Infliximab Therapeutic Drug Monitoring Changes Clinical Decisions in a Virtual Biologics Clinic for Inflammatory Bowel Disease
Background:
Virtual biologics clinics are often used to review patients with inflammatory bowel disease receiving biological therapy, with decisions whether to continue, switch, or stop therapy made based on review of symptoms, disease history, and investigations. We aimed to investigate whether therapeutic drug monitoring of infliximab (IFX) trough levels and anti-drug antibodies influences decision making within a virtual biologics clinic.
Methods:
For all patients with inflammatory bowel disease receiving IFX maintenance therapy, 2 decisions were recorded in a preset format. The first decision was based on assessme...
Source: Inflammatory Bowel Diseases - November 29, 2017 Category: Gastroenterology Tags: IBD LIVE Articles Source Type: research
Dietary Polyphenols in the Aetiology of Crohn's Disease and Ulcerative Colitis—A Multicenter European Prospective Cohort Study (EPIC)
Conclusions:
The data supports a potential role of flavones and resveratrol in the risk of developing CD; future aetiological studies should investigate these dietary components and further examine the potential for residual confounding. (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - November 29, 2017 Category: Gastroenterology Tags: IBD LIVE Articles Source Type: research
Improving the Reproducibility and Quality of Reporting for Animal Studies in Inflammatory Bowel Disease
No abstract available (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - November 29, 2017 Category: Gastroenterology Tags: Editors' Commentary Source Type: research
IBD LIVE Series—Case 8: Treatment Options for Refractory Esophageal Crohn’s Disease and Hidradenitis Suppurativa: ERRATUM
No abstract available (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - November 1, 2017 Category: Gastroenterology Tags: Erratum Source Type: research
How to Avoid Primary Nonresponders to Infliximab in Crohn's Disease
No abstract available (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - November 1, 2017 Category: Gastroenterology Tags: Online Only: Letters to the Editor Source Type: research
Reply
No abstract available (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - November 1, 2017 Category: Gastroenterology Tags: Online Only: Letters to the Editor Source Type: research
Inflammatory Bowel Disease, the Hospital Anxiety and Depression Scale and Criterion Contamination
No abstract available (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - November 1, 2017 Category: Gastroenterology Tags: Online Only: Letters to the Editor Source Type: research
Cancer Risk in 2621 Chinese Patients with Inflammatory Bowel Disease: A Population-based Cohort Study
Conclusions: In a population-based study, Chinese patients with CD are at an increased risk of anorectal cancers and hematological cancers compared with the general population. A higher risk of nonmelanoma skin cancer was also observed in CD and UC. Cancer surveillance should be considered. (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - November 1, 2017 Category: Gastroenterology Tags: Original Clinical Articles Source Type: research
Efficacy of the Autoimmune Protocol Diet for Inflammatory Bowel Disease
Discussion: Dietary elimination can improve symptoms and endoscopic inflammation in patients with IBD. Randomized controlled trials are warranted. (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - November 1, 2017 Category: Gastroenterology Tags: Original Clinical Articles Source Type: research
Distinct Thresholds of Infliximab Trough Level Are Associated with Different Therapeutic Outcomes in Patients with Inflammatory Bowel Disease: A Prospective Observational Study
Background: Several studies have reported a strong correlation between infliximab (IFX) trough levels (trough levels of infliximab [TLI]) and clinical remission (CR). We aimed to determine threshold values of TLI associated with the occurrence of CR, with or without normal inflammatory biomarkers, including serum C-reactive protein (CRP) and fecal calprotectin (fCal).
Methods: We included prospectively all consecutive patients with inflammatory bowel disease under IFX therapy (5 mg/kg every 8 wk) for at least 6 months. Disease activity (using the Crohn's Disease Activity Index or Mayo score) was recorded, and TLI, CRP, an...
Source: Inflammatory Bowel Diseases - November 1, 2017 Category: Gastroenterology Tags: Original Clinical Articles Source Type: research
Incidence and Outcomes of Central Venous Catheter–related Blood Stream Infection in Patients with Inflammatory Bowel Disease in Routine Clinical Practice Setting
Conclusions: In this investigation, regardless of the patients' demographic features including immunosuppressive therapy, up to 30% of febrile IBD patients with CVC showed CRBSI. It is believed that CVC placement per se is a risk of CRBSI in patients with IBD. (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - November 1, 2017 Category: Gastroenterology Tags: Original Clinical Articles Source Type: research
Clinical Predictors and Natural History of Disease Extension in Patients with Ulcerative Proctitis
Background: A proportion of patients with initial presentation of ulcerative proctitis (UP) progress to more extensive colitis. We sought to characterize the natural history and identify clinical predictors of extension in UP.
Methods: We performed a retrospective cohort study of participants with a new diagnosis of UP from January 2000 to December 2015. We used Cox proportional hazard modeling to identify predictors of disease extension.
Results: We identified 169 new cases of UP with a median age of diagnosis of 40 years (range: 16–91 yr) and a median follow–up of 4.3 years (range: 3.3–15.1 yr). Fifty-three (31%)...
Source: Inflammatory Bowel Diseases - November 1, 2017 Category: Gastroenterology Tags: Original Clinical Articles Source Type: research
Fecal Calprotectin More Accurately Predicts Endoscopic Remission of Crohn's Disease than Serological Biomarkers Evaluated Using Balloon-assisted Enteroscopy
Conclusions: BAE findings showed that FC was more accurate for predicting endoscopic remission in CD than C-reactive protein, albumin, white blood cell count, and platelet count. Even in small-bowel CD, FC may be a more reliable surrogate marker of endoscopic remission than serological biomarkers. (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - November 1, 2017 Category: Gastroenterology Tags: Original Clinical Articles Source Type: research
Risk Factors and Clinical Outcomes in Patients with IBD with Melanoma
This study aims to (1) identify risk factors for melanoma development in patients with IBD, (2) compare clinical characteristics of melanoma in patients with IBD to the general population, and (3) assess the influence of immunosuppressive medication on survival.
Methods: We retrospectively searched the Dutch Pathology Database to identify all Dutch patients with IBD with cutaneous melanoma between January 1991 and December 2011. We then performed 2 case–control studies. To identify risk factors for melanoma development in IBD, we compared patients with IBD with melanoma to the general IBD population. To compare outcome ...
Source: Inflammatory Bowel Diseases - November 1, 2017 Category: Gastroenterology Tags: Original Clinical Articles Source Type: research
Optimizing Thiopurine Therapy in Inflammatory Bowel Disease Among 2 Real-life Intercept Cohorts: Effect of Allopurinol Comedication?
Background: Thiopurines (azathioprine and mercaptopurine) are frequently used immunosuppressive drugs to maintain remission in patients with inflammatory bowel disease. Half of the conventional thiopurine-derivative users have to discontinue treatment within 5 years, mainly because of intolerable adverse events. Over recent years, different strategies to optimize thiopurine treatment were suggested, yet, studies describing the clinical effectiveness of these strategies remain scarce. The aims of this study were to compare tolerability and sustained clinical benefit of conventional thiopurine derivatives therapy among two 5...
Source: Inflammatory Bowel Diseases - November 1, 2017 Category: Gastroenterology Tags: Original Clinical Articles Source Type: research
