Nrf2/HO-1 mediates the neuroprotective effects of pramipexole by attenuating oxidative damage and mitochondrial perturbation after traumatic brain injury in rats [RESEARCH ARTICLE]
This article has an associated First Person interview with the first author of the paper. (Source: DMM Disease Models and Mechanisms)
Source: DMM Disease Models and Mechanisms - August 18, 2020 Category: Biomedical Science Authors: Salman, M., Tabassum, H., Parvez, S. Tags: Rat as a Disease Model RESEARCH ARTICLE Source Type: research
The transcription factor Maz is essential for normal eye development [RESEARCH ARTICLE]
ABSTRACT
Wnt/β-catenin signaling has an essential role in eye development. Faulty regulation of this pathway results in ocular malformations, owing to defects in cell-fate determination and differentiation. Herein, we show that disruption of Maz, the gene encoding Myc-associated zinc-finger transcription factor, produces developmental eye defects in mice and humans. Expression of key genes involved in the Wnt cascade, Sfrp2, Wnt2b and Fzd4, was significantly increased in mice with targeted inactivation of Maz, resulting in abnormal peripheral eye formation with reduced proliferation of the progenitor cells in the regi...
Source: DMM Disease Models and Mechanisms - August 17, 2020 Category: Biomedical Science Authors: Medina-Martinez, O., Haller, M., Rosenfeld, J. A., O'Neill, M. A., Lamb, D. J., Jamrich, M. Tags: Developmental Disorders RESEARCH ARTICLE Source Type: research
DMM Outstanding Paper Prize 2019 winner: Alessandro Bailetti [EDITORIAL]
ABSTRACT
Disease Models & Mechanisms (DMM) is delighted to announce (with apologies for the delay) that the winner of the DMM Prize 2019 is Alessandro Bailetti, for his paper entitled ‘Enhancer of Polycomb and the Tip60 complex repress hematological tumor initiation by negatively regulating JAK/STAT pathway activity’ ( Bailetti et al., 2019). The prize of $1000 is awarded to the first author of the paper that is judged by the journal's editors to be the most outstanding contribution to the journal that year. To be considered for the prize, the first author must be a student or a postdoc of no more than 5&nb...
Source: DMM Disease Models and Mechanisms - August 13, 2020 Category: Biomedical Science Authors: Hackett, R. Tags: EDITORIAL Source Type: research
Systemic and heart autonomous effects of sphingosine {Delta}4 desaturase deficiency in lipotoxic cardiac pathophysiology [RESEARCH ARTICLE]
ABSTRACT
Lipotoxic cardiomyopathy (LCM) is characterized by cardiac steatosis, including the accumulation of fatty acids, triglycerides and ceramides. Model systems have shown the inhibition of ceramide biosynthesis to antagonize obesity and improve insulin sensitivity. Sphingosine 4 desaturase (encoded by ifc in Drosophila melanogaster) enzymatically converts dihydroceramide into ceramide. Here, we examine ifc mutants to study the effects of desaturase deficiency on cardiac function in Drosophila. Interestingly, ifc mutants exhibited classic hallmarks of LCM: cardiac chamber dilation, contractile defects and loss of fract...
Source: DMM Disease Models and Mechanisms - August 13, 2020 Category: Biomedical Science Authors: Walls, S. M., Chatfield, D. A., Ocorr, K., Harris, G. L., Bodmer, R. Tags: Drosophila as a Disease Model RESEARCH ARTICLE Source Type: research
First person - Laura Tamberg [FIRST PERSON]
ABSTRACT
First Person is a series of interviews with the first authors of a selection of papers published in Disease Models & Mechanisms, helping early-career researchers promote themselves alongside their papers. Laura Tamberg is first author on ‘Daughterless, the Drosophila orthologue of TCF4, is required for associative learning and maintenance of the synaptic proteome’, published in DMM. Laura is a PhD student in the lab of Tõnis Timmusk at the Tallinn University of Technology, Tallinn, Estonia. Her research involves investigating the use of Drosophila melanogaster as a model system to understand...
Source: DMM Disease Models and Mechanisms - July 29, 2020 Category: Biomedical Science Tags: FIRST PERSON Source Type: research
First person - Jenny Vermeer and Jonathan lent [FIRST PERSON]
ABSTRACT
First Person is a series of interviews with the first authors of a selection of papers published in Disease Models & Mechanisms, helping early-career researchers promote themselves alongside their papers. Jenny Vermeer and Jonathan lent are co-first authors on ‘A lineage-tracing tool to map the fate of hypoxic tumour cells’, published in DMM. Jenny conducted the research described in this article while a postdoctoral researcher in the lab of Ruth Muschel at the University of Oxford, Oxford, UK. She is now a project leader in the lab of Miranda van der Lee at Byondis, Nijmegen, The Netherlands, inve...
Source: DMM Disease Models and Mechanisms - July 29, 2020 Category: Biomedical Science Tags: FIRST PERSON Source Type: research
A lineage-tracing tool to map the fate of hypoxic tumour cells [RESEARCH ARTICLE]
This article has an associated First Person interview with the joint first authors of the paper. (Source: DMM Disease Models and Mechanisms)
Source: DMM Disease Models and Mechanisms - July 29, 2020 Category: Biomedical Science Authors: Vermeer, J. A. F., Ient, J., Markelc, B., Kaeppler, J., Barbeau, L. M. O., Groot, A. J., Muschel, R. J., Vooijs, M. A. Tags: Cancer metabolism RESEARCH ARTICLE Source Type: research
Ciliogenesis and Hedgehog signalling are suppressed downstream of KRAS during acinar-ductal metaplasia in mouse [RESEARCH ARTICLE]
ABSTRACT
Pancreatic ductal adenocarcinoma (PDAC) is the third leading cause of cancer-related deaths worldwide, but has a 5-year survival rate of only 7% primarily due to late diagnosis and ineffective therapies. To treat or even prevent PDAC, it is vital that we understand the initiating events that lead to tumour onset. PDAC develops from preneoplastic lesions, most commonly pancreatic intraepithelial neoplasias (PanINs), driven by constitutive activation of KRAS. In patients, PanINs are associated with regions of acinar-to-ductal metaplasia (ADM) where, in response to inflammation, acini dedifferentiate to a pancreatic ...
Source: DMM Disease Models and Mechanisms - July 29, 2020 Category: Biomedical Science Authors: Bangs, F. K., Miller, P., O'Neill, E. Tags: Cancer RESEARCH ARTICLE Source Type: research
Early evidence of delayed oligodendrocyte maturation in the mouse model of mucolipidosis type IV [RESEARCH ARTICLE]
ABSTRACT
Mucolipidosis type IV (MLIV) is a lysosomal disease caused by mutations in the MCOLN1 gene that encodes the endolysosomal transient receptor potential channel mucolipin-1, or TRPML1. MLIV results in developmental delay, motor and cognitive impairments, and vision loss. Brain abnormalities include thinning and malformation of the corpus callosum, white-matter abnormalities, accumulation of undegraded intracellular ‘storage’ material and cerebellar atrophy in older patients. Identification of the early events in the MLIV course is key to understanding the disease and deploying therapies. The Mcoln1&ndash...
Source: DMM Disease Models and Mechanisms - July 29, 2020 Category: Biomedical Science Authors: Mepyans, M., Andrzejczuk, L., Sosa, J., Smith, S., Herron, S., DeRosa, S., Slaugenhaupt, S. A., Misko, A., Grishchuk, Y., Kiselyov, K. Tags: Neurodegenerative disorders RESEARCH ARTICLE Source Type: research
Daughterless, the Drosophila orthologue of TCF4, is required for associative learning and maintenance of the synaptic proteome [RESEARCH ARTICLE]
This article has an associated First Person interview with the first author of the paper. (Source: DMM Disease Models and Mechanisms)
Source: DMM Disease Models and Mechanisms - July 29, 2020 Category: Biomedical Science Authors: Tamberg, L., Jaago, M., Säälik, K., Sirp, A., Tuvikene, J., Shubina, A., Kiir, C. S., Nurm, K., Sepp, M., Timmusk, T., Palgi, M. Tags: Developmental Disorders, Drosophila as a Disease Model RESEARCH ARTICLE Source Type: research
Rabbit model of Staphylococcus aureus implant-associated spinal infection [RESOURCE ARTICLE]
ABSTRACT
Post-surgical implant-associated spinal infection is a devastating complication commonly caused by Staphylococcus aureus. Biofilm formation is thought to reduce penetration of antibiotics and immune cells, contributing to chronic and difficult-to-treat infections. A rabbit model of a posterior-approach spinal surgery was created, in which bilateral titanium pedicle screws were interconnected by a plate at the level of lumbar vertebra L6 and inoculated with a methicillin-resistant S. aureus (MRSA) bioluminescent strain. In vivo whole-animal bioluminescence imaging (BLI) and ex vivo bacterial cultures demonstrated a...
Source: DMM Disease Models and Mechanisms - July 27, 2020 Category: Biomedical Science Authors: Gordon, O., Miller, R. J., Thompson, J. M., Ordonez, A. A., Klunk, M. H., Dikeman, D. A., Joyce, D. P., Ruiz-Bedoya, C. A., Miller, L. S., Jain, S. K. Tags: RESOURCE ARTICLE Source Type: research
Mitochondrial damage and senescence phenotype of cells derived from a novel frataxin G127V point mutation mouse model of Friedreich's ataxia [RESEARCH ARTICLE]
ABSTRACT
Friedreich's ataxia (FRDA) is an autosomal recessive neurodegenerative disease caused by reduced expression of the mitochondrial protein frataxin (FXN). Most FRDA patients are homozygous for large expansions of GAA repeat sequences in intron 1 of FXN, whereas a fraction of patients are compound heterozygotes, with a missense or nonsense mutation in one FXN allele and expanded GAAs in the other. A prevalent missense mutation among FRDA patients changes a glycine at position 130 to valine (G130V). Herein, we report generation of the first mouse model harboring an Fxn point mutation. Changing the evolutiona...
Source: DMM Disease Models and Mechanisms - July 26, 2020 Category: Biomedical Science Authors: Fil, D., Chacko, B. K., Conley, R., Ouyang, X., Zhang, J., Darley-Usmar, V. M., Zuberi, A. R., Lutz, C. M., Napierala, M., Napierala, J. S. Tags: Neurodegenerative disorders RESEARCH ARTICLE Source Type: research
First person - Anjali Bajpai [FIRST PERSON]
ABSTRACT
First Person is a series of interviews with the first authors of a selection of papers published in Disease Models & Mechanisms, helping early-career researchers promote themselves alongside their papers. Anjali Bajpai is first author on ‘A Drosophila model of oral peptide therapeutics for adult intestinal stem cell tumors’, published in DMM. Anjali is a Wellcome Trust DBT India Alliance early-career fellow in the lab of Prof. Pradip Sinha at Indian Institute of Technology, Kanpur, India, investigating the developmental principles that govern carcinogenesis using Drosophila as a model system. (Sour...
Source: DMM Disease Models and Mechanisms - July 22, 2020 Category: Biomedical Science Tags: FIRST PERSON Source Type: research
A Drosophila model of oral peptide therapeutics for adult intestinal stem cell tumors [RESEARCH ARTICLE]
This article has an associated First Person interview with the first author of the paper. (Source: DMM Disease Models and Mechanisms)
Source: DMM Disease Models and Mechanisms - July 22, 2020 Category: Biomedical Science Authors: Bajpai, A., Quazi, T. A., Tang, H.-W., Manzar, N., Singh, V., Thakur, A., Ateeq, B., Perrimon, N., Sinha, P. Tags: Cancer, Drosophila as a Disease Model RESEARCH ARTICLE Source Type: research
Temporal patterning in neural progenitors: from Drosophila development to childhood cancers [REVIEW]
ABSTRACT
The developing central nervous system (CNS) is particularly prone to malignant transformation, but the underlying mechanisms remain unresolved. However, periods of tumor susceptibility appear to correlate with windows of increased proliferation, which are often observed during embryonic and fetal stages and reflect stereotypical changes in the proliferative properties of neural progenitors. The temporal mechanisms underlying these proliferation patterns are still unclear in mammals. In Drosophila, two decades of work have revealed a network of sequentially expressed transcription factors and RNA-binding proteins t...
Source: DMM Disease Models and Mechanisms - July 21, 2020 Category: Biomedical Science Authors: Maurange, C. Tags: Cancer, Developmental Disorders, Drosophila as a Disease Model REVIEW Source Type: research
