Targeted medicines: how pharmacists can lead a pharmacogenomics revolution
Though commonplace in other countries, pharmacogenomic testing is yet to become a mainstay of NHS healthcare. Here, David Wright and Dhiren Bhatt argue how this process could improve the chance of therapeutic success and why pharmacists should be at the heart of its implementation. (Source: Clinical Pharmacist)
Source: Clinical Pharmacist - June 6, 2018 Category: Drugs & Pharmacology Source Type: research
Prescribing alerts could cut opioid and benzodiazepine coprescribing
An electronic medical record alert system could potentially reduce coprescribing and related overdose deaths, researchers have found. (Source: Clinical Pharmacist)
Source: Clinical Pharmacist - June 6, 2018 Category: Drugs & Pharmacology Source Type: research
Antibiotic prescribing in a clinician-first telephone triage setting in a general practice
In May 2016, a general practice with around 16,000 registrants introduced a clinician-first triage system, which moved the practice ’s more traditional face-to-face approach to one in which the majority of the consultations were conducted over the telephone. As a result, many prescriptions have been issued remotely, including those for antibiotics. As part of the National Institute for Health and Care Excellence’s (NICE) sch olarship programme, a project was initiated to measure the impact ... (Source: Clinical Pharmacist)
Source: Clinical Pharmacist - June 5, 2018 Category: Drugs & Pharmacology Source Type: research
Preconception blood pressure linked to pregnancy loss risk
Interventions to reduce blood pressure may help to improve reproductive outcomes in healthy young women, research has found. (Source: Clinical Pharmacist)
Source: Clinical Pharmacist - June 5, 2018 Category: Drugs & Pharmacology Source Type: research
Pharmacy ’s role in antimicrobial resistance and stewardship
This article summarises the evidence supporting the role of pharmacists and pharmacy teams in antimicrobial stewardship and outlines the impact of their activities. (Source: Clinical Pharmacist)
Source: Clinical Pharmacist - June 5, 2018 Category: Drugs & Pharmacology Source Type: research
Addition of pembrolizumab to chemotherapy extends survival in advanced lung cancer
Introducing first-line immunotherapy could benefit long-term outcomes in advanced non-small-cell lung cancer (NSCLC), a study has revealed. (Source: Clinical Pharmacist)
Source: Clinical Pharmacist - June 4, 2018 Category: Drugs & Pharmacology Source Type: research
DPP-4 inhibitors have no mortality benefit in type 2 diabetes, analysis shows
Dipeptidyl peptidase-4 (DPP-4) inhibitors do not lower death rates in patients with type 2 diabetes, an analysis comparing them with other common treatments has shown. (Source: Clinical Pharmacist)
Source: Clinical Pharmacist - May 31, 2018 Category: Drugs & Pharmacology Source Type: research
NSAIDs preferred choice for acute dental pain, review finds
Use of non-steroidal anti-inflammatory drugs (NSAIDs), with or without paracetamol, can provide a better balance of benefits and risks compared with opioids for the treatment of acute dental pain, a review has revealed. (Source: Clinical Pharmacist)
Source: Clinical Pharmacist - May 30, 2018 Category: Drugs & Pharmacology Source Type: research
Omega-3 supplements do not improve dry eye symptoms, study finds
There is no evidence for the benefit of omega-3 acid supplementation in treating symptoms of dry eye disease, a study has shown. (Source: Clinical Pharmacist)
Source: Clinical Pharmacist - May 29, 2018 Category: Drugs & Pharmacology Source Type: research
Increase in potentially inappropriate medicines use seen in all older adults, study results suggest
After assessing patterns of medicines use in patients with and without dementia, researchers found that the risk of potentially inappropriate medicines use significantly increased in all groups (Source: Clinical Pharmacist)
Source: Clinical Pharmacist - May 22, 2018 Category: Drugs & Pharmacology Source Type: research
Andexanet shows promise in patients taking new anticoagulants
Results from an ongoing trial of 228 patients with acute major bleeding show that patients taking andexanet experienced a reduction in anti-FXa activity. (Source: Clinical Pharmacist)
Source: Clinical Pharmacist - May 21, 2018 Category: Drugs & Pharmacology Source Type: research
Study identifies genes potentially linked to depression
Researchers have identified 14 new independent risk variants associated with depression following a genome-wide association study of 322,580 people. (Source: Clinical Pharmacist)
Source: Clinical Pharmacist - May 18, 2018 Category: Drugs & Pharmacology Source Type: research
Antihypertension diet also lowers depression risk in older adults
It is well known that older adults with cardiovascular risk factors are more likely to experience depression than others. However, research has shown that dietary modification could help lower depression risk in this group. (Source: Clinical Pharmacist)
Source: Clinical Pharmacist - May 14, 2018 Category: Drugs & Pharmacology Source Type: research
Rheumatoid arthritis drug may reduce inflammation after stroke
The pro-inflammatory cytokine interleukin-1 plays a significant role in brain injury following ischemic stroke by inducing peripheral inflammatory mediators, such as interleukin-6. However, pre-clinical studies show its effects are reduced by the interleukin-1 receptor antagonist. (Source: Clinical Pharmacist)
Source: Clinical Pharmacist - May 14, 2018 Category: Drugs & Pharmacology Source Type: research
Refractory epilepsy: management in tertiary care
Epilepsy is a neurological disorder marked by sudden recurrent episodes of sensory disturbance, loss of consciousness or convulsions, associated with neurones exhibiting abnormally high electrical excitability in the brain. (Source: Clinical Pharmacist)
Source: Clinical Pharmacist - May 10, 2018 Category: Drugs & Pharmacology Source Type: research
