A Descriptive Study of the Temporal Patterns of Volume and Contents Change in Human Acute Burn Edema: Application in Evidence-Based Intervention and Research Design
Edema after burn contributes significantly to burn wound depth conversion. In humans after burn injury, there is a lack of detailed understanding of the contents and temporal changes in volume of acute tissue edema. The novel findings of these studies relate to the collection of edema fluid after partial-thickness burn injury. Edema volume peaks on day 1 after burn without formal fluid resuscitation. The studies indicated that the peak was on day 2 for a resuscitated burn. In contrast, animal studies suggest that the peak of edema occurs by or before day 1 after injury. The findings confirm the pitfalls of evidence derived...
Source: Journal of Burn Care and Research - September 1, 2016 Category: Rehabilitation Tags: Original Articles Source Type: research
Effects of Mesalamine Treatment on Gut Barrier Integrity After Burn Injury
In this study, the authors examined whether therapeutic intervention with mesalamine (5-aminosalicylic acid [5-ASA]), a common anti-inflammatory treatment for patients with inflammatory bowel disease, reduces intestinal inflammation and maintains normal barrier integrity after burn injury. Male C57BL/6 mice were administered an approximately 20% TBSA dorsal scald burn and resuscitated with either 1 ml normal saline or 100 mg/kg of 5-ASA dissolved in saline. The authors examined intestinal transit and permeability along with the levels of small intestine epithelial cell proinflammatory cytokines and tight junction prote...
Source: Journal of Burn Care and Research - September 1, 2016 Category: Rehabilitation Tags: Original Articles Source Type: research
Comparative Analysis of Early Excision and Grafting vs Delayed Grafting in Burn Patients in a Developing Country
The present study attempts to compare how the patients who undergo early excision and grafting behave as compared with patients who are treated along usual conservative lines of management in centers where the resources are less than optimal. The data of 20 female patients were analyzed. Age of the patients ranged between 20 and 30 years, percentage area burn ranged between 20 and 40%, and percentage area resurfaced by skin grafting 5 to 10%. The patients were divided into two groups of 10 patients each. Group I included those patients who underwent early excision and grafting within 5 days of burn injury. Group II include...
Source: Journal of Burn Care and Research - September 1, 2016 Category: Rehabilitation Tags: Original Articles Source Type: research
Long-Term Administration of Oxandrolone Improves Lung Function in Pediatric Burned Patients
Pulmonary dysfunction is a significant contributor to morbidity and mortality in the pediatric burned population. We have previously reported that the administration of a synthetic testosterone derivative, oxandrolone, significantly reduced hypermetabolism, and significantly increased height percentile, bone mineral content, lean body mass, and strength in pediatric burned patients. We hypothesize that the administration of oxandrolone will improve pulmonary function in burned pediatric subjects. A subset of severely burned pediatric subjects from a prospective clinical trial (n = 222) were included in our study (n = 54, 7...
Source: Journal of Burn Care and Research - September 1, 2016 Category: Rehabilitation Tags: Original Articles Source Type: research
Guidelines for Burn Care Under Austere Conditions: Introduction to Burn Disaster, Airway and Ventilator Management, and Fluid Resuscitation
No abstract available (Source: Journal of Burn Care and Research)
Source: Journal of Burn Care and Research - September 1, 2016 Category: Rehabilitation Tags: Summary Articles Source Type: research
A Review of Monocytes and Monocyte-Derived Cells in Hypertrophic Scarring Post Burn
Pediatric burns remain a common injury after which many patients develop a severe form of scarring known as hypertrophic scarring. The formation of the hypertrophic scar arises from excessive production of collagen during wound healing. Wound repair and regeneration represents a complex process that is accomplished through many biological processes involving various cell types, extracellular matrix proteins, cytokines, and other mediators. One important cell type is the monocyte, which displays an altered profile in many wound models. These profile changes may function as biomarkers, reflecting and/or influencing the clini...
Source: Journal of Burn Care and Research - September 1, 2016 Category: Rehabilitation Tags: Summary Articles Source Type: research
Proceedings of the American Burn Association 48th Annual Meeting: Erratum
No abstract available (Source: Journal of Burn Care and Research)
Source: Journal of Burn Care and Research - July 1, 2016 Category: Rehabilitation Tags: Erratum Source Type: research
Improving and Maintaining Conformity of Acticoat® Dressings with Shear Reducing Transfixion Suture
No abstract available (Source: Journal of Burn Care and Research)
Source: Journal of Burn Care and Research - July 1, 2016 Category: Rehabilitation Tags: Letters to the Editor Source Type: research
Exposure to an Iridium-192 Source in an Industrial Safety Worker: Follow-Up Period Should be Longer
No abstract available (Source: Journal of Burn Care and Research)
Source: Journal of Burn Care and Research - July 1, 2016 Category: Rehabilitation Tags: Letters to the Editor Source Type: research
The Fire Challenge: Dare to Be Burned
No abstract available (Source: Journal of Burn Care and Research)
Source: Journal of Burn Care and Research - July 1, 2016 Category: Rehabilitation Tags: Letters to the Editor Source Type: research
Fostering Disaster Preparedness through the “Grass Roots Efforts” of an American Burn Association Special Interest Group
No abstract available (Source: Journal of Burn Care and Research)
Source: Journal of Burn Care and Research - July 1, 2016 Category: Rehabilitation Tags: Letters to the Editor Source Type: research
Dermabrasion and Thin Epidermal Grafting for Treatment of Large and Small Areas of Postburn Leukoderma: A Case Series and Review of the Literature
This study is unique in describing grafting on multiple occasions and for larger areas than previously described, with two patients undergoing grafting more than 200 cm2. (Source: Journal of Burn Care and Research)
Source: Journal of Burn Care and Research - July 1, 2016 Category: Rehabilitation Tags: Case Reports Source Type: research
Simultaneous Extended ALT Flaps for Foot Salvage After Severe Frostbite
Plantar area reconstruction represents the most challenging part of the lower limb. The anterolateral thigh (ALT) flap proved to be a versatile flap for this special area. Herein, we present the application of bilateral ALT free flaps for foot salvage after frostbite injury and long-term follow-up. Single perforator bilateral ALT flaps (304 and 320 cm2) were harvested and anastomosed to posterior tibial vessels. The lateral femoral cutaneous nerve was anastomosed to the calcaneal branches of the posterior tibial nerve. The two-point discrimination test showed values from 16 to 28 mm in different flap areas 5 years late...
Source: Journal of Burn Care and Research - July 1, 2016 Category: Rehabilitation Tags: Case Reports Source Type: research
Lipid Rescue in a Pediatric Burn Patient
Pain control is a major concern for patients suffering burns. The addition of bupivacaine to the donor site infiltration solution containing epinephrine could offer a safe and effective means to treat postanesthesia pain. Despite the addition of epinephrine to localize the effects, systemic absorption occurs, and there exists the possibility of inadvertent intravascular injection, with potential CNS and cardiac toxicity. The patient is a 6-year-old boy who sustained flame burns to bilateral lower extremities and buttocks. A Pitkin’s solution containing 2 mg epinephrine/L of normosol and a 0.5% bupivacaine at 3 mg/kg ...
Source: Journal of Burn Care and Research - July 1, 2016 Category: Rehabilitation Tags: Case Reports Source Type: research
Oxalate Nephropathy After Continuous Infusion of High-Dose Vitamin C as an Adjunct to Burn Resuscitation
Fluid resuscitation is the foundation of management in burn patients and is the topic of considerable research. One adjunct in burn resuscitation is continuous, high-dose vitamin C (ascorbic acid) infusion, which may reduce fluid requirements and thus decrease the risk for over resuscitation. Research in preclinical studies and clinical trials has shown continuous infusions of high-dose vitamin C to be beneficial with decrease in resuscitative volumes and limited adverse effects. However, high-dose and low-dose vitamin C supplementation has been shown to cause secondary calcium oxalate nephropathy, worsen acute kidney inju...
Source: Journal of Burn Care and Research - July 1, 2016 Category: Rehabilitation Tags: Case Reports Source Type: research
