Systemic bone marker expression induced by Gray and White Mineral Trioxide Aggregate in normal and diabetic conditions
ConclusionBoth MTA materials were associated with an increase in serum calcium, phosphorus and ALP, suggesting a potential systemic effect, along with triggered differentiation of OCN and OPN positive cells. Moreover, in diabetic conditions, an inhibitory effect on MTA‐induced differentiation of OCN and OPN positive cells was detected.This article is protected by copyright. All rights reserved. (Source: International Endodontic Journal)
Source: International Endodontic Journal - January 29, 2018 Category: Dentistry Authors: I O de Azevedo Queiroz, W G Mello, C M Martins, R Dal Fabbro, L G Narciso, L Massunari, L T A Cintra, E Ervolino, J E Gomes ‐Filho Tags: Original Scientific Article Source Type: research

Differences in root canal system configuration in human permanent teeth within different age groups
ConclusionClinicians should be aware that the root canal system configuration changes over a lifetime. In the present study, the most affected teeth were both second premolars and the distal root of the mandibular first molar.This article is protected by copyright. All rights reserved. (Source: International Endodontic Journal)
Source: International Endodontic Journal - January 24, 2018 Category: Dentistry Authors: J. N. R. Martins, R. Ordinola ‐Zapata, D. Marques, H. Francisco, J. Caramês Tags: Original Scientific Article Source Type: research

Effectiveness of supplementary irrigant agitation with the Finisher GF Brush on the debridement of oval root canals instrumented with the Gentlefile or nickel titanium rotary instruments
ConclusionsSupplementary irrigant agitation with the Finisher GF Brush improved debridement of canals prepared with Gentlefile and size 25, .04 taper rotary NiTi. Root canal debridement did not significantly differ between the instruments when syringe irrigation was used.This article is protected by copyright. All rights reserved. (Source: International Endodontic Journal)
Source: International Endodontic Journal - January 24, 2018 Category: Dentistry Authors: P. Neelakantan, K. Khan, K. Y. Li, H. Shetty, W. Xi Tags: Original Scientific Article Source Type: research

Efficacy of the ProTaper Retreatment system in removing Thermafil, GuttaCore or vertically compacted gutta ‐percha from curved root canals assessed by micro‐CT
ConclusionsRemaining filling material and dentine removal was similar for all canal filling techniques. Regaining working length was significantly faster for GuttaCore compared to Thermafil and vertically compacted gutta‐percha. Procedural errors occured during retreatment of severely curved root canals with the ProTaper Universal Retreatment files in 5 out of 60 canals (8%).This article is protected by copyright. All rights reserved. (Source: International Endodontic Journal)
Source: International Endodontic Journal - January 24, 2018 Category: Dentistry Authors: T. R ödig, J. Wagner, A. Wiegand, M. Rizk Tags: Original Scientific Article Source Type: research

A potential role for the silent information regulator 2 homologue 1 (SIRT1) in periapical periodontitis
ConclusionsThese findings suggest that SIRT1 may stimulate angiogenesis in periapical granulomas by triggering the proliferation of endothelial cells and inducing VEGF and VE‐cadherin expression.This article is protected by copyright. All rights reserved. (Source: International Endodontic Journal)
Source: International Endodontic Journal - January 24, 2018 Category: Dentistry Authors: H Kudo, O Takeichi, K Hatori, K Makino, K Himi, B Ogiso Tags: Original Scientific Article Source Type: research

Association between bacteria occurring in the apical canal system and expression of bone ‐resorbing mediators and matrix metalloproteinases in apical periodontitis
ConclusionActinobacteria may play an important role in the active phase of soft and bone tissue destruction in apical periodontitis.This article is protected by copyright. All rights reserved. (Source: International Endodontic Journal)
Source: International Endodontic Journal - January 24, 2018 Category: Dentistry Authors: A. Takahama, I. N. R ôças, I. S. P. Faustino, F. R. F. Alves, R. S. Azevedo, C. C. Gomes, W. R. Araújo‐Filho, J. F. Siqueira Tags: Original Scientific Article Source Type: research

Concentration ‐dependent effect of bleaching agents on the immunolabeling of interleukin‐6, interleukin‐17, and CD5‐positive cells in the dental pulp
ConclusionsIL‐6 and IL‐17 participated in inflammation in the pulp tissue of rats after dental bleaching, particularly at 2 days. The immunolabeling was greater with increasing H2O2 concentration. This process was accompanied by the prolonged activation of CD5‐positive cells.This article is protected by copyright. All rights reserved. (Source: International Endodontic Journal)
Source: International Endodontic Journal - January 21, 2018 Category: Dentistry Authors: F Benetti, J E Gomes ‐Filho, L L Ferreira, G Sivieri‐Araújo, E Ervolino, A L F Briso, L T A Cintra Tags: Original Scientific Article Source Type: research

Cytocompatibility of Biodentine and iRoot FS with human periodontal ligament cells: an in vitro study
ConclusionsiRoot FS had a positive effect on the adhesion, proliferation and biomineralization of hPDLCs compared with Biodentine.This article is protected by copyright. All rights reserved. (Source: International Endodontic Journal)
Source: International Endodontic Journal - January 19, 2018 Category: Dentistry Authors: T Luo, J Liu, Y Sun, Y Shen, L Zou Tags: Original Scientific Article Source Type: research

Impact of cone beam computed tomography on periapical assessment and treatment plan five to eleven years after surgical endodontic retreatment
ConclusionThe use of CBCT for long‐term follow‐up after SER may lead to more cases diagnosed with persisting or recurrent apical periodontitis and hence often to the recommendation of a more invasive treatment modality.This article is protected by copyright. All rights reserved. (Source: International Endodontic Journal)
Source: International Endodontic Journal - January 18, 2018 Category: Dentistry Authors: C Kruse, R Spin ‐Neto, A Wenzel, M Væth, L‐L Kirkevang Tags: Original Scientific Article Source Type: research

Antibiotic ‐prescribing for endodontic therapies: a comparative survey between general dental practitioners (GDPs) and final‐year Bachelor of Dental Surgery (BDS) students in Cardiff, UK
ConclusionFinal year undergraduate students were aware of the antibiotic resistance crisis, although a third were not aware of guidelines for use of antibiotics in endodontic conditions; their responses to clinical scenario were more compatible with the guidelines. General dentists were less aware of the implications of over‐use of antibiotics and the existence of guidelines, and their responses were occasionally incompatible with antibiotic‐guidelines for endodontic therapies.This article is protected by copyright. All rights reserved. (Source: International Endodontic Journal)
Source: International Endodontic Journal - January 10, 2018 Category: Dentistry Authors: AA Al Masan, P M H Dummer, D J J Farnell, M E Vianna Tags: Original Scientific Article Source Type: research

Levels of oxidative stress biomarkers and bone resorption regulators in apical periodontitis lesions infected by Epstein ‐Barr virus
ConclusionLevels of bone resorption regulators and oxidative stress biomarkers wereincreased in apical periodontitis compared to healthy pulp tissues. EBV positive periapical lesions exhibited higher levels of RANKL and OPG compared to EBV negative periapical lesions. EBV may contribute to progression of apical periodontitis via enhanced production of bone resorption regulators.This article is protected by copyright. All rights reserved. (Source: International Endodontic Journal)
Source: International Endodontic Journal - January 9, 2018 Category: Dentistry Authors: A. Jakovljevic, M Andric, N. Nikolic, V. Coric, S. Krezovic, J. Carkic, A. Knezevic, K Beljic ‐Ivanovic, M. Plješa‐Ercegovac, M. Miletić, I. Soldatovic, T. Radosavljevic, T. Jovanovic, T. Simic, V. Ivanovic, J. Milasin Tags: Original Scientific Article Source Type: research

Issue Information
(Source: International Endodontic Journal)
Source: International Endodontic Journal - January 5, 2018 Category: Dentistry Tags: Issue Information Source Type: research

Calcium chloride ‐enriched calcium aluminate cement promotes in vitro osteogenesis
International Endodontic Journal, EarlyView. (Source: International Endodontic Journal)
Source: International Endodontic Journal - January 2, 2018 Category: Dentistry Source Type: research

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International Endodontic Journal, Ahead of Print. (Source: International Endodontic Journal)
Source: International Endodontic Journal - January 2, 2018 Category: Dentistry Source Type: research