety of the new nano-substance. Graphical abstract Highlights ► Nanotherapy is the newest mode of medical therapy. ► There are ma...
Source: Journal of Medical Hypotheses and Ideas - November 3, 2014 Category: Research Source Type: research

Space research and EMF-induced adaptive responses
Publication date: January 2013 Source:Journal of Medical Hypotheses and Ideas, Volume 7, Issue 1 Author(s): S.M.J. MortazaviHighlights ► The idea of performing adaptive response tests for choosing astronauts dates back to 2003. ► Based on early reports by Mortazavi et al. (2003), chronic space radiation acts as an adapting dose. ► These exposures can better protect astronauts against solar activities (adaptive response). ► Mortazavi et al. previously reported that radiofrequency radiation induces adaptive response. ► This adaptive response does not have an independent role in reducing deep space missions’ ...
Source: Journal of Medical Hypotheses and Ideas - November 3, 2014 Category: Research Source Type: research

A novel approach to eradicate latent TB: Based on resuscitation promoting factors
Publication date: July 2013 Source:Journal of Medical Hypotheses and Ideas, Volume 7, Issue 2 Author(s): Khaled Seidi , Rana Jahanban-Esfahlan Tuberculosis (TB) is a growing unsolved health concern, as it is the main infectious cause of death in the globe. The ability of the pathogen to develop into a dormant state is the main obstacle in overcoming the disease. It seems that the development of compounds that can target latent TB is the key to eradicate this pathogen. In this regard, many researchers started to search for novel compounds that could inhibit the activity of molecules involved in the resuscitation of la...
Source: Journal of Medical Hypotheses and Ideas - November 3, 2014 Category: Research Source Type: research

Hyperglycaemia alters thymic epithelial cell function
Publication date: July 2013 Source:Journal of Medical Hypotheses and Ideas, Volume 7, Issue 2 Author(s): Vera Alexandrovna Abramova , Nikolai Nikolaevich Belyaev Insulin-dependent diabetes mellitus (IDDM) is considered to be a consequence of unchecked auto-immune processes. Alterations in immune system responses are thought to be the cause of the disease, but the possibility that altered metabolite levels (glucose) can establish the disease by specifically acting on and altering thymus stroma functions has not been investigated. Therefore, the direct effect of hyperglycaemia (HG) on central tolerance mechanisms as a ...
Source: Journal of Medical Hypotheses and Ideas - November 3, 2014 Category: Research Source Type: research

MicroRNAs: Are they indicators for prediction of response to radiotherapy in breast cancer?
Publication date: July 2013 Source:Journal of Medical Hypotheses and Ideas, Volume 7, Issue 2 Author(s): Mohammad Halimi , Hadi Parsian , S. Mohsen Asghari , Reyhaneh Sariri , Dariush Moslemi , Farshid Yeganeh Radiotherapy is one of the most important methods for the treatment of breast cancer. There is great interest in identifying factors that help to predict patient response to radiotherapy. MicroRNAs (miRNAs) are a class of small RNA molecules that regulate gene expression at the post-transcriptional level and play a key role in cellular responses to ionising radiation. Several regulatory proteins participate...
Source: Journal of Medical Hypotheses and Ideas - November 3, 2014 Category: Research Source Type: research

Extracorporeal shock wave therapy could be a potential adjuvant treatment for orthopaedic implant-associated infections
Publication date: July 2013 Source:Journal of Medical Hypotheses and Ideas, Volume 7, Issue 2 Author(s): Xiao-feng Chen , Xiao-lin Li Over the past half-century, biomaterials have been used in orthopaedic surgery world widely, but orthopaedic implant-associated infections (OIAIs) are still a puzzle for orthopaedic surgeons, which may result in prolonged hospitalisation, poor functional status and high costs. The presence of implants increases the risk of microbial infection; moreover, the formation of bacterial biofilm leads to a higher resistance to antibiotics and local immune response. In such cases, conventional ...
Source: Journal of Medical Hypotheses and Ideas - November 3, 2014 Category: Research Source Type: research

Synergistic effect of probiotics, butyrate and l-Carnitine in treatment of IBD
Publication date: July 2013 Source:Journal of Medical Hypotheses and Ideas, Volume 7, Issue 2 Author(s): Mahsa Moeinian , Seyedeh Farnaz Ghasemi-Niri , Shilan Mozaffari , Mohammad Abdollahi Genetic, environmental factors, dysregulation of immune system, intestinal microbes and oxidative stress are the most important factors that play the role in the pathogenesis of inflammatory bowel disease (IBD). Current treatments do not always result in complete remission and usually accompanied with several adverse effects. Recent studies showed that nuclear factor-kappa B (NF-κB), tumor necrosis factor-α (TNF-α) and oxidat...
Source: Journal of Medical Hypotheses and Ideas - November 3, 2014 Category: Research Source Type: research

Proposed approach for revealing unknown mediators of the abscopal effect
Publication date: July 2013 Source:Journal of Medical Hypotheses and Ideas, Volume 7, Issue 2 Author(s): Khaled Seidi , Nosratollah Zarghami , Rana Jahanban-Esfahlan It is sometimes asserted, as a matter of dogma, that a local treatment cannot have systemic effects. However, treatment with radiotherapy directly localised on a tumour can profoundly affect tumour cells in the other tissues far from the radiated part. In 1953, Dr. Mole called this surprising phenomenon the ‘abscopal effect’. Since its discovery, very little is known about the exact mechanism and the key mediators of this astonishing phenomenon and ...
Source: Journal of Medical Hypotheses and Ideas - November 3, 2014 Category: Research Source Type: research

Eph–ephrin bidirectional signalling: A promising approach for osteoporosis treatment
Publication date: July 2013 Source:Journal of Medical Hypotheses and Ideas, Volume 7, Issue 2 Author(s): Shao Jin , Zhang Yan , Yang Tieyi , Liu Shuyi , Wu Liang , Ying Hui Osteoporosis is a common disease characterised by low bone density and brittle bone due to osteoblast–osteoclast uncoupling. The cellular and molecular mechanisms responsible for osteoblast–osteoclast coupling lead to the identification of novel therapeutic targets. The increasing evidence for a role for Eph–ephrin signalling in biological processes, including cell–cell interactions, cell morphology, cell migration, angiogenesis, cance...
Source: Journal of Medical Hypotheses and Ideas - November 3, 2014 Category: Research Source Type: research

Vitamin D as an effective treatment approach for drug abuse and addiction
Publication date: July 2013 Source:Journal of Medical Hypotheses and Ideas, Volume 7, Issue 2 Author(s): Jaqueline Kalleian Eserian Effective pharmacological treatments for drug abuse and addiction have not yet been identified. Evidences show that vitamin D may be involved in neurodevelopment and may have a neuroprotective effect on dopaminergic pathways in the adult brain. The fact that vitamin D increases the levels of tyrosine hydroxylase expression implies that vitamin D could modulate dopaminergic processes. Drugs of abuse act through different mechanisms of action and on different locations in the brain reward s...
Source: Journal of Medical Hypotheses and Ideas - November 3, 2014 Category: Research Source Type: research

Caspase inhibitors may attenuate opioid-induced hyperalgesia and tolerance via inhibiting microglial activation and neuroinflammation
Publication date: July 2013 Source:Journal of Medical Hypotheses and Ideas, Volume 7, Issue 2 Author(s): Zelin Weng , Yun Lin , Jiancheng Zhang , Shanglong Yao Prolonged exposure to an opioid induces hyperalgesia and tolerance, which negatively affect pain management in turn and significantly hamper the application of opioids. A growing body of evidence has demonstrated that glial activation contributes to the development of these two side effects. Recent studies have demonstrated that morphine, binding to an accessory protein of Toll-like receptor 4 (TLR4), activates microglia and produces neuroinflammation in a m...
Source: Journal of Medical Hypotheses and Ideas - November 3, 2014 Category: Research Source Type: research

Gliadin is an uncatalogued Toll-like receptor ligand
Publication date: January 2014 Source:Journal of Medical Hypotheses and Ideas, Volume 8, Issue 1 Author(s): Shirin Moossavi Coeliac disease is a chronic intestinal inflammatory condition, which is caused by an inappropriate immune response to components of wheat family cereals in a genetically susceptible host. Gliadins are the major pathogenic constituent of wheat; their toxicity and immunogenicity depend on their amino acid sequence. They are known to initiate the innate and the adaptive immune response. Nevertheless, it is not yet known how they are recognised by the intestinal epithelium and immune cells. Toll-lik...
Source: Journal of Medical Hypotheses and Ideas - November 3, 2014 Category: Research Source Type: research