Rituximab, cladribine and cyclophosphamide (RCC) induction with rituximab maintenance in chronic lymphocytic leukemia: PALG ‐ CLL4 (ML21283) trial
ConclusionsThe study confirmed the high efficacy and acceptable safety profile of induction therapy with RCC and maintenance therapy with rituximab in previously untreated patients with CLL.This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - February 1, 2018 Category: Hematology Authors: Tadeusz Robak, Jerzy Blonski, Aleksander Bart łomiej Skotnicki, Magdalena Piotrowska, Tomasz Wróbel, Justyna Rybka, Janusz Kłoczko, Łukasz Bołkun, Bożena Katarzyna Budziszewska, Urszula Walczak, Anatoly Uss, Marta Fidecka, Piotr Smolewski Tags: Original Article Source Type: research
The 2014 BCSH criteria and the 2016 WHO criteria for essential thrombocythemia: a comparison in a large ‐scale cohort
ConclusionThe BCSH criteria diagnosed ET in a broader range of patients encompassing a significant number of patients who would otherwise be diagnosed as prePMF or MPN‐u.This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - February 1, 2018 Category: Hematology Authors: Tomonori Ochiai, Hajime Yasuda, Marito Araki, Kyohei Misawa, Soji Morishita, Mai Nudejima, Yumi Hironaka, Shuichi Shirane, Yoko Edahiro, Akihiko Gotoh, Akimichi Ohsaka, Norio Komatsu Tags: Original Article Source Type: research
Rituximab in combination with chemotherapy for the treatment of chronic lymphocytic leukaemia in clinical practice
ConclusionChemoimmunotherapy with rituximab is feasible and safe in a wide variety of clinical settings in CLL, including the treatment of older patients with comorbidities (ClinicalTrials. gov NCT01178086).This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - February 1, 2018 Category: Hematology Authors: Marcel Reiser, Steffen D örfel, Manfred Hensel, Mark Hoesl, Wolf‐Oliver Jordan, Michael Koenigsmann, Dirk Meyer, Dietmar Reichert, Andreas Schwarzer, Moritz Marquardt, Kerstin Kellershohn, Kathleen Jentsch‐Ullrich Tags: Original Article Source Type: research
Chronic Lymphoproliferative Disorder of NK ‐cells: A Single‐Institution Review with Emphasis on Relative Utility of Multimodality Diagnostic Tools
ConclusionsPatients with CLPD‐NK have an indolent clinical course and frequent hematologic manifestations that are responsive to single‐agent therapy. Mutations in STAT3 are common and portend more pronounced clinical manifestations.This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - February 1, 2018 Category: Hematology Authors: Habibe Kurt, Jeffrey L. Jorgensen, Hesham M. Amin, Keyur P. Patel, Sa A. Wang, Pei Lin, Rashmi Kanagal ‐Shamanna, Sanam Loghavi, Beenu Thakral, Haitham A. Khogeer, Elias J. Jabbour, Shaoying Li, C. Cameron Yin, L. Jeffrey Medeiros, Joseph D. Khoury Tags: Original Article Source Type: research
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European Journal of Haematology, Ahead of Print. (Source: European Journal of Haematology)
Source: European Journal of Haematology - January 31, 2018 Category: Hematology Source Type: research
MLL ‐rearranged acute myeloid leukemia: Influence of the genetic partner in allo‐HSCT response and prognostic factor of MLL 3′ region mRNA expression
ConclusionWe show that the MLL genetic partner could have implications in allo‐HSCT response and we propose three genes whose expression could be useful for the prognosis of this leukemia in patients undergoing allo‐HSCT: 3′ region of MLL, EVI1 and FLT3.This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - January 31, 2018 Category: Hematology Authors: Sergio Burillo ‐Sanz, Rosario M Morales‐Camacho, Teresa Caballero‐Velázquez, Estrella Carrillo, Javier Sánchez, Olga Pérez‐López, Inmaculada Pérez de Soto, José González Campos, Concepción Prats‐Martín, Ricardo Bernal, M Teresa Vargas Tags: Original Article Source Type: research
MiRNA ‐15a, miRNA‐16, miRNA‐126, miRNA‐146a, miRNA‐223 expression in autologous hematopoietic stem cell transplantation and their impact on engraftment
ConclusionsIn conclusion, all investigated microRNAs changed significantly in the course of transplantation. Our results suggest that the miRNAs may participate in hematopoietic recovery in the early post‐transplant period and influence engraftment efficiency after HSCT.This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - January 30, 2018 Category: Hematology Authors: Mateusz Nowicki, Janusz Szemraj, Agnieszka Wierzbowska, Ma łgorzata Misiewicz, Roman Małachowski, Agnieszka Pluta, Olga Grzybowska–Izydorczyk, Tadeusz Robak, Anna Szmigielska‐Kapłon Tags: Original Article Source Type: research
Expression pattern of PD ‐L1 and PD‐L2 in classical Hodgkin lymphoma, primary mediastinal large B‐cell lymphoma, and gray zone lymphoma
ConclusionWe identified increased staining of PD‐L1 in cHL and that of PD‐L2 in PMBL. GZL had a pattern similar to that of cHL.This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - January 28, 2018 Category: Hematology Authors: Yosuke Tanaka, Akiko Miyagi Maeshima, Junko Nomoto, Shinichi Makita, Suguru Fukuhara, Wataru Munakata, Dai Maruyama, Kensei Tobinai, Yukio Kobayashi Tags: Original Article Source Type: research
Zebrafish larvae as a model to demonstrate secondary iron overload
ConclusionThis study presented a clear evidence of the effectiveness of zebrafish larvae to use as a tool to study iron overload and open the door for studying the efficiency of potential new iron chelating compounds other than commercially available ones.This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - January 27, 2018 Category: Hematology Authors: Gheyath K. Nasrallah, Nadin N. Younes, Missbah H. Baji, Amjad M. Shraim, Ibrahim Mustafa Tags: Original Article Source Type: research
Genetic variation in IL28B (IFNL3) and response to interferon ‐alpha treatment in myeloproliferative neoplasms
ConclusionThese results imply an effect of IL28B genotype on the outcome of IFN‐α treatment in MPN.This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - January 25, 2018 Category: Hematology Authors: Marie Lindgren, Jan Samuelsson, Lars Nilsson, H åvar Knutsen, Waleed Ghanima, Johan Westin, Peter L Johansson, Björn Andréasson Tags: Original Article Source Type: research
Pre ‐treatment with standard‐dose intravenous methylprednisolone does not improve outcomes in newly diagnosed immune thrombocytopenia (ITP)
ConclusionsInitiating methylprednisolone at a conventional dose provided no significant benefit compared to giving oral prednisone only to adults with ITP.This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - January 23, 2018 Category: Hematology Authors: Ana ïs Essilini, Thibault Comont, Johanne Germain, Natacha Brun, Claire Dingremont, Brice Castel, Sophie Arista, Serge Madaule, Laurent Sailler, Maryse Lapeyre‐Mestre, Odile Beyne‐rauzy, Bertrand Godeau, Daniel Adoue, Guillaume Moulis, Tags: Original Article Source Type: research
Risk ‐adapted GVHD prophylaxis with post‐transplantation cyclophosphamide in adults after related, unrelated and haploidentical transplantations
ConclusionThe suggested risk‐adapted PTCy‐based prophylaxis is feasible and is associated with low GVHD incidence and mortality in all types of grafts. The study was registered on clinicaltrials. gov (NCT02294552).This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - January 23, 2018 Category: Hematology Authors: Ivan S. Moiseev, Olga V. Pirogova, Alexandr L. Alyanski, Elena V. Babenko, Tatyana L. Gindina, Elena I. Darskaya, Olga A. Slesarchuk, Tatyana A. Bykova, Alexei B. Chukhlovin, Dmitrii E. Pevtcov, Sergey N. Bondarenko, Boris V. Afanasyev Tags: Original Article Source Type: research
Low plasma protein Z levels are associated with an increased risk for perioperative bleedings
ConclusionsLow PZ appears to be an underestimated risk factor for perioperative bleeding. Determination of PZ plasma concentrations might be useful in the preoperative workup in patients with a bleeding history, when detailed clotting analyses remains inconclusive.This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - January 23, 2018 Category: Hematology Authors: Clemens Hinterleitner, Klaus ‐Peter Kreisselmeier, Ann‐Christin Pecher, Paul‐Stefan Mauz, Lothar Kanz, Hans‐Georg Kopp, Karl G. Jaschonek Tags: Original Article Source Type: research
Issue Information
(Source: European Journal of Haematology)
Source: European Journal of Haematology - January 22, 2018 Category: Hematology Tags: ISSUE INFORMATION Source Type: research
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European Journal of Haematology, Ahead of Print. (Source: European Journal of Haematology)
Source: European Journal of Haematology - January 17, 2018 Category: Hematology Source Type: research
