Impact of Patient-Specific Inflow Velocity Profile on Hemodynamics of the Thoracic Aorta
Computational fluid dynamics (CFD) provides a noninvasive method to functionally assess aortic hemodynamics. The thoracic aorta has an anatomically complex inlet comprising of the aortic valve and root, which is highly prone to different morphologies and pathologies. We investigated the effect of using patient-specific (PS) inflow velocity profiles compared to idealized profiles based on the patient's flow waveform. A healthy 31 yo with a normally functioning tricuspid aortic valve (subject A), and a 52 yo with a bicuspid aortic valve (BAV), aortic valvular stenosis, and dilated ascending aorta (subject B) were studied. Su...
Source: Journal of Biomechanical Engineering - October 19, 2017 Category: Biomedical Engineering Source Type: research

Muscle Function and Coordination of Stair Ascent
Stair ascent is an activity of daily living and necessary for maintaining independence in community environments. One challenge to improving an individual's ability to ascend stairs is a limited understanding of how lower-limb muscles work in synergy to perform stair ascent. Through dynamic coupling, muscles can perform multiple functions and require contributions from other muscles to perform a task successfully. The purpose of this study was to identify the functional roles of individual muscles during stair ascent and the mechanisms by which muscles work together to perform specific subtasks. A three-dimensional (3D) mu...
Source: Journal of Biomechanical Engineering - October 19, 2017 Category: Biomedical Engineering Source Type: research

Modeling the Deformation of the Elastin Network in the Aortic Valve
This paper is concerned with proposing a suitable structurally motivated strain energy function, denoted by Weelastin  network, for modeling the deformation of the elastin network within the aortic valve (AV) tissue. The AV elastin network is the main noncollagenous load-bearing component of the valve matrix, and therefore, in the context of continuum-based modeling of the AV, the Weelastin network strain energ y function would essentially serve to model the contribution of the “isotropic matrix.” To date, such a function has mainly been considered as either a generic neo-Hookean term or a general exponential funct...
Source: Journal of Biomechanical Engineering - October 19, 2017 Category: Biomedical Engineering Source Type: research

A Finite Element Model of a Midsize Male for Simulating Pedestrian Accidents
Pedestrians represent one of the most vulnerable road users and comprise nearly 22% the road crash-related fatalities in the world. Therefore, protection of pedestrians in car-to-pedestrian collisions (CPC) has recently generated increased attention with regulations involving three subsystem tests. The development of a finite element (FE) pedestrian model could provide a complementary component that characterizes the whole-body response of vehicle –pedestrian interactions and assesses the pedestrian injuries. The main goal of this study was to develop and to validate a simplified full body FE model corresponding to a 50t...
Source: Journal of Biomechanical Engineering - October 19, 2017 Category: Biomedical Engineering Source Type: research

Impact of Patient-Specific Inflow Velocity Profile on Hemodynamics of the Thoracic Aorta
Computational fluid dynamics (CFD) provides a noninvasive method to functionally assess aortic hemodynamics. The thoracic aorta has an anatomically complex inlet comprising of the aortic valve and root, which is highly prone to different morphologies and pathologies. We investigated the effect of using patient-specific (PS) inflow velocity profiles compared to idealized profiles based on the patient's flow waveform. A healthy 31 yo with a normally functioning tricuspid aortic valve (subject A), and a 52 yo with a bicuspid aortic valve (BAV), aortic valvular stenosis, and dilated ascending aorta (subject B) were studied. Su...
Source: Journal of Biomechanical Engineering - October 19, 2017 Category: Biomedical Engineering Source Type: research