Happenings in hinchingbrooke.
PMID: 25468866 [PubMed - in process] (Source: Clinical Medicine)
Source: Clinical Medicine - December 1, 2014 Category: Journals (General) Authors: Borland C Tags: Clin Med Source Type: research
A new kid on the block: the role of physician associates.
PMID: 25468867 [PubMed - in process] (Source: Clinical Medicine)
Source: Clinical Medicine - December 1, 2014 Category: Journals (General) Authors: Ritsema TS Tags: Clin Med Source Type: research
Response.
PMID: 25468868 [PubMed - in process] (Source: Clinical Medicine)
Source: Clinical Medicine - December 1, 2014 Category: Journals (General) Authors: Kuhns DH Tags: Clin Med Source Type: research
The future of general medicine.
PMID: 25468869 [PubMed - in process] (Source: Clinical Medicine)
Source: Clinical Medicine - December 1, 2014 Category: Journals (General) Authors: Oliver D Tags: Clin Med Source Type: research
The history and future of intensive care units.
PMID: 25468870 [PubMed - in process] (Source: Clinical Medicine)
Source: Clinical Medicine - December 1, 2014 Category: Journals (General) Authors: Chadwick A Tags: Clin Med Source Type: research
Clinical and scientific letters.
PMID: 25468871 [PubMed - in process] (Source: Clinical Medicine)
Source: Clinical Medicine - December 1, 2014 Category: Journals (General) Authors: O'Driscoll BR, Grant K, Green D, Edeghere S, Bakerly ND, Murphy P, Edwards V, Turkington PM Tags: Clin Med Source Type: research
Response.
PMID: 25468872 [PubMed - in process] (Source: Clinical Medicine)
Source: Clinical Medicine - December 1, 2014 Category: Journals (General) Authors: Jones M Tags: Clin Med Source Type: research
Treatment of resistant epilepsy.
Abstract
Treatment resistance affects around 20% of people with epilepsy and carries a significant comorbidity. It is important to ensure that the diagnosis of epilepsy is secure and the underlying cause of the epilepsy is investigated thoroughly. Management involves early referral for epilepsy surgery when suitable, optimisation of pharmacological treatment, and consideration of comorbidities such as depression.
PMID: 25468911 [PubMed - in process] (Source: Clinical Medicine)
Source: Clinical Medicine - December 1, 2014 Category: Journals (General) Authors: Pickrell WO, Smith PE Tags: Clin Med Source Type: research
Novel respiratory viruses: what should the clinician be alert for?
Abstract
Since 1990, several novel respiratory viruses affecting humans have been described. In this review, we focus on three pathogens that have caused significant human mortality and raise important public health concerns: severe acute respiratory syndrome (SARS)-coronavirus, Middle East respiratory syndrome (MERS)-coronavirus and avian influenza A viruses (H5N1 and H7N9). Novel respiratory viruses have the potential to instil fear in the public and physicians alike if they are associated with a high case fatality rate. Those viruses with a significant potential for onward human-to-human transmission (i...
Source: Clinical Medicine - December 1, 2014 Category: Journals (General) Authors: Payne B, Bellamy R Tags: Clin Med Source Type: research
Host genetic factors in susceptibility to mycobacterial disease.
Abstract
Primary immunodeficiencies (PID) are a group of rare inherited disorders that manifest as heightened susceptibility to infection, autoimmunity and/or malignancy. By exploring their genetic and cellular aetiology, we can learn much about the basis of pathogen-specific immunity in humans. This is exemplified by mycobacterial susceptibility, which occurs across several types of PID, either as an isolated problem or as part of a broader pattern of susceptibility to infection. These experiments of nature have contributed to our understanding of the central role of T cells in activating infected macroph...
Source: Clinical Medicine - December 1, 2014 Category: Journals (General) Authors: Duncan CJ, Hambleton S Tags: Clin Med Source Type: research
Heart failure with preserved ejection fraction.
Abstract
Many patients with heart failure (HF) have a normal left ventricular ejection fraction, and are labelled as having HF with preserved left ventricular ejection fraction (HFPEF). Hypertension, atrial fibrillation and age are important contributors to the development of HFPEF and, therefore, its prevalence is likely to increase in the next few decades. The pathophysiology of HFPEF is heterogeneous but with a final common pathway leading to congestion. HF remains a clinical diagnosis but the plasma concentration of B-type natriuretic peptide (eg BNP/N-terminal prohormone BNP (NT-proBNP)), a marker of ...
Source: Clinical Medicine - December 1, 2014 Category: Journals (General) Authors: Pellicori P, Cleland JG Tags: Clin Med Source Type: research
Thyroid disease and vascular risk.
Abstract
Subclinical hypothyroidism (SCH) is a common condition seen in up to 10% of adults, mainly women and the elderly. Several prospective longitudinal cohort studies have shown a higher risk of cardiovascular disease in people with SCH but mainly in younger individuals. There are also a number of interventional trials that have shown that treatment of SCH with levo-thyroxine improves cardiovascular risk factors, but there is a dearth of level 1 evidence regarding cardiovascular events. In addition, there is increasing proof concerning the association of abnormal thyroid function at the time of an acut...
Source: Clinical Medicine - December 1, 2014 Category: Journals (General) Authors: Jabbar A, Razvi S Tags: Clin Med Source Type: research
Spatial and temporal cancer evolution: causes and consequences of tumour diversity.
Abstract
Our knowledge of the morphological heterogeneity of cancer has recently been augmented by the genomic heterogeneity revealed by the use of next-generation sequencing technology. We now know that no two cancers are alike and that even different regions within the same tumour vary in their composition. Tumours consist of multiple clonal populations and they evolve under Darwinian principles. This review summarizes some of the causes of such diversity and its implication for cancer management.
PMID: 25468916 [PubMed - in process] (Source: Clinical Medicine)
Source: Clinical Medicine - December 1, 2014 Category: Journals (General) Authors: Hiley CT, Swanton C Tags: Clin Med Source Type: research
Renal denervation: potential indications and review of trial data.
This article will review the evidence to date, the scientific rationale for sympathetic denervation as a treatment for hypertension and consider other possible conditions where the therapy may be of benefit.
PMID: 25468917 [PubMed - in process] (Source: Clinical Medicine)
Source: Clinical Medicine - December 1, 2014 Category: Journals (General) Authors: Raphael CE Tags: Clin Med Source Type: research
Dyslipidaemia: what's around the corner?
This article reviews therapies in development to further lower LDL-cholesterol (Proprotein convertase subtilisin/kexin-9 (PCSK-9) inhibitors), raise HDL-holesterol (cholesterol ester transfer protein inhibitors (CETPIs)) and reduce triglycerides (novel peroxisome proliferator-activated receptor (PPAR)-agonists and omega-3 fatty acid preparations). Specialised therapies are in development for treatment of orphan disoders such as homozygous familial hypercholesterolaemia (lomitapide) or familial chylomicroaemia (alipogene tiparvovec). These novel lipid-lowering agents are likely to find uses in treating patients at the highe...
Source: Clinical Medicine - December 1, 2014 Category: Journals (General) Authors: Wierzbicki AS, Perera D, Ewang-Emukowhate M Tags: Clin Med Source Type: research
