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No Postoperative Adrenal Insufficiency in a Patient with Unilateral Cortisol-Secreting Adenomas Treated with Mifepristone Before Surgery
Background: Glucocorticoid replacement is commonly required to treat secondary adrenal insufficiency after surgical resection of unilateral cortisol-secreting adrenocortical adenomas. Here, we describe a patient with unilateral cortisol-secreting adenomas in which the preoperative use of mifepristone therapy was associated with recovery of the hypothalamic–pituitary–adrenal (HPA) axis, eliminating the need for postoperative glucocorticoid replacement. Case Presentation: A 66-year-old Caucasian man with type 2 diabetes mellitus, hyperlipidemia, hypertension, and obesity was hospitalized for Fournier’s gangrene and me...
Source: Clinical Medicine Insights: Endocrinology and Diabetes - July 25, 2016 Category: Endocrinology Authors: Rachel M. Saroka Michael P. Kane Lawrence Robinson Robert S. Busch Source Type: research

Changes in Characteristics and Treatment Patterns of Patients with Newly Diagnosed Type 2 Diabetes in a Large United States Integrated Health System between 2008 and 2013
To assess changes in the clinical characteristics and treatment patterns of patients with newly diagnosed type 2 diabetes (T2D), the electronic health record system at Cleveland Clinic was used to create cross-sectional summaries of all patients with new-onset T2D in 2008 and 2013. Differences between the 2008 and 2013 data sets were assessed after adjusting for age, gender, race, and income. Approximately one-third of patients with newly diagnosed T2D in 2008 and 2013 had an A1C ≥8%, suggesting the continued presence of a delayed recognition of the disease. Patients with newly diagnosed T2D in 2008 were older than those...
Source: Clinical Medicine Insights: Endocrinology and Diabetes - June 29, 2016 Category: Endocrinology Authors: Kevin M. Pantalone Todd M. Hobbs Brian J. Wells Sheldon X. Kong Michael W. Kattan Jonathan Bouchard Kevin M. Chagin Changhong Yu Brian Sakurada Alex Milinovich Wayne Weng Janine M. Bauman Robert S. Zimmerman Source Type: research

Screening for Type II Diabetes Mellitus in the United States: The Present and the Future
The number of individuals being diagnosed with type II diabetes in the United States is increasing. The screening tests for diabetes are able to detect the vast majority of diabetics. However, they do not represent the high-risk individuals who may be prone to diabetes at an earlier age. This brief communication looks at the current screening practices and the gaps in the guidelines. (Source: Clinical Medicine Insights: Endocrinology and Diabetes)
Source: Clinical Medicine Insights: Endocrinology and Diabetes - June 12, 2016 Category: Endocrinology Authors: Ayesha Abid Shahla Ahmad Abdul Waheed Source Type: research

Reported Benefits of Insulin Therapy for Better Glycemic Control in Type 2 Diabetic Patients & mdash;Is This Applicable in Saudi Patients?
Conclusion: Insulin therapy, without adequate diabetes education, fails to control hyperglycemia adequately in Saudi T2DM patients. There is a challenge to find out reasons for poor control and the ways as to how to improve glycemic control in T2DM. (Source: Clinical Medicine Insights: Endocrinology and Diabetes)
Source: Clinical Medicine Insights: Endocrinology and Diabetes - June 7, 2016 Category: Endocrinology Authors: Wafaa AlSaggaf Mohammed Asiri Balgees Ajlan Alaa Bin Afif Roaa Khalil Anas Bin Salman Ahmed Alghamdi Osama Bashawieh Atheer Alamoudi Abeer Aljahdali Nouf Aljahdali Hussam Patwa Mohammed Bakhaidar Suhad M. Bahijri Maimoona Ahmed Khalid Al-Shali Samia Bokha Source Type: research

Reported Benefits of Insulin Therapy for Better Glycemic Control in Type 2 Diabetic Patients—Is This Applicable in Saudi Patients?
Conclusion: Insulin therapy, without adequate diabetes education, fails to control hyperglycemia adequately in Saudi T2DM patients. There is a challenge to find out reasons for poor control and the ways as to how to improve glycemic control in T2DM. (Source: Clinical Medicine Insights: Endocrinology and Diabetes)
Source: Clinical Medicine Insights: Endocrinology and Diabetes - June 7, 2016 Category: Endocrinology Authors: Wafaa AlSaggafMohammed AsiriBalgees AjlanAlaa Bin AfifRoaa KhalilAnas Bin SalmanAhmed AlghamdiOsama BashawiehAtheer AlamoudiAbeer AljahdaliNouf AljahdaliHussam PatwaMohammed BakhaidarSuhad M. BahijriMaimoona AhmedKhalid Al-ShaliSamia BokhariAmani Alhozali Source Type: research

Clinical and Biochemical Characteristics of Diabetes Ketoacidosis in a Tertiary Hospital in Riyadh
Diabetes is the fifth leading cause of death worldwide. Diabetic ketoacidosis (DKA) is a life-threatening acute complication of diabetes. The aim of this study is to investigate the clinical and biochemical characteristics of DKA among 400 patients admitted to hospital, most of whom had type 1 diabetes (n = 372; 93%). Vomiting (n = 319; 79.8%), nausea (n = 282; 70.5%), and abdominal pain (n = 303; 75.8%) were the presenting symptoms most commonly experienced by the patients. Tachycardia was the most common clinical sign noted in the patients on admission (n = 243; 61.8%). The predominant precipitating cause of DKA was nonc...
Source: Clinical Medicine Insights: Endocrinology and Diabetes - May 17, 2016 Category: Endocrinology Authors: Mussa H. Almalki Badurudeen Mahmood Buhary Shawana Abdulhamid Khan Abdulrahman Almaghamsi Fahad Alshahrani Source Type: research

Diabetes Mellitus, a New Risk Factor for Lumbar Spinal Stenosis: A Case & ndash;Control Study
This study aimed to determine the prevalence of diabetes mellitus in patients with spinal stenosis and lumbar vertebral disk degeneration, and the correlation of diabetes with these diseases. Study design: This is a cross-sectional study. Methods: This case–control study was performed during 2012–2014 with 110 patients suffering from lumbar spinal stenosis and 110 patients with lumbar disk herniation, who were diagnosed using clinical and radiological evidences. Additionally, 110 participants who were referred to the clinic and did not show clinical signs of degenerative diseases of the lumbar spine entered the study...
Source: Clinical Medicine Insights: Endocrinology and Diabetes - May 4, 2016 Category: Endocrinology Authors: Leila Asadian Kaveh Haddadi Mohsen Aarabi Amirhossein Zare Source Type: research

Diabetes Mellitus, a New Risk Factor for Lumbar Spinal Stenosis: A Case & ndash;Control Study
Conclusions: There is an association between diabetes and lumbar spinal stenosis. Diabetes mellitus may be a predisposing factor for the development of lumbar spinal stenosis. (Source: Clinical Medicine Insights: Endocrinology and Diabetes)
Source: Clinical Medicine Insights: Endocrinology and Diabetes - May 4, 2016 Category: Endocrinology Authors: Leila Asadian Kaveh Haddadi Mohsen Aarabi Amirhossein Zare Source Type: research

Diabetes Mellitus, a New Risk Factor for Lumbar Spinal Stenosis: A Case–Control Study
Conclusions: There is an association between diabetes and lumbar spinal stenosis. Diabetes mellitus may be a predisposing factor for the development of lumbar spinal stenosis. (Source: Clinical Medicine Insights: Endocrinology and Diabetes)
Source: Clinical Medicine Insights: Endocrinology and Diabetes - May 4, 2016 Category: Endocrinology Authors: Leila AsadianKaveh HaddadiMohsen AarabiAmirhossein Zare Source Type: research

Genetically Targeted Dipeptidyl Peptidase-4 Inhibitor Use in a Patient with a Novel Mutation of MODY type 4
Maturity onset diabetes of the young (MODY) is a rare form of diabetes mellitus typically seen in young adults that results from pancreatic beta-cell dysfunction. MODY4 is a rare subtype caused by a PDX1 mutation. In this case, we present a nonobese 26-year-old male with polyuria and polydipsia. Lab work showed a blood glucose of 511 mg/dL, no ketones or antibodies (insulin, islet cell, and glutamic acid decarboxylase GAD), C-peptide of 1.6 ng/mL, and A1c 9.3%. Genetic analysis revealed a novel nonsense mutation in the PDX1 gene, consistent with MODY type 4. Given this patient’s particular genetic mutation affecting the ...
Source: Clinical Medicine Insights: Endocrinology and Diabetes - October 27, 2015 Category: Endocrinology Authors: Christian MangrumEric RushVijay Shivaswamy Source Type: research

Canagliflozin Treatment in Patients with Type 2 Diabetes Mellitus
Current guidelines for treatment of type 2 diabetes mellitus (T2DM) indicate a patient-centered approach that should go beyond glycemic control. Of the many antihyperglycemic agents available for treatment of T2DM, sodium-glucose cotransporter 2 (SGLT2) inhibitors offer the advantages of reduced glycated hemoglobin (A1C), body weight (BW), and systolic blood pressure (SBP) and are associated with a low risk of hypoglycemia when used either as monotherapy or with other agents not typically associated with increased risk of hypoglycemia. Collaborative, multidisciplinary teams are best suited to provide care to patients with ...
Source: Clinical Medicine Insights: Endocrinology and Diabetes - October 18, 2015 Category: Endocrinology Authors: Curtis TriplittSusan Cornell Source Type: research