Delayed auditory conduction in diabetes: is metformin-induced vitamin B12 deficiency responsible?
Authors: Khattar D, Khaliq F, Vaney N, Madhu SV
Abstract
The present study aims to evaluate the functional integrity of the auditory pathway in patients with diabetes taking metformin. A further aim is to assess its association with vitamin B12 deficiency induced by metformin. Thirty diabetics taking metformin and 30 age-matched non-diabetic controls were enrolled. Stimulus-related potentials and vitamin B12 levels were evaluated in all the subjects. The diabetics showed deficient vitamin B12 levels and delayed wave III latency and III-V interpeak latency in the right ear and delayed Na and Pa wave latenci...
Source: Functional Neurology - July 1, 2016 Category: Neurology Tags: Funct Neurol Source Type: research
Cerebrospinal fluid analysis after unprovoked first seizure.
This study is one of the few to evaluate postictal CSF parameters in a clinical setting, and to our knowledge the first to investigate these parameters specifically in the emergency department. The development of a rapid, easy-to-use test that does not require extensive laboratory equipment to differentiate UFS from other conditions could be of great value in everyday clinical practice.
PMID: 27358223 [PubMed - in process] (Source: Functional Neurology)
Source: Functional Neurology - July 1, 2016 Category: Neurology Tags: Funct Neurol Source Type: research
Outcomes of a multicomponent intervention on occupational performance in persons with unilateral acquired brain injury.
Authors: Huertas Hoyas E, Pedrero Pérez EJ, Águila Maturana AM, Rojo Mota G, Martínez Piédrola R, Pérez de Heredia Torres M
Abstract
Complications after unilateral acquired brain injury (ABI) can affect various areas of expertise causing (depending on the location of the lesion) impairment in occupational performance. The aim of this study was to analyze and compare the concepts of occupational performance and functional independence, both before and after a multicomponent intervention including occupational therapy, in persons with unilateral brain damage. This was a longitudinal quasi-experimental p...
Source: Functional Neurology - July 1, 2016 Category: Neurology Tags: Funct Neurol Source Type: research
Clinical effects of non-invasive cerebellar magnetic stimulation treatment combined with neuromotor rehabilitation in traumatic brain injury. A single case study.
We present the case of a 25-year-old man with chronic TBI (a bilateral corticosubcortical parieto-occipital lesion) who underwent three weeks of cerebellar intermittent theta burst stimulation (iTBS), a form of rTMS, combined with neurorehabilitation treatment. The Fugl-Meyer Assessment (FMA), Berg Balance Scale (BBS), Jebsen-Taylor Hand Function Test, and accelerometer gait analysis were administered before and after treatment. The results showed improvements in balance performance (BBS: T0=47; T1=53; +10.72%), motor recovery (FMA: T0=93/100; T1=96/100; +3.00%), step length (T0=50.4±7.2; T1=53.8±2.2 cm, p<0.001), and...
Source: Functional Neurology - July 1, 2016 Category: Neurology Tags: Funct Neurol Source Type: research
Delayed auditory conduction in diabetes: is metformin-induced vitamin B12 deficiency responsible?
Authors: Khattar D, Khaliq F, Vaney N, Madhu SV
Abstract
The present study aims to evaluate the functional integrity of the auditory pathway in patients with diabetes taking metformin. A further aim is to assess its association with vitamin B12 deficiency induced by metformin. Thirty diabetics taking metformin and 30 age-matched non-diabetic controls were enrolled. Stimulus-related potentials and vitamin B12 levels were evaluated in all the subjects. The diabetics showed deficient vitamin B12 levels and delayed wave III latency and III-V interpeak latency in the right ear and delayed Na and Pa wave latenci...
Source: Functional Neurology - June 10, 2016 Category: Neurology Tags: Funct Neurol Source Type: research
Vestibular disorders following different types of head and neck trauma.
Authors: Kolev OI, Sergeeva M
Abstract
This review focuses on the published literature on vestibular disorders following different types of head and neck trauma. Current knowledge of the different causes and underlying mechanisms of vestibular disorders, as well as the sites of organic damage, is presented. Non-organic mechanisms are also surveyed. The frequency of occurrence of vestibular symptoms, and of other accompanying subjective complaints, associated with different types of trauma is presented and related to the specific causes. Hypotheses about the pathogenesis of traumatic vestibular disorders ar...
Source: Functional Neurology - May 27, 2016 Category: Neurology Tags: Funct Neurol Source Type: research
Clinical effects of non-invasive cerebellar magnetic stimulation treatment combined with neuromotor rehabilitation in traumatic brain injury. A single case study.
We present the case of a 25-year-old man with chronic TBI (a bilateral corticosubcortical parieto-occipital lesion) who underwent three weeks of cerebellar intermittent theta burst stimulation (iTBS), a form of rTMS, combined with neurorehabilitation treatment. The Fugl-Meyer Assessment (FMA), Berg Balance Scale (BBS), Jebsen-Taylor Hand Function Test, and accelerometer gait analysis were administered before and after treatment. The results showed improvements in balance performance (BBS: T0=47; T1=53; +10.72%), motor recovery (FMA: T0=93/100; T1=96/100; +3.00%), step length (T0=50.4±7.2; T1=53.8±2.2 cm, p<0.001), and...
Source: Functional Neurology - May 27, 2016 Category: Neurology Tags: Funct Neurol Source Type: research
Cerebrospinal fluid analysis after unprovoked first seizure.
This study is one of the few to evaluate postictal CSF parameters in a clinical setting, and to our knowledge the first to investigate these parameters specifically in the emergency department. The development of a rapid, easy-to-use test that does not require extensive laboratory equipment to differentiate UFS from other conditions could be of great value in everyday clinical practice.
PMID: 27222259 [PubMed - as supplied by publisher] (Source: Functional Neurology)
Source: Functional Neurology - May 27, 2016 Category: Neurology Tags: Funct Neurol Source Type: research
Lower- and higher-level models of right hemisphere language. A selective survey.
Authors: Gainotti G
Abstract
The models advanced to explain right hemisphere (RH) language function can be divided into two main types. According to the older (lower-level) models, RH language reflects the ontogenesis of conceptual and semantic-lexical development; the more recent models, on the other hand, suggest that the RH plays an important role in the use of higher-level language functions, such as metaphors, to convey complex, abstract concepts. The hypothesis that the RH may be preferentially involved in processing the semantic-lexical components of language was advanced by Zaidel in splitbrain pat...
Source: Functional Neurology - May 16, 2016 Category: Neurology Tags: Funct Neurol Source Type: research
Antiepileptic drug use in a nursing home setting: a retrospective study in older adults.
Authors: Callegari C, Ielmini M, Bianchi L, Lucano M, Vender S
Abstract
The authors set out to examine qualitatively the use of antiepileptic drugs (AEDs) in a population of older adults in a nursing home setting, evaluating aspects such as specialist prescriptions and changes in dosage. This retrospective prevalence study was carried out in a state-funded nursing home that provides care and rehabilitation for elderly people. The first objective of the study was to determine the prevalence of AED use in this population. The second objective was to monitor AED dosage modifications during the fifteen-month s...
Source: Functional Neurology - May 16, 2016 Category: Neurology Tags: Funct Neurol Source Type: research
Reconstructing contralateral fiber tracts: methodological aspects of cerebello-thalamocortical pathway reconstruction.
Authors: Palesi F, Tournier JD, Calamante F, Muhlert N, Castellazzi G, Chard D, D'Angelo E, Wheeler-Kingshott CG
Abstract
The identification of pathways connecting the cerebral cortex with subcortical structures is critical to understanding how large-scale brain networks operate. The cerebellum, for example, is known to project numerous axonal bundles to thecerebral cortex passing through the thalamus. This paper focuses on the technical details of cerebello-thalamo-cortical pathway reconstruction using advanced diffusion MRI techniques in humans in vivo. Pathways reconstructed using seed/target placement ...
Source: Functional Neurology - May 6, 2016 Category: Neurology Tags: Funct Neurol Source Type: research
Outcomes of a multicomponent intervention on occupational performance in persons with unilateral acquired brain injury.
Authors: Huertas Hoyas E, Pedrero Pérez EJ, Águila Maturana AM, Rojo Mota G, Martínez Piédrola R, Pérez de Heredia Torres M
Abstract
Complications after unilateral acquired brain injury (ABI) can affect various areas of expertise causing (depending on the location of the lesion) impairment in occupational performance. The aim of this study was to analyze and compare the concepts of occupational performance and functional independence, both before and after a multicomponent intervention including occupational therapy, in persons with unilateral brain damage. This was a longitudinal quasi-experimental p...
Source: Functional Neurology - May 6, 2016 Category: Neurology Tags: Funct Neurol Source Type: research
Cerebral venous hemodynamic abnormalities in episodic and chronic migraine.
Authors: Petolicchio B, Viganò A, Di Biase A, Tatulli D, Toscano M, Vicenzini E, Passarelli F, Di Piero V
Abstract
Alterations of cerebral venous drainage have been demonstrated in chronic migraine (CM), suggesting that cerebral venous hemodynamic abnormalities (CVHAs) play a role in this condition. The aim of the present study was to look for a correlation between CM and CVHAs. We recruited 33 subjects suffering from CM with or without analgesic overuse, 29 episodic migraine (EM) patients with or without aura, and 21 healthy subjects as controls (HCs). CVHAs were evaluated by transcranial and extracrania...
Source: Functional Neurology - May 6, 2016 Category: Neurology Tags: Funct Neurol Source Type: research
Decision making in MS: factors affecting engagement in treatment choices.
Authors: Muhlert N
PMID: 27027888 [PubMed - in process] (Source: Functional Neurology)
Source: Functional Neurology - April 1, 2016 Category: Neurology Tags: Funct Neurol Source Type: research
Amyotrophic lateral sclerosis and environmental factors.
Authors: Bozzoni V, Pansarasa O, Diamanti L, Nosari G, Cereda C, Ceroni M
Abstract
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder that affects central and peripheral motor neuron cells. Its etiology is unknown, although a relationship between genetic background and environmental factors may play a major role in triggering the neurodegeneration. In this review, we analyze the role of environmental factors in ALS: heavy metals, electromagnetic fields and electric shocks, pesticides, β-N-methylamino-L-alanine, physical activity and the controversial role of sports. The literature o...
Source: Functional Neurology - April 1, 2016 Category: Neurology Tags: Funct Neurol Source Type: research
