Molecular targeted therapy with transarterial chemoembolization
Publication date: December 2013 Source:Gastrointestinal Intervention, Volume 2, Issue 2 Author(s): Su Jong Yu , Jung-Hwan Yoon Hepatocellular carcinoma (HCC) remains the third most common cause of cancer-related deaths worldwide, although improvements in patient stratification and the introduction of novel therapies have improved patient survival. Despite surveillance programs, 80% of HCCs are diagnosed at an advanced stage, at which point noncurative treatment, including transarterial chemoembolization (TACE) or sorafenib, is indicated. In intermediate stage HCC, suboptimal treatment outcomes are usually associated ...
Source: Gastrointestinal Intervention - November 1, 2014 Category: Gastroenterology Source Type: research
Submucosal injection solutions for endoscopic mucosal resection and endoscopic submucosal dissection of gastrointestinal neoplasms
Publication date: December 2013 Source:Gastrointestinal Intervention, Volume 2, Issue 2 Author(s): Yoon Suk Jung , Dong Il Park Endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD) are the standard treatment modalities for noninvasive gastrointestinal malignancies. To improve their efficacy and safety, endoscopic procedures require the formation of an adequate submucosal cushion, which is made between the lesion and the proper muscle layer. Ideal submucosal injection solutions should have the following characteristics: (1) they provide a long-lasting and high submucosal cushion, (2) are safe ...
Source: Gastrointestinal Intervention - November 1, 2014 Category: Gastroenterology Source Type: research
Temporary cecostomy as a life saving measure for functional obstruction secondary to neutropenic colitis
We describe a unique case of emergency percutaneous cecostomy for functional obstruction because of severe neutropenic colitis of the sigmoid colon. The cecum was fixed with four T-fasteners designed for gastropexy during radiological gastrostomy, and a large gastrostomy feeding tube was inserted. Drainage of fecal matter was difficult and intermittent; however, it allowed sufficient decompression of the bowel to prevent perforation until the neutropenic colitis resolved. In the absence of dedicated drainage systems for the bowel, standard gastrostomy kits can be used as an emergency measure in life-threatening large bowel...
Source: Gastrointestinal Intervention - November 1, 2014 Category: Gastroenterology Source Type: research
Chemoembolization via the right inferior phrenic artery in a patient with celiac stenosis: usefulness of angiography at full inspiration
Publication date: June 2014 Source:Gastrointestinal Intervention, Volume 3, Issue 1 Author(s): Leonard Sunwoo , Hyo-Cheol Kim , Roh-Eul Yoo , Jin Wook Chung The present report describes a case of successful chemoembolization via the right inferior phrenic artery (RIPA) in a patient with hepatocellular carcinoma and celiac stenosis due to the median arcuate ligament sling. The RIPA, which was not visualized on celiac angiography obtained at full expiration, was evidently visualized on angiography performed at full inspiration, followed by successful catheterization. Angiography at full inspiration can visualize and ...
Source: Gastrointestinal Intervention - November 1, 2014 Category: Gastroenterology Source Type: research
Percutaneous transhepatic portal vein stent-graft placement and jejunal varices embolization after hepaticojejunostomy
Publication date: June 2014 Source:Gastrointestinal Intervention, Volume 3, Issue 1 Author(s): Hee Ho Chu , Hyo-Cheol Kim , Saebeom Hur , Hwan Jun Jae , Jin Wook Chung Acquired portal vein (PV) stenosis or occlusion is most commonly seen after liver transplantation. In the nontransplant population, PV stenosis or occlusion can occur with pancreatitis, tumor encasement, and postsurgical complications. Portal hypertension resulting from PV stenosis or occlusion can cause variceal bleeding in the gastrointestinal tract. Bleeding from ectopic varices, such as duodenum, jejunum, ileum, and rectum, is rare and can be li...
Source: Gastrointestinal Intervention - November 1, 2014 Category: Gastroenterology Source Type: research
Endovascular management of pancreatitis related pseudoaneurysms – A single center experience
Conclusion Endovascular treatment is an effective first line of management in pancreatic pseudoaneurysms. The endovascular technique depends on the vascular location and morphological features of the pseudoaneurysm. (Source: Gastrointestinal Intervention)
Source: Gastrointestinal Intervention - November 1, 2014 Category: Gastroenterology Source Type: research
Role of endosonography in the management of incidental pancreatic cystic lesions
Publication date: June 2014 Source:Gastrointestinal Intervention, Volume 3, Issue 1 Author(s): Yu Man Ching Kelvin , Jin-Seok Park , Dong-Wan Seo The management of incidental pancreatic cystic lesion (PCL) can be challenging. With a better understanding of the natural course of PCL, we recommend surveillance of PCL without high-risk stigmata for at least 5 years. The importance of interventional endoscopic ultrasound (EUS) in establishing a specific diagnosis and treatment cannot be over-emphasized. This review aims to give an overview on the latest developments in EUS-guided fine needle aspiration and EUS-guided pa...
Source: Gastrointestinal Intervention - November 1, 2014 Category: Gastroenterology Source Type: research
Radiofrequency ablation for hepatocellular carcinoma
Publication date: June 2014 Source:Gastrointestinal Intervention, Volume 3, Issue 1 Author(s): Koichiro Yamakado , Haruyuki Takaki , Atsuhiro Nakatsuka , Takashi Yamaknaka , Masashi Fujimori , Takaaki Hasegawa , Junji Uraki Radiofrequency ablation (RFA) has changed the treatment strategy of hepatocellular carcinoma. Although RFA is usually applied for the treatment of small (≤3 cm) hepatocellular carcinomas, the combination with hepatic arterial chemoembolization has expanded the use of RFA to larger tumors. Refinements have lessened complications, leading to better prognosis even in the longer term. (Source:...
Source: Gastrointestinal Intervention - November 1, 2014 Category: Gastroenterology Source Type: research
Palliative enteroscopic stent placement for malignant mid-gut obstruction
Publication date: June 2014 Source:Gastrointestinal Intervention, Volume 3, Issue 1 Author(s): Esha Baichoo , Louis M. Wong Kee Song Palliation of malignant small intestinal obstructions beyond the reach of conventional endoscopes for stent placement generally requires endoscopic decompression via a gastrostomy tube or a surgical bypass in patients who are operable candidates. With the advent of deep enteroscopy, palliative stent placement for mid-gut obstruction using currently available self-expandable metal stents may be feasible in selected cases. Proper patient selection and technical proficiency in deep enteros...
Source: Gastrointestinal Intervention - November 1, 2014 Category: Gastroenterology Source Type: research
Endoscopic ultrasound-guided tumor ablation
Publication date: June 2014 Source:Gastrointestinal Intervention, Volume 3, Issue 1 Author(s): Alexander R. Ende , Joo Ha Hwang Endoscopic ultrasound (EUS)-guided interventions for treatment of periluminal tumors allows for a minimally invasive alternative to other more invasive methods of tumor therapies such as surgery or percutaneous ablation. For many tumors, especially pancreatic and peripancreatic tumors, EUS allows the most direct access for providing therapy. However, our experience with EUS-guided tumor ablation therapy remains limited. Several promising methods for EUS-guided ablation are in development or ...
Source: Gastrointestinal Intervention - November 1, 2014 Category: Gastroenterology Source Type: research
Endoscopic ultrasound-guided immunotherapy
Publication date: June 2014 Source:Gastrointestinal Intervention, Volume 3, Issue 1 Author(s): Atsushi Irisawa , Goro Shibukawa , Tadayuki Takagi , Yoko Abe , Akiko Saito , Koh Imbe , Koki Hoshi , Akane Yamabe , Ryo Igarashi Anti-tumoral endoscopic ultrasound-guided fine-needle injection (EUS-FNI), with its minimally invasive access for anti-tumoral agent delivery, is the most exciting field of intervention EUS. Pancreatic cancer is regarded as a systemic disease even if imaging modalities reveal no visible metastasis. From that perspective, immunological therapy is performed. To date, several reports have des...
Source: Gastrointestinal Intervention - November 1, 2014 Category: Gastroenterology Source Type: research
Endoscopic botulinum toxin injection: Benefit and limitation
Publication date: June 2014 Source:Gastrointestinal Intervention, Volume 3, Issue 1 Author(s): Chan Sup Shim Achalasia is an esophageal motility disorder of unknown cause that manifests as symptoms of difficulty in swallowing, with pooling of food and secretions in the lower esophagus. Endoscopic treatment for achalasia is directed at disrupting or weakening the lower esophageal sphincter (LES). As botulinum toxin (botox) is a potent inhibitor of acetylcholine release from nerve endings, it counteracts the unopposed LES contraction that is mediated by cholinergic nerves, thereby lowering LES pressure. In general, a to...
Source: Gastrointestinal Intervention - November 1, 2014 Category: Gastroenterology Source Type: research
Irreversible electroporation (NanoKnife) in cancer treatment
Publication date: June 2014 Source:Gastrointestinal Intervention, Volume 3, Issue 1 Author(s): Natanel Jourabchi , Kourosh Beroukhim , Bashir A. Tafti , Stephen T. Kee , Edward W. Lee Irreversible electroporation (IRE) is a promising new minimally invasive modality for the ablation of solid tumors. Unlike the current leading thermal ablation modalities, such as radiofrequency ablation (RFA) and cryoablation, IRE uses nonthermal electric energy to irreversibly destabilize cell membranes, resulting in focused cell death. Over the past 7 years, IRE has been emerging as a novel ablation tool by using the effect of an ...
Source: Gastrointestinal Intervention - November 1, 2014 Category: Gastroenterology Source Type: research
Early detection of early gastric cancer using image-enhanced endoscopy: Current trends
Publication date: June 2014 Source:Gastrointestinal Intervention, Volume 3, Issue 1 Author(s): Mingjun Song , Tiing Leong Ang Image-enhanced endoscopy refers to techniques of enhancing mucosa surface contrast with the ultimate aim of improving lesion detection and diagnosis. It is vital to detect early gastric cancer as it may be possible to perform curative endoscopic resection. In this topic review, we summarize the options available, such as the traditional dye-based chromoendoscopy, as well as the newer equipment-based techniques such as narrow-band imaging, flexible spectral imaging color enhancement, and i-scan...
Source: Gastrointestinal Intervention - November 1, 2014 Category: Gastroenterology Source Type: research
Photodynamic therapy in esophageal cancer
Publication date: Available online 16 September 2014 Source:Gastrointestinal Intervention Author(s): Richard A. Kozarek Historically, photodynamic therapy was an additional mechanism, along with external beam irradiation or brachytherapy, Nd:YAG laser tumor ablation or esophageal stent placement, and to a lesser extent, chemotherapy, used to reestablish esophageal continuity in patients with esophageal malignancy who could not undergo resective surgery by virtue of infirmity or tumor stage. However, it has been virtually abandoned for this indication by most practitioners for more than a decade. More recently, it has ...
Source: Gastrointestinal Intervention - November 1, 2014 Category: Gastroenterology Source Type: research
