Establishment and characterization of CRISPR/Cas9 ‐mediated NF2‐/‐ human mesothelial cell line: Molecular insight into FGFR2 in MPM
This article is protected by copyright. All rights reserved. (Source: Cancer Science)
Source: Cancer Science - November 12, 2018 Category: Cancer & Oncology Authors: Md Wahiduzzaman, Sivasundaram Karnan, Akinobu Ota, Ichiro Hanamura, Hideki Murakami, Akihito Inoko, Md Lutfur Rahman, Toshinori Hyodo, Hiroyuki Konishi, Shinobu Tsuzuki, Yoshitaka Hosokawa Tags: Original Article Source Type: research

DEPDC1 predicts prognosis of hepatocellular carcinoma patients and regulates tumor proliferation and metastasis
This article is protected by copyright. All rights reserved. (Source: Cancer Science)
Source: Cancer Science - November 12, 2018 Category: Cancer & Oncology Authors: Qu Di, Feng Cui, Dan Lu, Yu Yang, Yuqing Xu Tags: Original Article Source Type: research

Estrogen Receptor Variant ER ‐α36 Promotes Tamoxifen Agonist Activity in Glioblastoma Cells
This article is protected by copyright. All rights reserved. (Source: Cancer Science)
Source: Cancer Science - November 11, 2018 Category: Cancer & Oncology Authors: Chao Qu, Jingyun Ma, Yejun Zhang, Chao Han, Liang Huang, Liming Shen, Hongyan Li, Xiaobo Wang, Jing Liu, Wei Zou Tags: Original Article Source Type: research

Identification of TRA ‐1‐60‐positive cells as a potent refractory population in follicular lymphomas
This article is protected by copyright. All rights reserved. (Source: Cancer Science)
Source: Cancer Science - November 11, 2018 Category: Cancer & Oncology Authors: Katsuyoshi Takata, Ken Saito, Satoshi Maruyama, Tomoko Miyata ‐Takata, Hidekazu Iioka, Shujiro Okuda, Yiwei Ling, Kennosuke Karube, Yukari Miki, Yoshinobu Maeda, Tadashi Yoshino, Christian Steidl, Eisaku Kondo Tags: Original Article Source Type: research

Primary breast diffuse large B ‐cell lymphoma in the rituximab era: Therapeutic strategies and patterns of failure
Primary breast diffuse large B ‐cell lymphoma (PB‐DLBCL) has a continuous pattern of relapse, especially with frequent late relapses in the central nervous system (CNS) and contralateral breast. Rituximab and radiotherapy confer complementary benefit in the reduction of relapse. However, neither the addition of rituximab nor prophylactic intrathecal chemotherapy could effectively prevent CNS relapse for PB‐DLBCL patients. Primary breast diffuse large B ‐cell lymphoma (PB‐DLBCL) is a rare subtype of DLBCL with limited data on patterns of failure. This multicenter study aimed to define the optimum treatment strateg...
Source: Cancer Science - November 11, 2018 Category: Cancer & Oncology Authors: Shaoxuan Hu, Yuqin Song, Xiuhua Sun, Liping Su, Wei Zhang, Jing Jia, Ou Bai, Sheng Yang, Rong Liang, Xiaoling Li, Huilai Zhang, Yuhuan Gao, Weijing Zhang, Xiubin Xiao, Huizheng Bao, Ningju Wang, Hanyun Ren, Xinan Cen, Shun'e Yang, Yu Zh Tags: ORIGINAL ARTICLE Source Type: research

Single fraction carbon ion radiotherapy for colorectal cancer liver metastasis:A dose escalation study
This article is protected by copyright. All rights reserved. (Source: Cancer Science)
Source: Cancer Science - November 11, 2018 Category: Cancer & Oncology Authors: Hirokazu Makishima, Shigeo Yasuda, Yuka Isozaki, Goro Kasuya, Naomi Okada, Masaru Miyazaki, Osama Mohamad, Naruhiro Matsufuji, Shigeru Yamada, Hiroshi Tsuji, Tadashi Kamada, The Liver Cancer Working Group Tags: Original Article Source Type: research

Chemokine (C ‐X‐C motif) ligand 1 and CXCL2 produced by tumor promote the generation of monocytic myeloid‐derived suppressor cells
Our results elucidated that CXCL1 and CXCL2, which were originally characterized as chemokines of neutrophils, specifically promoted the expansion of mo ‐MDSC, a subtype of MDSC, in the presence of GM‐CSF. Moreover, we found that, in addition to the tumor cells, tumor‐infiltrated CD11b+ myeloid cells also expressed CXCL1 and CXCL2. Therefore, inhibition of CXCL1 and CXCL2 could decrease mo‐MDSC generation and improve host immunosurveillance. Accumulation of myeloid ‐derived suppressor cells (MDSC) in tumor‐bearing hosts is a hallmark of tumor‐associated inflammation, which is thought to be a barrier to immuno...
Source: Cancer Science - November 8, 2018 Category: Cancer & Oncology Authors: Huifang Shi, Xiaoqing Han, Yingying Sun, Chao Shang, Min Wei, Xueqing Ba, Xianlu Zeng Tags: ORIGINAL ARTICLE Source Type: research

Tumor ‐derived exosomal proteins as diagnostic biomarkers in non‐small cell lung cancer
This article is protected by copyright. All rights reserved. (Source: Cancer Science)
Source: Cancer Science - November 8, 2018 Category: Cancer & Oncology Authors: Limin Niu, Xingguo Song, Ning Wang, Linlin Xue, Xianrang Song, Li Xie Tags: Original Article Source Type: research

NEDD8 promotes the tumor progression and predicts the poor prognosis of patients with bladder cancer
In conclusion,NEDD8 possessed important roles in regulating the progression of BC cells and was associated with the poor prognosis of patients, which may become a potential therapeutic target of BC.This article is protected by copyright. All rights reserved. (Source: Cancer Science)
Source: Cancer Science - November 8, 2018 Category: Cancer & Oncology Authors: Da ‐Wei Tian, Zhou‐Liang Wu, Li‐Ming Jiang, Jie Gao, Chang‐Li Wu, Hai‐Long Hu Tags: Original Article Source Type: research

PODXL promotes gastric cancer progression through interacting with RUFY1 protein
This article is protected by copyright. All rights reserved. (Source: Cancer Science)
Source: Cancer Science - November 8, 2018 Category: Cancer & Oncology Authors: Qiaoming Zhi, Huo Chen, Fei Liu, Ye Han, Daiwei Wan, Zhihua Xu, Yuting Kuang, Jin Zhou Tags: Original Article Source Type: research

MORC2 promotes development of an aggressive colorectal cancer phenotype through inhibition of NDRG1
This article is protected by copyright. All rights reserved. (Source: Cancer Science)
Source: Cancer Science - November 8, 2018 Category: Cancer & Oncology Authors: Jiao Liu, Yangguang Shao, Yuxin He, Ke Ning, Xi Cui, Furong Liu, Zhenning Wang, Feng Li Tags: Original Article Source Type: research

Functional intronic variant of SLC5A10 affects DRG2 expression and survival outcomes of early ‐stage non‐small‐cell lung cancer
This study was approved by the Institutional Review Broad of Kyungpook National University of Hospital (Approval No. KNUMC 2014‐04‐210‐003). (Source: Cancer Science)
Source: Cancer Science - November 7, 2018 Category: Cancer & Oncology Authors: Mi Jeong Hong, Seung Soo Yoo, Jin Eun Choi, Hyo ‐Gyoung Kang, Sook Kyung Do, Jang Hyuck Lee, Won Kee Lee, Jaehee Lee, Shin Yup Lee, Seung Ick Cha, Chang Ho Kim, Eung Bae Lee, Sukki Cho, Sanghoon Jheon, Jae Yong Park Tags: ORIGINAL ARTICLE Source Type: research

FBXW7 modulates malignant potential and cisplatin ‐induced apoptosis in cholangiocarcinoma through NOTCH1 and MCL1
Cancer Science, EarlyView. (Source: Cancer Science)
Source: Cancer Science - November 5, 2018 Category: Cancer & Oncology Authors: Akiko Mori, Kunihiro Masuda, Hideo Ohtsuka, Masahiro Shijo, Kyohei Ariake, Koji Fukase, Naoaki Sakata, Masamichi Mizuma, Takanori Morikawa, Hiroki Hayashi, Kei Nakagawa, Fuyuhiko Motoi, Takeshi Naitoh, Fumiyoshi Fujishima, Michiaki Unno Source Type: research

Epidermal growth factor receptor promotes glioma progression by regulating xCT and GluN2B ‐containing N‐methyl‐d‐aspartate–sensitive glutamate receptor signaling
Cancer Science, EarlyView. (Source: Cancer Science)
Source: Cancer Science - November 5, 2018 Category: Cancer & Oncology Authors: Kentaro Suina, Kenji Tsuchihashi, Juntaro Yamasaki, Shohei Kamenori, Subaru Shintani, Yuki Hirata, Shogo Okazaki, Oltea Sampetrean, Eishi Baba, Koichi Akashi, Yoichiro Mitsuishi, Fumiyuki Takahashi, Kazuhisa Takahashi, Hideyuki Saya, Osamu N Source Type: research

A group of long noncoding RNAs identified by data mining can predict the prognosis of lung adenocarcinoma
Cancer Science, EarlyView. (Source: Cancer Science)
Source: Cancer Science - November 5, 2018 Category: Cancer & Oncology Authors: Meijian Liao, Qing Liu, Bing Li, Weijie Liao, Weidong Xie, Yaou Zhang Source Type: research