A novel model for brain iron uptake: introducing the concept of regulation
& James R Connor (Source: Journal of Cerebral Blood Flow and Metabolism)
Source: Journal of Cerebral Blood Flow and Metabolism - January 6, 2015 Category: Neuroscience Authors: Ian A SimpsonPadmavathi PonnuruMarianne E KlingerRoland L MyersKavi DevrajChristopher L CoeGabriele R LubachAnthony CarruthersJames R Connor Tags: blood–brain barrier mathematical modeling neurochemistry neurovascular unit neurovascular coupling receptors Source Type: research

Decreased expression of organic cation transporters, Oct1 and Oct2, in brain microvessels and its implication to MPTP-induced dopaminergic toxicity in aged mice
p; Chun-Jung Lin (Source: Journal of Cerebral Blood Flow and Metabolism)
Source: Journal of Cerebral Blood Flow and Metabolism - January 6, 2015 Category: Neuroscience Authors: Kuo-Chen WuYa-Hsuan LuYi-Hsuan PengTing-Fen TsaiYu-Han KaoHui-Ting YangChun-Jung Lin Tags: blood–brain barrier MPTP organic cation transporters Source Type: research

Poly(ADP-ribose) polymerase-1 inhibition in brain endothelium protects the blood–brain barrier under physiologic and neuroinflammatory conditions
Poly(ADP-ribose) polymerase-1 inhibition in brain endothelium protects the blood–brain barrier under physiologic and neuroinflammatory conditions Journal of Cerebral Blood Flow & Metabolism 35, 28 (January 2015). doi:10.1038/jcbfm.2014.167 Authors: Slava Rom, Viviana Zuluaga-Ramirez, Holly Dykstra, Nancy L Reichenbach, Servio H Ramirez & Yuri Persidsky (Source: Journal of Cerebral Blood Flow and Metabolism)
Source: Journal of Cerebral Blood Flow and Metabolism - January 6, 2015 Category: Neuroscience Authors: Slava RomViviana Zuluaga-RamirezHolly DykstraNancy L ReichenbachServio H RamirezYuri Persidsky Tags: BBB PARP endothelial dysfunction Source Type: research

Regional distribution of selective neuronal loss and microglial activation across the MCA territory after transient focal ischemia: quantitative versus semiquantitative systematic immunohistochemical assessment
Claude Baron (Source: Journal of Cerebral Blood Flow and Metabolism)
Source: Journal of Cerebral Blood Flow and Metabolism - January 6, 2015 Category: Neuroscience Authors: Julius V EmmrichSohail EjazJonas J NeherDavid J WilliamsonJean-Claude Baron Tags: brain ischemia immunohistochemistry inflammation selective neuronal death Source Type: research

Longitudinal changes in resting-state brain activity in a capsular infarct model
e & Hyoung-Ihl Kim (Source: Journal of Cerebral Blood Flow and Metabolism)
Source: Journal of Cerebral Blood Flow and Metabolism - January 6, 2015 Category: Neuroscience Authors: Donghyeon KimRa Gyung KimHyung-Sun KimJin-Myung KimSung Chan JunBoreom LeeHang Joon JoPedro R NetoMin-Cheol LeeHyoung-Ihl Kim Tags: cerebrovascular disease lacunar infarcts positron emission tomography rehabilitation white-matter disease Source Type: research

CD28 superagonist-mediated boost of regulatory T cells increases thrombo-inflammation and ischemic neurodegeneration during the acute phase of experimental stroke
; Christoph Kleinschnitz (Source: Journal of Cerebral Blood Flow and Metabolism)
Source: Journal of Cerebral Blood Flow and Metabolism - January 6, 2015 Category: Neuroscience Authors: Michael K SchuhmannPeter KraftGuido StollKristina LorenzSven G MeuthHeinz WiendlBernhard NieswandtTim SparwasserNiklas BeyersdorfThomas KerkauChristoph Kleinschnitz Tags: brain ischemia inflammation microcirculation T cells thrombosis Source Type: research

SUMO2/3 is associated with ubiquitinated protein aggregates in the mouse neocortex after middle cerebral artery occlusion
SUMO2/3 is associated with ubiquitinated protein aggregates in the mouse neocortex after middle cerebral artery occlusion Journal of Cerebral Blood Flow & Metabolism 35, 1 (January 2015). doi:10.1038/jcbfm.2014.180 Authors: Karin Hochrainer, Katherine Jackman, Corinne Benakis, Josef Anrather & Costantino Iadecola (Source: Journal of Cerebral Blood Flow and Metabolism)
Source: Journal of Cerebral Blood Flow and Metabolism - January 6, 2015 Category: Neuroscience Authors: Karin HochrainerKatherine JackmanCorinne BenakisJosef AnratherCostantino Iadecola Tags: ischemic stroke protein aggregation small ubiquitin-related modifier Source Type: research

[11C]befloxatone distribution is well correlated to monoamine oxidase A protein levels in the human brain
[11C]befloxatone distribution is well correlated to monoamine oxidase A protein levels in the human brain Journal of Cerebral Blood Flow & Metabolism 34, 1951 (December 2014). doi:10.1038/jcbfm.2014.157 Authors: Paolo Zanotti-Fregonara & Michel Bottlaender (Source: Journal of Cerebral Blood Flow and Metabolism)
Source: Journal of Cerebral Blood Flow and Metabolism - December 1, 2014 Category: Neuroscience Authors: Paolo Zanotti-FregonaraMichel Bottlaender Tags: monoamine oxidase A PET [11C]befloxatone brain imaging Source Type: research

Spectroscopy of reperfused tissue after stroke reveals heightened metabolism in patients with good clinical outcomes
& Mark W Parsons (Source: Journal of Cerebral Blood Flow and Metabolism)
Source: Journal of Cerebral Blood Flow and Metabolism - December 1, 2014 Category: Neuroscience Authors: Andrew BivardVenkatesh KrishnamurthyPeter StanwellNawaf YassiNeil J SprattMichael NilssonChristopher R LeviStephen DavisMark W Parsons Tags: acute stroke glutamate lactate MR spectroscopy perfusion-weighted MRI reperfusion regeneration and recovery Source Type: research

Hierarchical multivariate covariance analysis of metabolic connectivity
rry J Bedell (Source: Journal of Cerebral Blood Flow and Metabolism)
Source: Journal of Cerebral Blood Flow and Metabolism - December 1, 2014 Category: Neuroscience Authors: Felix CarbonellArnaud CharilAlex P ZijdenbosAlan C EvansBarry J Bedell Tags: Alzheimer’s disease β-amyloid covariance analysis FDG PET florbetapir PET metabolic connectivity mild cognitive impairment Source Type: research

Cellular origin and regulation of D- and L-serine in in vitro and in vivo models of cerebral ischemia
so & Norihiro Suzuki (Source: Journal of Cerebral Blood Flow and Metabolism)
Source: Journal of Cerebral Blood Flow and Metabolism - December 1, 2014 Category: Neuroscience Authors: Takato AbeMasataka SuzukiJumpei SasabeShinichi TakahashiMiyuki UnekawaKyoko MashimaTakuya IizumiKenji HamaseRyuichi KonnoSadakazu AisoNorihiro Suzuki Tags: excitotoxicity focal ischemia glial cells glutamate neuronal–glial interaction Source Type: research

Optimization and reliability of multiple postlabeling delay pseudo-continuous arterial spin labeling during rest and stimulus-induced functional task activation
; Irene Tracey (Source: Journal of Cerebral Blood Flow and Metabolism)
Source: Journal of Cerebral Blood Flow and Metabolism - December 1, 2014 Category: Neuroscience Authors: Melvin MezueAndrew R SegerdahlThomas W OkellMichael A ChappellMichael E KellyIrene Tracey Tags: ASL brain imaging cerebral blood flow measurement FMRI kinetic modeling physiology Source Type: research

Effect of increased oxygen tension on flicker-induced vasodilatation in the human retina
erhard Garhöfer (Source: Journal of Cerebral Blood Flow and Metabolism)
Source: Journal of Cerebral Blood Flow and Metabolism - December 1, 2014 Category: Neuroscience Authors: Stefan PalkovitsReinhard ToldAgnes BoltzDoreen SchmidlAlina Popa CherecheanuLeopold SchmettererGerhard Garhöfer Tags: hemodynamics neurovascular coupling physiology Source Type: research

In vivo imaging of reactive oxygen species in mouse brain by using [3H]Hydromethidine as a potential radical trapping radiotracer
In vivo imaging of reactive oxygen species in mouse brain by using [3H]Hydromethidine as a potential radical trapping radiotracer Journal of Cerebral Blood Flow & Metabolism 34, 1907 (December 2014). doi:10.1038/jcbfm.2014.160 Authors: Kohji Abe, Nozomi Takai, Kazumi Fukumoto, Natsumi Imamoto, Misato Tonomura, Miwa Ito, Naoki Kanegawa, Katsunori Sakai, Kenji Morimoto, Kenichiro Todoroki & Osamu Inoue (Source: Journal of Cerebral Blood Flow and Metabolism)
Source: Journal of Cerebral Blood Flow and Metabolism - December 1, 2014 Category: Neuroscience Authors: Kohji AbeNozomi TakaiKazumi FukumotoNatsumi ImamotoMisato TonomuraMiwa ItoNaoki KanegawaKatsunori SakaiKenji MorimotoKenichiro TodorokiOsamu Inoue Tags: in vivo molecular imaging radical trapping radiotracer reactive oxygen species Source Type: research

Differential Tiam1/Rac1 activation in hippocampal and cortical neurons mediates differential spine shrinkage in response to oxygen/glucose deprivation
Differential Tiam1/Rac1 activation in hippocampal and cortical neurons mediates differential spine shrinkage in response to oxygen/glucose deprivation Journal of Cerebral Blood Flow & Metabolism 34, 1898 (December 2014). doi:10.1038/jcbfm.2014.158 Authors: Elena Blanco-Suárez, Maria Fiuza, Xun Liu, Elavazhagan Chakkarapani & Jonathan G Hanley (Source: Journal of Cerebral Blood Flow and Metabolism)
Source: Journal of Cerebral Blood Flow and Metabolism - December 1, 2014 Category: Neuroscience Authors: Elena Blanco-SuárezMaria FiuzaXun LiuElavazhagan ChakkarapaniJonathan G Hanley Tags: cell death cortex dendritic spine hippocampus ischemia OGD Source Type: research