FANCD2 protects genome stability by recruiting RNA processing enzymes to resolve R ‐loops during mild replication stress
This article is protected by copyright. All rights reserved. (Source: FEBS Journal)
Source: FEBS Journal - November 15, 2018 Category: Research Authors: Yusuke Okamoto,
Masako Abe,
Akiko Itaya,
Junya Tomida,
Masamichi Ishiai,
Akifumi Takaori ‐Kondo,
Masato Taoka,
Toshiaki Isobe,
Minoru Takata Tags: Original Article Source Type: research
Crystal Structures of VIM ‐1 Complexes Explain Active Site Heterogeneity in VIM‐Class Metallo‐β‐Lactamases
This article is protected by copyright. All rights reserved. (Source: FEBS Journal)
Source: FEBS Journal - November 15, 2018 Category: Research Authors: Ramya Salimraj,
Philip Hinchliffe,
Magda Kosmopoulou,
Jonathan M. Tyrrell,
J ürgen Brem,
Sander S. van Berkel,
Anil Verma,
Raymond J. Owens,
Michael A. McDonough,
Timothy R. Walsh,
Christopher J. Schofield,
James Spencer Tags: Original Article Source Type: research
Cooperativity in proton sensing by PIP aquaporins
This article is protected by copyright. All rights reserved. (Source: FEBS Journal)
Source: FEBS Journal - November 15, 2018 Category: Research Authors: Victoria Vitali,
Cintia Jozefkowicz,
Agustina Canessa Fortuna,
Gabriela Soto,
F. Luis Gonzalez Flecha,
Karina Alleva Tags: Original Article Source Type: research
Phosphomimetic ‐mediated in vitro rescue of hypertrophic cardiomyopathy linked to R58Q mutation in myosin regulatory light chain
This study focuses on the arginine to glutamine (R58Q) substitution in the human ventricular RLC (MYL2 gene), linked to malignant hypertrophic cardiomyopathy in humans and causing severe functional abnormalities in transgenic R58Q mice, inclu ding inhibition of cardiac RLC phosphorylation. Using a phosphomimic recombinant RLC variant where the phosphorylation site Ser‐15 was substituted with an aspartic acid (S15D) and placed in the background of R58Q, we aimed to assess whether we could rescue/mitigate R58Q‐induced structural/functi onal abnormalitiesin vitro. We show rescue of several R58Q ‐exerted adverse phenotyp...
Source: FEBS Journal - November 15, 2018 Category: Research Authors: Sunil Yadav,
Katarzyna Kazmierczak,
Jingsheng Liang,
Yoel H. Sitbon,
Danuta Szczesna ‐Cordary Tags: Original Article Source Type: research
Discovery and analysis of a novel ‐type serine biosynthetic enzyme, phosphoserine phosphatase in Thermus thermophilus
This article is protected by copyright. All rights reserved. (Source: FEBS Journal)
Source: FEBS Journal - November 15, 2018 Category: Research Authors: Yoko Chiba,
Ayako Yoshida,
Shigeru Shimamura,
Masafumi Kameya,
Takeo Tomita,
Makoto Nishiyama,
Ken Takai Tags: Original Article Source Type: research
FANCD2 protects genome stability by recruiting RNA processing enzymes to resolve R ‐loops during mild replication stress
This article is protected by copyright. All rights reserved. (Source: FEBS Journal)
Source: FEBS Journal - November 15, 2018 Category: Research Authors: Yusuke Okamoto,
Masako Abe,
Akiko Itaya,
Junya Tomida,
Masamichi Ishiai,
Akifumi Takaori ‐Kondo,
Masato Taoka,
Toshiaki Isobe,
Minoru Takata Tags: Original Article Source Type: research
Propeptide glycosylation and galectin ‐3 binding decrease proteolytic activation of human proMMP‐9/progelatinase B
In conclusion, modification of MMP‐9 propeptide glycosylation is a fine‐tuning mechanism and co‐determines the specific activity of MMP‐9 in physiology and p athology.This article is protected by copyright. All rights reserved. (Source: FEBS Journal)
Source: FEBS Journal - November 13, 2018 Category: Research Authors: Lise Boon,
Estefania Ugarte ‐Berzal,
Erik Martens,
Jennifer Vandooren,
Vasily Rybakin,
Didier Colau,
Monica Gordon‐Alonso,
Pierre van der Bruggen,
Walter Stöcker,
Christoph Becker‐Pauly,
Peter Witters,
Eva Morava‐Kozics,
Jaak Jaeken, Tags: Original Article Source Type: research
Structural basis for protein phosphatase 1 recruitment by glycogen ‐targeting subunits
This article is protected by copyright. All rights reserved. (Source: FEBS Journal)
Source: FEBS Journal - November 13, 2018 Category: Research Authors: Jun Yu,
Tingting Deng,
Song Xiang Tags: Original Article Source Type: research
Propeptide glycosylation and galectin ‐3 binding decrease proteolytic activation of human proMMP‐9/progelatinase B
In conclusion, modification of MMP‐9 propeptide glycosylation is a fine‐tuning mechanism and co‐determines the specific activity of MMP‐9 in physiology and p athology.This article is protected by copyright. All rights reserved. (Source: FEBS Journal)
Source: FEBS Journal - November 13, 2018 Category: Research Authors: Lise Boon,
Estefania Ugarte ‐Berzal,
Erik Martens,
Jennifer Vandooren,
Vasily Rybakin,
Didier Colau,
Monica Gordon‐Alonso,
Pierre van der Bruggen,
Walter Stöcker,
Christoph Becker‐Pauly,
Peter Witters,
Eva Morava‐Kozics,
Jaak Jaeken, Tags: Original Article Source Type: research
Structural basis for protein phosphatase 1 recruitment by glycogen ‐targeting subunits
This article is protected by copyright. All rights reserved. (Source: FEBS Journal)
Source: FEBS Journal - November 13, 2018 Category: Research Authors: Jun Yu,
Tingting Deng,
Song Xiang Tags: Original Article Source Type: research
The Molybdenum Storage Protein: A soluble ATP hydrolysis ‐dependent molybdate pump
Polyoxomolybdate cluster storage of the molybdenum storage protein is separated into a rapid ATP hydrolysis ‐dependent molybdate transport across the proteinous cage wall and a slow protein‐promoted and ATP‐independent molybdate self‐assembly process. Polyoxomolybdate clusters are formed in specific protein pockets supported by the high molybdate concentrations accumulated inside the cage provided via the molybdate pump. A continuous FeMo cofactor supply for nitrogenase maturation is ensured inAzotobacter vinelandii by developing a cage ‐like molybdenum storage protein (MoSto) capable to store ca. 120 molybdate m...
Source: FEBS Journal - November 12, 2018 Category: Research Authors: Juliane Poppe,
Steffen Br ünle,
Ron Hail,
Katharina Wiesemann,
Klaus Schneider,
Ulrich Ermler Tags: Original Article Source Type: research
Membrane topologies of PEX13 and PEX14 provide new insights on the mechanism of protein import into peroxisomes
This article is protected by copyright. All rights reserved. (Source: FEBS Journal)
Source: FEBS Journal - November 10, 2018 Category: Research Authors: Aurora Barros ‐Barbosa,
Maria J. Ferreira,
Tony A. Rodrigues,
Ana G. Pedrosa,
Cláudia P. Grou,
Manuel P. Pinto,
Marc Fransen,
Tânia Francisco,
Jorge E. Azevedo Tags: Original Article Source Type: research
nanoDSF as screening tool for enzyme libraries and biotechnology development
This article is protected by copyright. All rights reserved. (Source: FEBS Journal)
Source: FEBS Journal - November 10, 2018 Category: Research Authors: Anders O Magnusson,
Anna Szekrenyi,
Henk ‐Jan Joosten,
James Finnigan,
Simon Charnock,
Wolf‐Dieter Fessner Tags: Original Article Source Type: research
Membrane topologies of PEX13 and PEX14 provide new insights on the mechanism of protein import into peroxisomes
This article is protected by copyright. All rights reserved. (Source: FEBS Journal)
Source: FEBS Journal - November 10, 2018 Category: Research Authors: Aurora Barros ‐Barbosa,
Maria J. Ferreira,
Tony A. Rodrigues,
Ana G. Pedrosa,
Cláudia P. Grou,
Manuel P. Pinto,
Marc Fransen,
Tânia Francisco,
Jorge E. Azevedo Tags: Original Article Source Type: research
