Host genetic factors in susceptibility to mycobacterial disease.

Host genetic factors in susceptibility to mycobacterial disease.
Clin Med. 2014 Dec;14 Suppl 6:s17-21
Authors: Duncan CJ, Hambleton S
Abstract
Primary immunodeficiencies (PID) are a group of rare inherited disorders that manifest as heightened susceptibility to infection, autoimmunity and/or malignancy. By exploring their genetic and cellular aetiology, we can learn much about the basis of pathogen-specific immunity in humans. This is exemplified by mycobacterial susceptibility, which occurs across several types of PID, either as an isolated problem or as part of a broader pattern of susceptibility to infection. These experiments of nature have contributed to our understanding of the central role of T cells in activating infected macrophages to eliminate phagosomal mycobacteria through mutually activating, cytokine-dependent interactions. In recent years, the discovery of novel forms of PID has emphasised the important role of dendritic cells and monocytes in mycobacterial defence in humans. Here, we provide a brief overview of these new disorders alongside other genetic causes of susceptibility to mycobacterial disease.
PMID: 25468913 [PubMed - in process]

Source: Clinical Medicine - December 1, 2014 Category: Journals (General) Authors: Duncan CJ, Hambleton S Tags: Clin Med Source Type: research