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Precision medicine in ALK rearranged NSCLC: A rapidly evolving scenario
(Source: Critical Reviews in Oncology Hematology)
Source: Critical Reviews in Oncology Hematology - December 30, 2017 Category: Cancer & Oncology Authors: Addeo Alfredo, Tabb ò Fabrizio, Robinson Tim, Buffoni Lucio, Novello Silvia Source Type: research

Melatonin and breast cancer: evidences from preclinical and human studies
The breast cancer affects women with high mortality and morbidity worldwide. The risk is highest in the most developed world but also is markedly rising in the developing countries. It is well documented that melatonin has a significant anti-tumor activities demonstrated on various cancer types in a plethora of preclinical studies. In breast cancer, melatonin is capable to disrupt estrogen-dependent cell signaling, resulting in a reduction of estrogen-stimulated cells, moreover, it ’s obvious neuro-immunomodulatory effect in organism was described. (Source: Critical Reviews in Oncology Hematology)
Source: Critical Reviews in Oncology Hematology - December 29, 2017 Category: Cancer & Oncology Authors: Peter Kubatka, Pavol Zubor, Dietrich B üsselberg, Taeg Kyu Kwon, Mariusz Adamek, Daniel Petrovic, Radka Opatrilova, Katarina Gazdikova, Martin Caprnda, Luis Rodrigo, Jan Danko, Peter Kruzliak Source Type: research

The Role of Human Papillomavirus Vaccines in Cervical Cancer: Prevention and Treatment
Human papillomavirus (HPV) is the most common sexually transmitted disease, worldwide. Primary prevention thorough vaccination si able to reduce the burden of HPV-related lesions. Ten years ago the Food and drug Administration (FDA) approved the first vaccine against HPV. In the last decades, growing data on safety and effectiveness have been collected. In the present review we report the current knowledge on vaccine against HPV, highlighting the current value and prospective regarding the widespread diffusion of HPV vaccines. (Source: Critical Reviews in Oncology Hematology)
Source: Critical Reviews in Oncology Hematology - December 28, 2017 Category: Cancer & Oncology Authors: Giorgio Bogani, Umberto Leone Roberti Maggiore, Mauro Signorelli, Fabio Martinelli, Antonino Ditto, Ilaria Sabatucci, Lavinia Mosca, Domenica Lorusso, Francesco Raspagliesi Source Type: research

Editorial Board
(Source: Critical Reviews in Oncology Hematology)
Source: Critical Reviews in Oncology Hematology - December 24, 2017 Category: Cancer & Oncology Source Type: research

The ethical plausibility of the ‘Right To Try’ laws
‘Right To Try’ (RTT) laws originated in the USA to allow terminally ill patients to request access to early stage experimental medical products directly from the producer, removing the oversight and approval of the Food and Drug Administration. These laws have received significant media attentio n and almost equally unanimous criticism by the bioethics, clinical and scientific communities. They touch indeed on complex issues such as the conflict between individual and public interest, and the public understanding of medical research and its regulation. (Source: Critical Reviews in Oncology Hematology)
Source: Critical Reviews in Oncology Hematology - December 23, 2017 Category: Cancer & Oncology Authors: D. Carrieri, F.A. Peccatori, G. Boniolo Source Type: research

Mucins: Structural diversity, biosynthesis, its role in pathogenesis and as possible therapeutic targets
Mucins are the main structural components of mucus that create a selective protective barrier for epithelial surface and also execute wide range of other physiological functions. Mucins can be classified into two types, namely secreted mucins and membrane bounded mucins. Alterations in mucin expression or glycosylation and mislocalization has been seen in various types of pathological conditions such as cancers, inflammatory bowel disease and ocular disease, which highlight the importance of mucin in maintaining homeostasis. (Source: Critical Reviews in Oncology Hematology)
Source: Critical Reviews in Oncology Hematology - December 22, 2017 Category: Cancer & Oncology Authors: Suresh Sulekha Dhanisha, Chandrasekharan Guruayoorappan, Sudarsanan Drishya, Prathapan Abeesh Source Type: research

Non pharmacological interventions and non-fentanyl pharmacological treatments for breakthrough cancer pain: a systematic and critical review
Background: Oral opioids or other pharmacological or non-pharmacological interventions are often suggested in the management of breakthrough cancer pain (BTcP). The aim of this systematic and critical review was to analyse and critically comment the evidence of any non-fentanyl therapies proposed for BTcP. (Source: Critical Reviews in Oncology Hematology)
Source: Critical Reviews in Oncology Hematology - December 22, 2017 Category: Cancer & Oncology Authors: Sebastiano Mercadante Source Type: research

A systematic review of the safety profile of the different combinations of fluoropyrimidines and oxaliplatin in the treatment of colorectal cancer patients
(Source: Critical Reviews in Oncology Hematology)
Source: Critical Reviews in Oncology Hematology - December 16, 2017 Category: Cancer & Oncology Authors: Chiara Baratelli, Clizia Zichi, Massimo Di Maio, Maria Pia Brizzi, Cristina Sonetto, Giorgio Vittorio Scagliotti, Marco Tampellini Source Type: research

Circulating tumour DNA, a promising biomarker for the management of colorectal cancer
Colorectal cancer (CRC) represents a significant global health burden given that it is the 3rd most common cancer in men and the 2nd most common cancer in women (Ferlay et al., 2015). The disease is curable if diagnosed at an early stage when it may be amenable to surgical resection. In the United Kingdom, it is estimated that a patient with early stage colon cancer would incur a treatment cost of £3400 in the National Health Service compared to £12 500 for a patient with late stage disease. Improvement in early diagnosis is therefore paramount to improve survival and lead to significant cost savings. (Source: Critical R...
Source: Critical Reviews in Oncology Hematology - December 16, 2017 Category: Cancer & Oncology Authors: Shelize Khakoo, Alexandros Georgiou, Marco Gerlinger, David Cunningham, Naureen Starling Source Type: research

The role of stereotactic body radiotherapy in reirradiation of head and neck cancer recurrence
Head and neck cancer recurrence is a therapeutic challenge due to the anatomical and functional constraints of the head and neck area. Stereotactic body radiotherapy (SBRT) is a high-precision technique of radiotherapy that consists of delivering a high ablative biological dose in 1 –5 high-dose fractions, requiring a very high precision of the radiotherapy process with potential application in this clinical setting (Source: Critical Reviews in Oncology Hematology)
Source: Critical Reviews in Oncology Hematology - December 15, 2017 Category: Cancer & Oncology Authors: A. Rom án A., C. Jodar, A. Perez-Rozos, Y. Lupiañez-Perez, J.A. Medina, J. Gomez-Millan Source Type: research

The role of Stereotactic body radiotherapy (SBRT) in reirradiation of Head and Neck cancer recurrence
Head and neck cancer recurrence is a therapeutic challenge due to the anatomical and functional constraints of the head and neck area. Stereotactic body radiotherapy (SBRT) is a high-precision technique of radiotherapy that consists of delivering a high ablative biological dose in 1 –5 high-dose fractions, requiring a very high precision of the radiotherapy process with potential application in this clinical setting. (Source: Critical Reviews in Oncology Hematology)
Source: Critical Reviews in Oncology Hematology - December 15, 2017 Category: Cancer & Oncology Authors: A. Rom án A., C. Jodar, A. Perez-Rozos, Y. Lupiañez-Perez, JA Medina, J. Gomez-Millan Source Type: research

Physical activity reduces fatigue in patients with cancer and hematopoietic stem cell transplant recipients: A systematic review and meta-analysis of randomized trials
(Source: Critical Reviews in Oncology Hematology)
Source: Critical Reviews in Oncology Hematology - December 15, 2017 Category: Cancer & Oncology Authors: Sapna Oberoi, Paula D. Robinson, Danielle Cataudella, Nicole Culos-Reid, Hailey Davis, Nathan Duong, Faith Gibson, Miriam G ötte, Pamela Hinds, Sanne L Nijhof, Deborah Tomlinson, Patrick van der Torre, Sandra Cabral, LLee Dupuis, Lillian Sung Source Type: research

Protective effects of curcumin against doxorubicin-induced toxicity and resistance: a review
Doxorubicin (DOX)-induced toxicity and resistance are major obstacles in chemotherapeutic approaches. Despite effective in the treatment of numerous malignancies, some clinicians have voiced concern that DOX has the potential to cause debilitating consequences in organ tissues, especially the heart. The mechanisms of toxicity and resistance are respectively related to induction of reactive oxygen species (ROS) and up-regulation of ATP-binding cassette (ABC) transporter. Curcumin (CUR) with several biological and pharmacological properties is expected to restore DOX-mediated impairments to tissues. (Source: Critical Reviews...
Source: Critical Reviews in Oncology Hematology - December 14, 2017 Category: Cancer & Oncology Authors: Mohammad Mohajeri, Amirhossein Sahebkar Source Type: research

Systemic treatment in adult uterine sarcomas
Uterine sarcomas (US) are rare mesenchymal tumours of the uterus and are divided mainly into uterine leiomyosarcoma (uLMS), low grade endometrial stromal sarcoma (LG-ESS), high grade endometrial stromal sarcoma (HG-ESS), adenosarcomas and high grade undifferentiated sarcoma (HGUS). US are often high-grade tumours with a high local recurrence rate and metastatic risk. We here discuss the current standard of care and knowledge of systemic therapy for adult uterine sarcomas, in particular uLMS, LG-ESS, HG-ESS and HGUS, in both the adjuvant as well as the metastatic setting. (Source: Critical Reviews in Oncology Hematology)
Source: Critical Reviews in Oncology Hematology - December 14, 2017 Category: Cancer & Oncology Authors: I.M.E. Desar, P.B. Ottevanger, C. Benson, W.T.A. van der Graaf Source Type: research

Anti-hypertensive drugs and skin cancer risk: a review of the literature and meta-analysis
(Source: Critical Reviews in Oncology Hematology)
Source: Critical Reviews in Oncology Hematology - December 13, 2017 Category: Cancer & Oncology Authors: Sara Gandini, Domenico Palli, Giuseppe Spadola, Benedetta Bendinelli, Emilia Cocorocchio, Ignazio Stanganelli, Lucia Miligi, Giovanna Masala, Saverio Caini Source Type: research