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Cardiovascular Genetic Risk Testing for Targeting Statin Therapy in the Primary Prevention of Atherosclerotic Cardiovascular Disease: A Cost-Effectiveness Analysis [Original Articles]
Conclusions: Testing for a 27-single-nucleotide polymorphism cGRS is generally not a cost-effective approach for targeting statin therapy in the primary prevention of ASCVD for low- to intermediate-risk patients. (Source: Circulation: Cardiovascular Quality and Outcomes)
Source: Circulation: Cardiovascular Quality and Outcomes - April 12, 2018 Category: Cardiology Authors: Jarmul, J., Pletcher, M. J., Hassmiller Lich, K., Wheeler, S. B., Weinberger, M., Avery, C. L., Jonas, D. E., Earnshaw, S., Pignone, M. Tags: Cardiovascular Disease, Primary Prevention, Risk Factors, Genetics, Cost-Effectiveness Original Articles Source Type: research

Racial Heterogeneity in Treatment Effects in Peripheral Artery Disease: Insights From the CLEVER Trial (Claudication: Exercise Versus Endoluminal Revascularization) [Data Report]
(Source: Circulation: Cardiovascular Quality and Outcomes)
Source: Circulation: Cardiovascular Quality and Outcomes - April 11, 2018 Category: Cardiology Authors: Pokharel, Y., Jones, P. G., Graham, G., Collins, T., Regensteiner, J. G., Murphy, T. P., Cohen, D., Spertus, J. A., Smolderen, K. Tags: Health Services Data Report Source Type: research

Letter by Hochman and Maron Regarding Article, "'Faith Healing and 'Subtraction Anxiety in Unblinded Trials of Procedures: Lessons From DEFER and FAME-2 for End Points in the ISCHEMIA Trial." [Letter to the Editor]
(Source: Circulation: Cardiovascular Quality and Outcomes)
Source: Circulation: Cardiovascular Quality and Outcomes - April 10, 2018 Category: Cardiology Authors: Hochman, J. S., Maron, D. J. Tags: Percutaneous Coronary Intervention, Quality and Outcomes Letter to the Editor Source Type: research

Health Status Variation Across Practices in Outpatients With Heart Failure: Insights From the CHAMP-HF (Change the Management of Patients With Heart Failure) Registry [Original Articles]
Conclusions: In a large, contemporary registry of outpatients with chronic heart failure with reduced ejection fraction, we observed significant practice-level variability in patients’ health status. Quantifying patients’ health status as a measure of quality should be explored as a foundation for improving care. Clinical Trial Registration: URL: https://www.centerwatch.com. Unique identifier: TX144901. (Source: Circulation: Cardiovascular Quality and Outcomes)
Source: Circulation: Cardiovascular Quality and Outcomes - April 7, 2018 Category: Cardiology Authors: Khariton, Y., Hernandez, A. F., Fonarow, G. C., Sharma, P. P., Duffy, C. I., Thomas, L., Mi, X., Albert, N. M., Butler, J., McCague, K., Nassif, M. E., Williams, F. B., DeVore, A., Patterson, J. H., Spertus, J. A. Tags: Heart Failure, Health Services, Quality and Outcomes Original Articles Source Type: research

An Observational Study of the Association of Video- Versus Text-Based Informed Consent With Multicenter Trial Enrollment: Lessons From the PALM Study (Patient and Provider Assessment of Lipid Management) [Original Articles]
Conclusions: In this observational study of recruitment in a multicenter registry, sites approved for video consent use enrolled the same number of patients as sites with only traditional text-based informed consent but had faster speed to first patient enrolled and more often enrolled older and nonwhite patients. Future randomized trials are needed to assess the impact of video consent on enrollment mechanics and demographics. CLINICAL TRIAL REGISTRATION: URL: https://www.clinicaltrials.gov. Unique identifier: NCT02341664 (Source: Circulation: Cardiovascular Quality and Outcomes)
Source: Circulation: Cardiovascular Quality and Outcomes - April 6, 2018 Category: Cardiology Authors: Fanaroff, A. C., Li, S., Webb, L. E., Miller, V., Navar, A. M., Peterson, E. D., Wang, T. Y. Tags: Clinical Studies, Health Services Original Articles Source Type: research

Abstract 282: The Effect of State Medicaid Expansions on Acute Myocardial Infarction Care Quality and Outcomes [Session Title: Poster Session PM]
Conclusions: States that elected to expand Medicaid did not experience significant improvements in AMI care quality or in-hospital mortality compared with non-expansion states. (Source: Circulation: Cardiovascular Quality and Outcomes)
Source: Circulation: Cardiovascular Quality and Outcomes - April 5, 2018 Category: Cardiology Authors: Wadhera, R. K., Bhatt, D. L., Wang, T. Y., Lu, D., Lucas, J., Garratt, K. N., Yeh, R. W., Joynt Maddox, K. E. Tags: Session Title: Poster Session PM Source Type: research

Abstract 281: Contemporary Epidemiology of Atrial Fibrillation Among Medicare Beneficiaries, 2004-2013 [Session Title: Poster Session PM]
Conclusions: Between years 2004 and 2013, the overall incidence and prevalence of AF among a 5% sample of Medicare beneficiaries stabilized. There were, however, differences across racial groups, with a slight decline in incidence among white men and women, which was not observed in black men and women. (Source: Circulation: Cardiovascular Quality and Outcomes)
Source: Circulation: Cardiovascular Quality and Outcomes - April 5, 2018 Category: Cardiology Authors: Parker, J., Khera, R., Pandey, A., Cheeran, D., Ayers, C., Das, S. R., Link, M. S., de Lemos, J. A., Berry, J. D. Tags: Session Title: Poster Session PM Source Type: research

Abstract 280: Strength of Clinical Trial Evidence for High-Risk Cardiovascular Devices Approved Through Food and Drug Administration (FDA) Priority Review [Session Title: Poster Session PM]
Conclusions and Relevance: Most priority review pathway high-risk cardiovascular devices are approved without a randomized or blinded trial. Noninferiority design and use of surrogate endpoints are common. These devices are frequently subject to recalls. (Source: Circulation: Cardiovascular Quality and Outcomes)
Source: Circulation: Cardiovascular Quality and Outcomes - April 5, 2018 Category: Cardiology Authors: Jones, C., Dhruva, S. S., Redberg, R. F. Tags: Session Title: Poster Session PM Source Type: research

Abstract 279: Eligibility and Cost Estimates for Anti-inflammatory Therapy for Atherosclerotic Disease: Implications of the CANTOS Trial for the US Adult Population [Session Title: Poster Session PM]
Conclusion: Nearly 1 in 3 or 2.1 million US adults with a prior MI are potential treatment candidates. Assuming current canakinumab prices would incur an annual financial burden of up to 124 billion dollars in the United States. Further work is needed to define the population that achieves favorable value with treatment. (Source: Circulation: Cardiovascular Quality and Outcomes)
Source: Circulation: Cardiovascular Quality and Outcomes - April 5, 2018 Category: Cardiology Authors: Khera, R., Saxena, A., Hong, J., Arrieta, A., Ross, J. S., Krumholz, H. M., Nasir, K. Tags: Session Title: Poster Session PM Source Type: research

Abstract 278: Trends in Prescribing Patterns for Patients Hospitalized With Heart Failure With Preserved Ejection Fraction Before and After Clinical Trial Presentation [Session Title: Poster Session PM]
Conclusions: The prescribing rates for MRAs in HFpEF at hospital discharge modestly increased over time, with little discernible influence of TOPCAT. These findings suggest therehas been gradual, modest MRA adoption in the absence of other therapeutic options and highlight the need for further trials on the efficacy and safety of MRAs in HFpEF. (Source: Circulation: Cardiovascular Quality and Outcomes)
Source: Circulation: Cardiovascular Quality and Outcomes - April 5, 2018 Category: Cardiology Authors: Brophy, T. J., Wu, J., Kelly, J. P., DeVore, A. D., Hammill, B. G., Peterson, E. D., Pitt, B., Yancy, C. W., Fonarow, G. C., Hernandez, A. F. Tags: Session Title: Poster Session PM Source Type: research

Abstract 277: Comparison of All-Cause Hospitalization Rates and 30-Day Readmissions Among Patients With Non-Valvular Atrial Fibrillation, Newly Diagnosed and Newly Treated With Dabigatran, Rivaroxaban or Warfarin [Session Title: Poster Session PM]
Conclusions: Adjusted results show dabigatran patients had significantly lower all-cause hospitalization compared to rivaroxaban and warfarin patients. Fewer dabigatran patients experienced a 30-day readmission post-discharge compared to warfarin patients and similar 30-day readmission post-discharge compared to rivaroxaban patients. (Source: Circulation: Cardiovascular Quality and Outcomes)
Source: Circulation: Cardiovascular Quality and Outcomes - April 5, 2018 Category: Cardiology Authors: Gilligan, A., Franchino-Elder, J., Song, X., Wang, C., Henriques, C., Sainski-Nguyen, A., Wilson, K., Smith, D., Sander, S. Tags: Session Title: Poster Session PM Source Type: research

Abstract 276: Identification of Echocardiographic Imaging View Using Deep Learning [Session Title: Poster Session PM]
Conclusion: Vendor independent deep learning networks can rapidly and accurately identify features on standard echocardiogram images. DenseNet network architecture matched human level performance. Deep learning has the potential for rapid, automated image interpretation and can improve the accuracy and efficiency of echocardiogram interpretation. (Source: Circulation: Cardiovascular Quality and Outcomes)
Source: Circulation: Cardiovascular Quality and Outcomes - April 5, 2018 Category: Cardiology Authors: Long, G., Wessler, B. S. Tags: Session Title: Poster Session PM Source Type: research

Abstract 275: Effects of Index Admission Length of Stay on Readmission Interval in Patients With Heart Failure [Session Title: Poster Session PM]
Conclusion: In our patients admitted with heart failure, 8 to 13-day index admission was associated with the longest readmission interval. It is possible that shorter index admission may not allow for sufficient medical optimization. This conclusion requires further study. While patients with prolonged index admission are more likely to have IDDM and CKD, these co-morbidities do not appear to result in shorter readmission intervals. There may be additional, currently not well investigated factors affecting readmission interval. Further research is needed to define optimal LOS and discharge criteria in patients admitted wit...
Source: Circulation: Cardiovascular Quality and Outcomes - April 5, 2018 Category: Cardiology Authors: Breen, T. J., Patel, H., Purga, S., Fein, S. A., Philbin, E. F., Torosoff, M. Tags: Session Title: Poster Session PM Source Type: research

Abstract 273: The Evolving Use of Cardiac CT to Inform Defining Quality in Imaging [Session Title: Poster Session PM]
Conclusion: Cardiac CT utilization is rising for inpatient chest pain and for TAVR planning. For 90% of the patients undergoing evaluation for chest pain, and 90% of patients with equivocal stress testing, cardiac CT potentially prevented need for further downstream invasive testing. This hypothesis-generating data has potential implications that may inform application of quality standards for TAVR and chest pain imaging. Further research is needed to disseminate the effect of cardiac CT on patient outcomes in this cohort. (Source: Circulation: Cardiovascular Quality and Outcomes)
Source: Circulation: Cardiovascular Quality and Outcomes - April 5, 2018 Category: Cardiology Authors: Zhang, M., Earls, J., Choi, B. G., Zeman, R. K., Choi, A. D. Tags: Session Title: Poster Session PM Source Type: research

Abstract 272: Female Sex and Variations in Troponin Utilization [Session Title: Poster Session PM]
Conclusion: There is significant variation in the utilization of troponin testing across VA facilities. Our findings suggests that a patient’s sex may help explain the variation in troponin utilization. Further studies should explore whether sex differences in troponin testing account for discrepancies in outcomes and procedure utilization for patients with AMI. (Source: Circulation: Cardiovascular Quality and Outcomes)
Source: Circulation: Cardiovascular Quality and Outcomes - April 5, 2018 Category: Cardiology Authors: Chui, P. W., Hauser, G. R. Tags: Session Title: Poster Session PM Source Type: research