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Effectiveness of Liraglutide in Type II Diabetes Mellitus Management: Experience in Emirati Patients
Conclusions: Liraglutide is effective in reducing HbA1C, weight, and to a lesser extent, SBP in Emirati patients. (Source: Clinical Medicine Insights: Endocrinology and Diabetes)
Source: Clinical Medicine Insights: Endocrinology and Diabetes - September 20, 2015 Category: Endocrinology Authors: Nasrullah K. GhumanLoai M. SaadahMajdi S. Al NajjarDuha Y. ShaheenShady I. AMMouza M. Al Ali Source Type: research

Parathyroidectomy Ameliorates Glucose and Blood Pressure Control in a Patient with Primary Hyperparathyroidism, Type 2 Diabetes, and Hypertension
Effect of parathyroidectomy on glucose control and hypertension is controversial. Here, we report a case of a patient with primary hyperparathyroidism, type 2 diabetes mellitus, and hypertension in whom parathyroidectomy ameliorated both glucose control and blood pressure. Once high serum calcium levels were noticed, ultrasonography of neck confirmed a well-defined oval hypoechoic mass posterior to the right lobe of the thyroid, confirmed by scintiscan. Parathyroidectomy resulted in improvement of blood pressure and blood glucose. We could stop insulin and antihypertensive medications. We conclude that in patients with typ...
Source: Clinical Medicine Insights: Endocrinology and Diabetes - September 2, 2015 Category: Endocrinology Authors: Alok KumarSunita Singh Source Type: research

Androgen Deficiency and Erectile Dysfunction in Patients with Type 2 Diabetes
Conclusion: LST, symptoms of androgen deficiency, and ED are common in the studied sample of Egyptian men with T2DM. Inappropriately normal FSH and LH in face of LST may denote a state of hypogonadotropic hypogonadism. HBA1c was found to be more significantly associated with ED than with LST. (Source: Clinical Medicine Insights: Endocrinology and Diabetes)
Source: Clinical Medicine Insights: Endocrinology and Diabetes - July 19, 2015 Category: Endocrinology Authors: Entesar O.A. El SaghierSalah E. SheblOlfat A. FawzyIhab M. EltayebLamya M.A. BekhetAbdelnasser Gharib Source Type: research

Effect of Habitual Khat Chewing on Glycemic Control, Body Mass Index, and Age at Diagnosis of Diabetes in Patients with Type 2 Diabetes Mellitus in Yemen
Khat chewing is common in Yemen. We conducted this study to see if it affected diabetes control in patients with type 2 diabetes mellitus (DM). We studied 1540 patients with type 2 DM attending an endocrinology clinic in Sana’a, Yemen, of which 997 were khat chewers (KC) and 543 were non-khat chewers (NKC). The patients answered a questionnaire regarding khat chewing. Hemoglobin A1c (HbA1c) and body mass index (BMI) were measured. KC had a higher mean HbA1c of 9.8 (95% confidence interval (95% CI) 9.6–10) than the NKC, with a mean of 9.1 (95% CI 8.9–9.4) (adjusted odds ratios (AOR) 1.74, P < 0.001) after multivariate...
Source: Clinical Medicine Insights: Endocrinology and Diabetes - June 2, 2015 Category: Endocrinology Authors: Butheinah A. Al-SharafiAbdallah A. Gunaid Source Type: research

Changes in the Prevalence of Diabetes Mellitus in Bulgaria (2006 & ndash;2012)
Aim: The aim of this study was to compare two nationwide cross-sectional studies of diabetes prevalence in Bulgaria (2006 and 2012) and to assess its dynamics. Material and Methods: The two studies included 2396 and 2033 subjects, respectively. The International Diabetes Federation (IDF) diagnostic criteria were applied, and the data were weighed for type of settlement and age. Results: Diabetes prevalence was found to be 7.9% in 2006 and 9.55% in 2012, P = 0.06, showing an increase of 20.9%. The absolute increase was 0.9% in the females and 2.3% in the males (P (Source: Clinical Medicine Insights: Endocrinology and Diabetes)
Source: Clinical Medicine Insights: Endocrinology and Diabetes - May 12, 2015 Category: Endocrinology Authors: Anna-Maria Borissova Alexander Shinkov Roussanka Kovatcheva Jordan Vlahov Lilia Dakovska Todor Todorov Source Type: research

Changes in the Prevalence of Diabetes Mellitus in Bulgaria (2006–2012)
Conclusions: A significant increase in diabetes prevalence was found that necessitates healthcare measures and resources for community-based awareness and prevention programs. (Source: Clinical Medicine Insights: Endocrinology and Diabetes)
Source: Clinical Medicine Insights: Endocrinology and Diabetes - May 12, 2015 Category: Endocrinology Authors: Anna-Maria BorissovaAlexander ShinkovRoussanka KovatchevaJordan VlahovLilia DakovskaTodor Todorov Source Type: research

Predictors of Abnormal Bone Mass Density in Adult Patients with Homozygous Sickle-Cell Disease
Background: Adult patients with sickle-cell disease (SCD) often have multiple bone compactions causing tissue hypoxia and osteonecrosis. The impact on bone abnormalities lesion detected by bone mass density is not well defined. Aim: The study is a cross sectional, perspective was designed to assess the prevalence of abnormal BMD in adult Bahraini patients with SCD and to assess the predictive risk of different metabolic variables such as serum level of vitamin D3, testosterone, and parathyroid hormone in addition to lactate dehydrogenase (LDH), hemoglobin (Hb), and reticulocyte count for the development of abnormal bone de...
Source: Clinical Medicine Insights: Endocrinology and Diabetes - May 7, 2015 Category: Endocrinology Authors: Taysir S. GaradahAdla B. HassanAhmed A. JaradatDiab E. DiabHiba O. KalafallaAdel K. KalifaReginald P. SequeiraAbdul Hameed A. Alawadi Source Type: research

The Relationship between Thyroid Function and Depressive Symptoms & mdash;the FIN-D2D Population-Based Study
This study draws on a random, population-based sample of 4500 subjects aged 45–75 years old from Finland. The basic clinical study was done in 2007 for 1396 men and 1500 women (64% participation rate). Thyroid stimulating hormone (TSH), free thyroxine (F-T4), and free triiodothyronine (F-T3) were measured in 2013 from frozen samples. The 21-item Beck Depression Inventory (BDI-21) was applied to assess depressive symptoms (score ≥10 points). The prevalence of depressive symptoms was 17.5% in women and 12.5% in men. In women, the mean levels of TSH, F-T4, and F-T3 without depressive symptoms vs. with the presence of depr...
Source: Clinical Medicine Insights: Endocrinology and Diabetes - April 20, 2015 Category: Endocrinology Authors: Juha Saltevo Hannu Kautiainen Pekka M äntyselkä Antti Jula Sirkka Kein änen-Kiukaanniemi Eeva Korpi-Hy övälti Heikki Oksa Timo Saaristo Mauno Vanhala Source Type: research

The Relationship between Thyroid Function and Depressive Symptoms—the FIN-D2D Population-Based Study
This study draws on a random, population-based sample of 4500 subjects aged 45–75 years old from Finland. The basic clinical study was done in 2007 for 1396 men and 1500 women (64% participation rate). Thyroid stimulating hormone (TSH), free thyroxine (F-T4), and free triiodothyronine (F-T3) were measured in 2013 from frozen samples. The 21-item Beck Depression Inventory (BDI-21) was applied to assess depressive symptoms (score ≥10 points). The prevalence of depressive symptoms was 17.5% in women and 12.5% in men. In women, the mean levels of TSH, F-T4, and F-T3 without depressive symptoms vs. with the presence of depr...
Source: Clinical Medicine Insights: Endocrinology and Diabetes - April 20, 2015 Category: Endocrinology Authors: Juha SaltevoHannu KautiainenPekka MäntyselkäAntti JulaSirkka Keinänen-KiukaanniemiEeva Korpi-HyövältiHeikki OksaTimo SaaristoMauno Vanhala Source Type: research

Immune Checkpoint Inhibitor Therapy Associated Hypophysitis
Ipilimumab is a monoclonal antibody directed against CTLA4 T-lymphocyte antigen used as cancer therapy. Immune-related adverse events are common side effects and may include hypophysitis-related hypopituitarism. The clinical features of six patients with ipilimumab-induced hypophysitis (IH) are described. The clinical features of IH reported in clinical trials, including the incidence of IH by gender and the likelihood of adrenal axis recovery, are summarized. Following the development of IH, most patients remain on glucocorticoid replacement despite efforts to withdraw therapy. Analysis of gender information in published ...
Source: Clinical Medicine Insights: Endocrinology and Diabetes - March 25, 2015 Category: Endocrinology Authors: Moeber MahzariDora LiuAmel ArnaoutHeather Lochnan Source Type: research

Health Economic Evaluation of Type 2 Diabetes Mellitus: A Clinical Practice Focused Review
Type 2 diabetes mellitus (T2D) is a growing healthcare burden primarily due to long-term complications. Strict glycemic control helps in preventing complications, and early introduction of insulin may be more cost-effective than maintaining patients on multiple oral agents. This is an expert opinion review based on English peer-reviewed articles (2000–2012) to discuss the health economic consequences of T2D treatment intensification. T2D costs are driven by inpatient care for treatment of diabetes complications (40%–60% of total cost), with drug therapy for glycemic control representing 18% of the total cost. Insulin t...
Source: Clinical Medicine Insights: Endocrinology and Diabetes - March 24, 2015 Category: Endocrinology Authors: Andreas LieblKamlesh KhuntiDomingo Orozco-BeltranJean-Francois Yale Source Type: research

Unhealthy Weight Control Practices: Culprits and Clinical Recommendations
Preoccupation with weight status and a desire to lose weight appears common. Many individuals seek “magic bullet” approaches to weight loss and waive the risks of using these products. In this paper, we review the challenges of weight maintenance, highlight some unhealthy weight control practices, and discuss the futility and potential danger of unregulated weight control agents. Novel clinical strategies are discussed that health care providers may use to triage patients with obesity in an attempt to make ethical and personalized treatment decisions. (Source: Clinical Medicine Insights: Endocrinology and Diabetes)
Source: Clinical Medicine Insights: Endocrinology and Diabetes - February 17, 2015 Category: Endocrinology Authors: Zachary Michael FerraroSean PattersonJean-Philippe Chaput Source Type: research

Combination of Linagliptin and Metformin for the Treatment of Patients with Type 2 Diabetes
Type 2 diabetes mellitus (T2DM) is a progressive condition requiring long-term treatment. Most patients with T2DM are unable to maintain normoglycemia using metformin alone; thus, combination therapy is a pivotal part of disease management. Addition of the dipeptidyl peptidase-4 inhibitor linagliptin, with its proven efficacy, low propensity for hypoglycemia, and weight neutrality, has been shown to improve glycemic control for patients who are not well controlled with metformin. As patients often have other comorbidities requiring pharmacotherapy, an increase in pill number, different prescribing frequencies, and timing o...
Source: Clinical Medicine Insights: Endocrinology and Diabetes - January 4, 2015 Category: Endocrinology Authors: Thomas Haak Source Type: research