Systemic treatment in adult uterine sarcomas

Uterine sarcomas (US) are rare mesenchymal tumours of the uterus and are divided mainly into uterine leiomyosarcoma (uLMS), low grade endometrial stromal sarcoma (LG-ESS), high grade endometrial stromal sarcoma (HG-ESS), adenosarcomas and high grade undifferentiated sarcoma (HGUS). US are often high-grade tumours with a high local recurrence rate and metastatic risk. We here discuss the current standard of care and knowledge of systemic therapy for adult uterine sarcomas, in particular uLMS, LG-ESS, HG-ESS and HGUS, in both the adjuvant as well as the metastatic setting.

Source: Critical Reviews in Oncology Hematology - December 14, 2017 Category: Cancer & Oncology Authors: I.M.E. Desar, P.B. Ottevanger, C. Benson, W.T.A. van der Graaf Source Type: research