Clinical Research in Cardiology Supplements This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Therapeutic apheresis in peripheral and retinal circulatory disorders
Abstract In microcirculation disorders, the therapeutic apheresis seems to have two different effects. The first, achieved after only a few sessions, is acute, consisting of drastic reduction of blood viscosity and obtained with the use of low-density lipoprotein (LDL) apheresis, rheopheresis, or fibrinogen apheresis. The second effect is long term, or chronic, and needs to be evaluated after a long course of treatment. The mechanisms underlying the chronic effect are still objects of debate and take into account the pleiotropic effects of apheresis. However, it is likely that the acute effect of aphere...
Source: Clinical Research in Cardiology Supplements - June 1, 2012 Category: Cardiology Source Type: research

Pharmacogenetic aspects in familial hypercholesterolemia with the special focus on FHMarburg (FH p.W556R)
Conclusions The LDLR mutation p.W556R is a frequent and severe class II defect for FH. The affected homozygote FH patients have a total loss of the functional LDLR and—as expected—do not respond on statin therapy and require LDL apheresis. In contrast, heterozygote FH patients with the same LDLR defect respond exceedingly well to standard lipid-lowering therapy, illustrating that the knowledge of the primary LDLR defect enables us to foresee the expected drug effects. (Source: Clinical Research in Cardiology Supplements)
Source: Clinical Research in Cardiology Supplements - June 1, 2012 Category: Cardiology Source Type: research

Lipid apheresis techniques: current status in Germany
Abstract For long-term lipid apheresis therapy, several different technical systems have been developed which enable effective reduction of LDL cholesterol and other atherogenic lipoproteins, such as Lp(a), with sufficient selectivity and good clinical tolerance. Suitable techniques include whole blood adsorption with polyacrylamide and dextran sulfate cellulose, while primary plasma separation is used for cascade filtration, heparin-induced precipitation, immunoadsorption, silicate gel adsorption, and dextran sulfate cellulose (both techniques). The technical features are described....
Source: Clinical Research in Cardiology Supplements - June 1, 2012 Category: Cardiology Source Type: research

Fibrinogen/LDL apheresis is a promising rescue therapy for sudden sensorineural hearing loss
Conclusion Fibrinogen/LDL apheresis is a promising rescue therapy for sudden sensorineural hearing loss even after unsuccessful other therapies. (Source: Clinical Research in Cardiology Supplements)
Source: Clinical Research in Cardiology Supplements - June 1, 2012 Category: Cardiology Source Type: research

Current view: indications for extracorporeal lipid apheresis treatment
Conclusions There is consensus between the medical societies and health insurance funds regarding the need for general accepted guidelines for lipid apheresis. Recommendations for the indications of lipid apheresis were developed, but additionally these results should be confirmed by medical societies to transform them to guidelines. However, due to limited data showing that lipid apheresis has effects on the progression of cardiovascular diseases all members of the apheresis working group support a project for creating a lipid apheresis registry. This apheresis registry has been developed and recentl...
Source: Clinical Research in Cardiology Supplements - June 1, 2012 Category: Cardiology Source Type: research

Treatment options for severe hypertriglyceridemia (SHTG): the role of apheresis
Abstract Hypertriglyceridemia is associated with a number of severe diseases such as acute pancreatitis and coronary artery disease. In severe hypertriglyceridemia (SHTG, triglycerides > 1,000 mg/dL), rapid lowering of plasma triglycerides (TG) has to be achieved. Treatment regimes include nutritional intervention, the use of antihyperlipidemic drugs, and therapeutic apheresis. Apheretic treatment is indicated in medical emergencies such as hypertriglyceridemic pancreatitis. Reviewing the current literature, plasmapheresis appears to be a safe and useful therapeutic tool in pat...
Source: Clinical Research in Cardiology Supplements - June 1, 2012 Category: Cardiology Source Type: research

Lipid apheresis: oxidative stress, rheology, and vasodilatation
Abstract In the treatment of homozygous and therapy-resistant hypercholesterolemia, lipid apheresis enables not only low density lipoprotein (LDL) cholesterol to be lowered by approximately 60%, but also oxidative stress factors to be influenced and adhesion molecules reduced. This was investigated in a group of 12 patients using the heparin-induced extracorporeal LDL precipitation (H.E.L.P.) procedure. A significant lowering of LDL cholesterol and fibrinogen leads to an improvement in rheology and endothelial function, detectable and measurable within approximately 20 h by assessin...
Source: Clinical Research in Cardiology Supplements - June 1, 2012 Category: Cardiology Source Type: research

Editorial
(Source: Clinical Research in Cardiology Supplements)
Source: Clinical Research in Cardiology Supplements - June 1, 2012 Category: Cardiology Source Type: research