Bacterial neuraminidase ‐mediated erythrocyte desialylation provokes cell surface aminophospholipid exposure
ConclusionCollectively, our data reveal that alteration of erythrocyte sialylation status by bacterial neuraminidase favors eryptotic cell death, an effect potentially contributing to reduced erythrocyte lifespan and anemia in sepsis.This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - February 17, 2018 Category: Hematology Authors: Syed M. Qadri, David A. Donkor, Ishac Nazy, Donald R. Branch, William P. Sheffield Tags: Original Article Source Type: research
Daratumumab resistance is frequent in advanced stage multiple myeloma patients irrespectively of CD38 expression, and is related to dismal prognosis
ConclusionsResponses to daratumumab and combinations in patients with advanced MM, particularly with extramedullary disease, are low and short lived, stressing the administration of this agent should be early in the course of the disease.This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - February 17, 2018 Category: Hematology Authors: M Pick, V Vainstein, N Goldschmidt, D Lavie, D Libster, A Gural, S Grisariu, B Avni, D Ben Yehuda, M.E Gatt Tags: Original Article Source Type: research
Issue Information
(Source: European Journal of Haematology)
Source: European Journal of Haematology - February 15, 2018 Category: Hematology Tags: ISSUE INFORMATION Source Type: research
Healthcare resource utilisation associated with skeletal ‐related events in European patients with multiple myeloma: results from a prospective, multinational, observational study
ConclusionsAll SREs were associated with substantial HRU; therefore, preventing SREs in MM will reduce the economic and resource burden on healthcare systems.This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - February 14, 2018 Category: Hematology Authors: John Ashcroft, Ignacio Duran, Herbert Hoefeler, Vito Lorusso, Diana Lueftner, Marco Campioni, Michele Intorcia, Amit Bahl Tags: Original Article Source Type: research
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European Journal of Haematology, Ahead of Print. (Source: European Journal of Haematology)
Source: European Journal of Haematology - February 9, 2018 Category: Hematology Source Type: research
Disease and treatment characteristics of polycythemia vera patients in Belgium: Results from a scientific survey
ConclusionThis survey provides better insight into the characteristics of Belgian PV patients and currently used treatment strategies. It shows that 232 (67.6%) PV patients continue to receive HU despite being potentially HU‐resistant. (Source: European Journal of Haematology)
Source: European Journal of Haematology - February 7, 2018 Category: Hematology Authors: Timothy Devos, Yves Beguin, Lucien Noens, Koen Eygen, Pierre Zach ée, Philippe Mineur, Laurent Knoops, Chantal Doyen, Koen Theunissen, Fleur Samantha Benghiat, Michael Reusens, Wim Pluymers Tags: ORIGINAL ARTICLE Source Type: research
Omitting cytogenetic assessment from routine treatment response monitoring in chronic myeloid leukemia is safe
ConclusionWe conclude that it is safe to omit routine cytogenetics for response assessment during treatment and to only use molecular monitoring, in order to prevent ambiguous classifications, reduce costs, and reduce the need for invasive bone marrow sampling. Cytogenetic re‐assessment should still be performed when molecular response is suboptimal. (Source: European Journal of Haematology)
Source: European Journal of Haematology - February 7, 2018 Category: Hematology Authors: Inge G.P. Geelen, Noortje Thielen, Jeroen J.W.M. Janssen, Mels Hoogendoorn, Tanja J.A. Roosma, Peter J.M. Valk, Otto Visser, Jan J. Cornelissen, Peter E. Westerweel Tags: ORIGINAL ARTICLE Source Type: research
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European Journal of Haematology, Ahead of Print. (Source: European Journal of Haematology)
Source: European Journal of Haematology - February 6, 2018 Category: Hematology Source Type: research
Systematic review of infectious events with the Bruton tyrosine kinase inhibitor ibrutinib in the treatment of hematologic malignancies
ConclusionsIbrutinib use requires prudent consideration of the impacts on host immunity. We identified a high rate of serious adverse infectious events within prospective clinical trials. Data suggest a role of both BTK and ITK inhibition for the increased events. There was considerable variability in the reporting of adverse events between trials, journals, and conference reports. (Source: European Journal of Haematology)
Source: European Journal of Haematology - February 6, 2018 Category: Hematology Authors: Benjamin F. Tillman, James M. Pauff, Gowri Satyanarayana, Mahsa Talbott, Jeremy L. Warner Tags: REVIEW ARTICLE Source Type: research
Efficacy, safety and cost of pomalidomide in relapsed and refractory multiple myeloma
ConclusionsThe study demonstrated that pomalidomide‐dexamethasone regimen has a long‐term favorable safety‐efficacy profile in RRMM patients. The survival benefit is substantial even in patients with stable disease.This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - February 2, 2018 Category: Hematology Authors: Pauline Gueneau, Marie ‐Lorraine Chretien, Amelie Cansac‐Miet, Ludwig Aho, Ingrid Lafon, Camille Favennec, Julien Guy, Denis Caillot, Mathieu Boulin Tags: Original Article Source Type: research
Safety of Direct Oral Anticoagulants versus Warfarin in Patients with Chronic Liver Disease and Atrial Fibrillation
ConclusionNo significant differences in bleeding rates were noted in patients treated with warfarin and DOAC agents. Further studies evaluating DOAC agents are needed to better understand the optimal anticoagulation strategy in setting of CLD.This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - February 1, 2018 Category: Hematology Authors: Pavel Goriacko, Keith T. Veltri Tags: Original Article Source Type: research
Thromboembolism prophylaxis in patients with Philadelphia ‐negative myeloproliferative neoplasms ‐ clinical practice among Nordic specialists
ConclusionsThe results of this study highlight the importance of considering all risk factors for thrombosis and an optimal collaboration with the primary health care sector.This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - February 1, 2018 Category: Hematology Authors: O. W. Bjerrum, J. Samuelsson, W. Ghanima, M. Kauppila, C. L. Andersen, Tags: Original Article Source Type: research
