Cover
(Source: JNCI Monographs)
Source: JNCI Monographs - November 3, 2014 Category: Cancer & Oncology Tags: Cover / Standing Material Source Type: research
Etiologic Heterogeneity Among Non-Hodgkin Lymphoma Subtypes: The InterLymph Non-Hodgkin Lymphoma Subtypes Project
Conclusions
Using a novel approach to investigate etiologic heterogeneity among NHL subtypes, we identified risk factors that were common among subtypes as well as risk factors that appeared to be distinct among individual or a few subtypes, suggesting both subtype-specific and shared underlying mechanisms. Further research is needed to test putative mechanisms, investigate other risk factors (eg, other infections, environmental exposures, and diet), and evaluate potential joint effects with genetic susceptibility. (Source: JNCI Monographs)
Source: JNCI Monographs - August 30, 2014 Category: Cancer & Oncology Authors: Morton, L. M., Slager, S. L., Cerhan, J. R., Wang, S. S., Vajdic, C. M., Skibola, C. F., Bracci, P. M., de Sanjose, S., Smedby, K. E., Chiu, B. C. H., Zhang, Y., Mbulaiteye, S. M., Monnereau, A., Turner, J. J., Clavel, J., Adami, H.-O., Chang, E. T., Glim Tags: Article Source Type: research
Medical History, Lifestyle, Family History, and Occupational Risk Factors for Adult Acute Lymphocytic Leukemia: The InterLymph Non-Hodgkin Lymphoma Subtypes Project
Conclusions
The small number of statistically significant risk factors identified out of the 112 variables examined could be chance findings and will require further replication to assess their role in the etiology of adult ALL. (Source: JNCI Monographs)
Source: JNCI Monographs - August 30, 2014 Category: Cancer & Oncology Authors: Skibola, C. F., Slager, S. L., Berndt, S. I., Lightfoot, T., Sampson, J. N., Morton, L. M., Weisenburger, D. D. Tags: Article Source Type: research
Medical History, Lifestyle, and Occupational Risk Factors for Hairy Cell Leukemia: The InterLymph Non-Hodgkin Lymphoma Subtypes Project
Conclusions
Our observations of an increased risk of HCL from farming exposures and decreased risk from smoking exposures, independent of one another, support a multifactorial origin and an etiological specificity of HCL compared with other non-Hodgkin lymphoma subtypes. The positive association with height is a novel finding that needs replication. (Source: JNCI Monographs)
Source: JNCI Monographs - August 30, 2014 Category: Cancer & Oncology Authors: Monnereau, A., Slager, S. L., Hughes, A. M., Smith, A., Glimelius, B., Habermann, T. M., Berndt, S. I., Staines, A., Norman, A. D., Cerhan, J. R., Sampson, J. N., Morton, L. M., Clavel, J. Tags: Article Source Type: research
Medical History, Lifestyle, Family History, and Occupational Risk Factors for Sporadic Burkitt Lymphoma/Leukemia: The Interlymph Non-Hodgkin Lymphoma Subtypes Project
Conclusions
Our data suggest that BL in younger and older adults may be etiologically distinct. (Source: JNCI Monographs)
Source: JNCI Monographs - August 30, 2014 Category: Cancer & Oncology Authors: Mbulaiteye, S. M., Morton, L. M., Sampson, J. N., Chang, E. T., Costas, L., de Sanjose, S., Lightfoot, T., Kelly, J., Friedberg, J. W., Cozen, W., Marcos-Gragera, R., Slager, S. L., Birmann, B. M., Weisenburger, D. D. Tags: Article Source Type: research
Medical History, Lifestyle, Family History, and Occupational Risk Factors for Mycosis Fungoides and Sezary Syndrome: The InterLymph Non-Hodgkin Lymphoma Subtypes Project
Conclusions
Our study provided the first detailed analysis of risk factors for MF/SS and further investigation is needed to confirm these findings in prospective data and in other populations. (Source: JNCI Monographs)
Source: JNCI Monographs - August 30, 2014 Category: Cancer & Oncology Authors: Aschebrook-Kilfoy, B., Cocco, P., La Vecchia, C., Chang, E. T., Vajdic, C. M., Kadin, M. E., Spinelli, J. J., Morton, L. M., Kane, E. V., Sampson, J. N., Kasten, C., Feldman, A. L., Wang, S. S., Zhang, Y. Tags: Article Source Type: research
Medical History, Lifestyle, Family History, and Occupational Risk Factors for Lymphoplasmacytic Lymphoma/Waldenstrom's Macroglobulinemia: The InterLymph Non-Hodgkin Lymphoma Subtypes Project
Conclusions
This pooled analysis confirmed associations with immune conditions and family history of hematologic malignancy, and identified new associations with hay fever, weight, smoking, and occupation, and no association with other lifestyle factors. These findings offer clues to LPL/WM biology and prevention. (Source: JNCI Monographs)
Source: JNCI Monographs - August 30, 2014 Category: Cancer & Oncology Authors: Vajdic, C. M., Landgren, O., McMaster, M. L., Slager, S. L., Brooks-Wilson, A., Smith, A., Staines, A., Dogan, A., Ansell, S. M., Sampson, J. N., Morton, L. M., Linet, M. S. Tags: Article Source Type: research
Medical History, Lifestyle, Family History, and Occupational Risk Factors for Mantle Cell Lymphoma: The InterLymph Non-Hodgkin Lymphoma Subtypes Project
Conclusions
The novel observations of a possible role for atopy and allergy and farm life in risk of MCL, together with confirmatory evidence of a familial link, suggest a multifactorial etiology of immune-related environmental exposures and genetic susceptibility. These findings provide guidance for future research in MCL etiology. (Source: JNCI Monographs)
Source: JNCI Monographs - August 30, 2014 Category: Cancer & Oncology Authors: Smedby, K. E., Sampson, J. N., Turner, J. J., Slager, S. L., Maynadie, M., Roman, E., Habermann, T. M., Flowers, C. R., Berndt, S. I., Bracci, P. M., Hjalgrim, H., Weisenburger, D. D., Morton, L. M. Tags: Article Source Type: research
Medical History, Lifestyle, Family History, and Occupational Risk Factors for Peripheral T-Cell Lymphomas: The InterLymph Non-Hodgkin Lymphoma Subtypes Project
Conclusions Our pooled analyses identified a number of new potential risk factors for PTCL and require further validation in independent series. (Source: JNCI Monographs)
Source: JNCI Monographs - August 30, 2014 Category: Cancer & Oncology Authors: Wang, S. S., Flowers, C. R., Kadin, M. E., Chang, E. T., Hughes, A. M., Ansell, S. M., Feldman, A. L., Lightfoot, T., Boffetta, P., Melbye, M., Lan, Q., Sampson, J. N., Morton, L. M., Zhang, Y., Weisenburger, D. D. Tags: Article Source Type: research
Medical History, Lifestyle, Family History, and Occupational Risk Factors for Marginal Zone Lymphoma: The InterLymph Non-Hodgkin Lymphoma Subtypes Project
Conclusion
Our results provide new data suggesting etiologic heterogeneity across MZL subtypes although a common risk of MZL associated with B-cell activating autoimmune conditions was found. (Source: JNCI Monographs)
Source: JNCI Monographs - August 30, 2014 Category: Cancer & Oncology Authors: Bracci, P. M., Benavente, Y., Turner, J. J., Paltiel, O., Slager, S. L., Vajdic, C. M., Norman, A. D., Cerhan, J. R., Chiu, B. C. H., Becker, N., Cocco, P., Dogan, A., Nieters, A., Holly, E. A., Kane, E. V., Smedby, K. E., Maynadie, M., Spinelli, J. J., R Tags: Article Source Type: research
Medical History, Lifestyle, Family History, and Occupational Risk Factors for Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma: The InterLymph Non-Hodgkin Lymphoma Subtypes Project
Conclusions
We have identified or confirmed several independent risk factors for CLL/SLL supporting a role for genetics (through family history), immune function (through allergy and sun), infection (through hepatitis C virus), and height, and other pathways of immune response. Given that CLL/SLL has more than 30 susceptibility loci identified to date, studies evaluating the interaction among genetic and nongenetic factors are warranted. (Source: JNCI Monographs)
Source: JNCI Monographs - August 30, 2014 Category: Cancer & Oncology Authors: Slager, S. L., Benavente, Y., Blair, A., Vermeulen, R., Cerhan, J. R., Costantini, A. S., Monnereau, A., Nieters, A., Clavel, J., Call, T. G., Maynadie, M., Lan, Q., Clarke, C. A., Lightfoot, T., Norman, A. D., Sampson, J. N., Casabonne, D., Cocco, P., de Tags: Article Source Type: research
Medical History, Lifestyle, Family History, and Occupational Risk Factors for Follicular Lymphoma: The InterLymph Non-Hodgkin Lymphoma Subtypes Project
Conclusions
The few relationships observed provide clues suggesting a multifactorial etiology of FL but are limited in the extent to which they explain FL occurrence. (Source: JNCI Monographs)
Source: JNCI Monographs - August 30, 2014 Category: Cancer & Oncology Authors: Linet, M. S., Vajdic, C. M., Morton, L. M., de Roos, A. J., Skibola, C. F., Boffetta, P., Cerhan, J. R., Flowers, C. R., de Sanjose, S., Monnereau, A., Cocco, P., Kelly, J. L., Smith, A. G., Weisenburger, D. D., Clarke, C. A., Blair, A., Bernstein, L., Zh Tags: Article Source Type: research
Medical History, Lifestyle, Family History, and Occupational Risk Factors for Diffuse Large B-Cell Lymphoma: The InterLymph Non-Hodgkin Lymphoma Subtypes Project
Conclusion
Our results support a complex and multifactorial etiology for DLBCL with some variation in risk observed by sex and anatomical site. (Source: JNCI Monographs)
Source: JNCI Monographs - August 30, 2014 Category: Cancer & Oncology Authors: Cerhan, J. R., Kricker, A., Paltiel, O., Flowers, C. R., Wang, S. S., Monnereau, A., Blair, A., Maso, L. D., Kane, E. V., Nieters, A., Foran, J. M., Miligi, L., Clavel, J., Bernstein, L., Rothman, N., Slager, S. L., Sampson, J. N., Morton, L. M., Skibola, Tags: Article Source Type: research
Rationale and Design of the International Lymphoma Epidemiology Consortium (InterLymph) Non-Hodgkin Lymphoma Subtypes Project
Conclusions
The International Lymphoma Epidemiology Consortium NHL Subtypes Project provides the largest and most comprehensive investigation of potential risk factors for a broad range of common and rare NHL subtypes to date. The analyses contribute to our understanding of the multifactorial nature of NHL subtype etiologies, motivate hypothesis-driven prospective investigations, provide clues for prevention, and exemplify the benefits of international consortial collaboration in cancer epidemiology. (Source: JNCI Monographs)
Source: JNCI Monographs - August 30, 2014 Category: Cancer & Oncology Authors: Morton, L. M., Sampson, J. N., Cerhan, J. R., Turner, J. J., Vajdic, C. M., Wang, S. S., Smedby, K. E., de Sanjose, S., Monnereau, A., Benavente, Y., Bracci, P. M., Chiu, B. C. H., Skibola, C. F., Zhang, Y., Mbulaiteye, S. M., Spriggs, M., Robinson, D., N Tags: Article Source Type: research
Table of Contents
(Source: JNCI Monographs)
Source: JNCI Monographs - August 30, 2014 Category: Cancer & Oncology Tags: Cover / Standing Material Source Type: research
