Evaluation of SOX2 and podoplanin expression in oral epithelial dysplasia and its correlation with malignant transformation
ConclusionAlteration in SOX2 and podoplanin is likely an important event in head and neck carcinogenesis; however, their expression may be valuable only in a few cases of oral epithelial dysplasia to assess the risk of malignant transformation. (Source: Journal of Investigative and Clinical Dentistry)
Source: Journal of Investigative and Clinical Dentistry - November 22, 2019 Category: Dentistry Authors: Vani Verma, Chetana Chandrashekar Tags: ORIGINAL ARTICLE Source Type: research

Microbiota of periodontal pockets and root canals in induced experimental periodontal disease in dogs
ConclusionMicrobial composition of the RC could be modulated by the presence of periodontal disease, especially in cases of severe periodontal destruction. RC microbiota was less complex and diverse than the PP. (Source: Journal of Investigative and Clinical Dentistry)
Source: Journal of Investigative and Clinical Dentistry - November 22, 2019 Category: Dentistry Authors: C ícero R. Gadê‐Neto, Ronaldo R. Rodrigues, Lidiane M. Louzada, Rodrigo Arruda‐Vasconcelos, Fabrício B. Teixeira, Renato C. Viana Casarin, Brenda P. F. A. Gomes Tags: ORIGINAL ARTICLE Source Type: research

Oral candidal carriage correlates with CD4+ cell count but not with HIV and highly active antiretroviral therapy status
ConclusionHIV status results in significantly elevated rates of OCCC  albicans remains the predominant pathogen, although other species are emerging rapidly. Resistance to fluconazole is on the rise, and more efficient treatment strategies need to be implemented. (Source: Journal of Investigative and Clinical Dentistry)
Source: Journal of Investigative and Clinical Dentistry - November 22, 2019 Category: Dentistry Authors: Parul Sah, Pratik Patel, Chetana Chandrashekar, Suganthi Martena, Mamatha Ballal, Manjayya Hegde, Vasudeva Guddattu, Craig Murdoch, Mohit Sharma, Raghu Radhakrishnan Tags: ORIGINAL ARTICLE Source Type: research

Epidemiological profile of young patients with squamous cell carcinoma in northeast Brazil
ConclusionSCC in young patients is more common in males aged 46  ± 7.94 years, with the tongue being the most affected anatomic site. Important differences were found in clinical‐epidemiological features between young men and women. (Source: Journal of Investigative and Clinical Dentistry)
Source: Journal of Investigative and Clinical Dentistry - November 22, 2019 Category: Dentistry Authors: Karen Rayssa Borba Ribeiro, Cledinaldo Lira J únior, Sandra Aparecida Marinho, Sérgio Henrique Gonçalves Carvalho, Gustavo Gomes Agripino, Dmitry José de Santana Sarmento Tags: ORIGINAL ARTICLE Source Type: research

Fracture resistance, gap and void formation in root ‐filled mandibular molars restored with bulk‐fill resin composites and glass‐ionomer cement base
ConclusionConventional and bulk ‐fill resin composites provided similar fracture resistance and gaps/voids in root‐filled molars with MO cavities. Placing a GIC base decreased fracture resistance and increased gap/void formation. (Source: Journal of Investigative and Clinical Dentistry)
Source: Journal of Investigative and Clinical Dentistry - November 22, 2019 Category: Dentistry Authors: Nathamon Thongbai ‐on, Kanet Chotvorrarak, Danuchit Banomyong, Michael F. Burrow, Sittichoke Osiri, Nattha Pattaravisitsate Tags: ORIGINAL ARTICLE Source Type: research

Comparative evaluation of curcumin and antioxidants in the management of oral submucous fibrosis
ConclusionWhen administrated in both systemic and topical forms together, curcumin showed better results in the management of oral submucous fibrosis as compared with the systemic form alone or antioxidants. Curcumin has the potential to emerge as an effective alternative to conventionally prescribed medications. (Source: Journal of Investigative and Clinical Dentistry)
Source: Journal of Investigative and Clinical Dentistry - November 22, 2019 Category: Dentistry Authors: Arpita Rai, Mandeep Kaur, Virender Gombra, Shamimul Hasan, Narender Kumar Tags: ORIGINAL ARTICLE Source Type: research

Clinical and patient ‐centered outcomes post non‐surgical periodontal therapy with the use of a non‐injectable anesthetic product: A randomized clinical study
ConclusionThe present study suggested that the modification of the standard FMD could improve the clinical efficacy of non ‐injectable anesthetic, along with patients’ short‐ and mid‐term appreciation and compliance. (Source: Journal of Investigative and Clinical Dentistry)
Source: Journal of Investigative and Clinical Dentistry - November 22, 2019 Category: Dentistry Authors: Simone Marconcini, Marilyn Goulding, Giacomo Oldoini, Chiara Attanasio, Enrica Giammarinaro, Annamaria Genovesi Tags: ORIGINAL ARTICLE Source Type: research

Changes in oral microbial profiles associated with oral squamous cell carcinoma vs leukoplakia
ConclusionThese changes in the salivary microbiome may have potential applications as a novel diagnostic tool for the early detection of OSCC. (Source: Journal of Investigative and Clinical Dentistry)
Source: Journal of Investigative and Clinical Dentistry - November 22, 2019 Category: Dentistry Authors: Kengo Hashimoto, Dai Shimizu, Sho Hirabayashi, Sei Ueda, Satoru Miyabe, Ichiro Oh ‐iwa, Toru Nagao, Kazuo Shimozato, Shuji Nomoto Tags: ORIGINAL ARTICLE Source Type: research

Ki67, CD105 and α‐smooth muscle actin expression in disease progression model of oral submucous fibrosis
ConclusionKi67 LI, α‐SMA and CD105 expression alone or together correspond with the disease progression model of SMF. Hence, expression of these markers can be used as a predictive marker of clinical outcome of OSCC‐SMF. (Source: Journal of Investigative and Clinical Dentistry)
Source: Journal of Investigative and Clinical Dentistry - November 22, 2019 Category: Dentistry Authors: Amol R. Gadbail, Minal S. Chaudhary, Sachin C. Sarode, Shailesh M. Gondivkar, Lalita Belekar, Mugdha P. Mankar ‐Gadbail, Ravi Dande, Satyajit A. Tekade, Monal B. Yuwanati, Shankargouda Patil Tags: ORIGINAL ARTICLE Source Type: research

The Periodontal ‐Cardiovascular alliance: Evaluation of miRNA‐146a in subgingival plaque samples of chronic periodontitis patients with and without coronary heart disease
ConclusionmiRNA ‐146a is involved in the pathogenesis of both periodontitis and coronary heart disease. (Source: Journal of Investigative and Clinical Dentistry)
Source: Journal of Investigative and Clinical Dentistry - November 22, 2019 Category: Dentistry Authors: Krutika Yagnik, Jaideep Mahendra, V. M. Kurian Tags: ORIGINAL ARTICLE Source Type: research

Association of vitamin D receptor gene polymorphism (rs10735810) and chronic periodontitis
ConclusionThe present study denotes that theVDR polymorphism (rs10735810) is not associated with CP in the study group analyzed. (Source: Journal of Investigative and Clinical Dentistry)
Source: Journal of Investigative and Clinical Dentistry - November 22, 2019 Category: Dentistry Authors: Karthikeyan Murthykumar, Radhika Arjunkumar, Vijayashree Priyadharsini Jayaseelan Tags: ORIGINAL ARTICLE Source Type: research

Evaluation of biologic implant success parameters in type 2 diabetic glycemic control patients versus healthy patients: A meta ‐analysis
ConclusionThe results of the present study indicated that, despite being glycemic controlled, patients with T2DM were associated with a higher risk of peri ‐implant disease. (Source: Journal of Investigative and Clinical Dentistry)
Source: Journal of Investigative and Clinical Dentistry - November 22, 2019 Category: Dentistry Authors: Victor L. Lagunov, Jing Sun, Roy George Tags: ORIGINAL ARTICLE Source Type: research

Risk assessments in orthodontic patients developing white spot lesions
ConclusionCases had greater sugar intake between meals than controls. ATP bioluminescence,Streptococcus mutans levels with Saliva Check Mutans, and salivary factors do not identify patients who develop WSL. (Source: Journal of Investigative and Clinical Dentistry)
Source: Journal of Investigative and Clinical Dentistry - November 22, 2019 Category: Dentistry Authors: Danielle K. Leeper, Amal Noureldin, Katie Julien, Phillip M. Campbell, Peter H. Buschang Tags: ORIGINAL ARTICLE Source Type: research

Use of sonic waves in bubble formation, microhardness and fluoride release of a high ‐viscosity glass‐ionomer cement
ConclusionThe use of sonic and ultrasonic waves had no influence on bubble formation, microhardness and fluoride release of a HV ‐GIC. Changing the P/L is not recommended. (Source: Journal of Investigative and Clinical Dentistry)
Source: Journal of Investigative and Clinical Dentistry - November 22, 2019 Category: Dentistry Authors: Nallu Gomes Lima Hironaka, Juliana Quintino Trizzi, Nat ália Miwa Yoshida, Jaime Aparecido Cury, Cinthia Pereira Machado Tabchoury, Juliana Nunes Botelho, Nubia Inocencya Pavesi Pini, Renata Corrêa Pascotto Tags: ORIGINAL ARTICLE Source Type: research

Evaluation of student use of videos to support learning in a simulation laboratory course: A perception and analytics approach
ConclusionVideos were reported to support student learning and were valued for a range of learning needs. However, significant differences between student consumption and strategies need to be designed to engage low consumers. (Source: Journal of Investigative and Clinical Dentistry)
Source: Journal of Investigative and Clinical Dentistry - November 22, 2019 Category: Dentistry Authors: Michael G. Botelho Tags: ORIGINAL ARTICLE Source Type: research