Coupling function of CDK2 and SEPT2 in the promotion of hepatocellular carcinoma
This article is protected by copyright. All rights reserved. (Source: Cancer Science)
Source: Cancer Science - November 16, 2018 Category: Cancer & Oncology Authors: Chenzhou Xu,
Wei Zhang,
Xuening Zhang,
Danhua Zhou,
Qu Lishuai,
Jinxia Liu,
Mingbing Xiao,
Runzhou Ni,
Feng Jiang,
Wenkai Ni,
Cuihua Lu Tags: Original Article Source Type: research
Antibiotics Suppress Colon Tumorigenesis Through Inhibition of Aberrant DNA Methylation in an AOM/DSS Colitis Model
This article is protected by copyright. All rights reserved. (Source: Cancer Science)
Source: Cancer Science - November 16, 2018 Category: Cancer & Oncology Authors: Naoko Hattori,
Tohru Niwa,
Tatsuya Ishida,
Kyosuke Kobayashi,
Toshio Imai,
Akiko Mori,
Kana Kimura,
Takeshi Mori,
Yukio Asami,
Toshikazu Ushijima Tags: Original Article Source Type: research
An amino acid metabolism ‐related gene expression‐based risk signature can better predict overall survival for glioma
This article is protected by copyright. All rights reserved. (Source: Cancer Science)
Source: Cancer Science - November 15, 2018 Category: Cancer & Oncology Authors: Yu ‐Qing Liu,
Rui‐Chao Chai,
Yong‐Zhi Wang,
Zheng Wang,
Xing Liu,
Fan Wu,
Tao Jiang Tags: Original Article Source Type: research
20(S) ‐ginsenoside‐Rg3 reverses temozolomide resistance and restrains epithelial‐mesenchymal transition progression in glioblastoma
This article is protected by copyright. All rights reserved. (Source: Cancer Science)
Source: Cancer Science - November 15, 2018 Category: Cancer & Oncology Authors: Zheng Chen,
Xiangyu Wei,
Lin Shen,
Hanshuo Zhu,
Xuesheng Zheng Tags: Original Article Source Type: research
Downregulation of lncRNA OIP5 ‐AS1 inhibits breast cancer progression by targeting SOX2 via miRNA‐129‐5p upregulation
This study investigated the role of the lncRNA OIP5‐AS1 in the progression of breast cancer. OIP5‐AS1 was significantly upregulated in breast cancer tissues and breast cancer cell lines, and OIP5‐AS1 downregulation inhibited the malignant be haviors of breast cancerin vitro andin vivo. For the depth exploration of mechanism of OIP5 ‐AS1 in breast cancer, we found that miR‐129‐5p which was found had bind sites in the sequence of OIP5‐AS1, expression in breast cancer tissues was negatively correlated with OIP5‐AS1 and luciferase assays indicated that OIP5‐AS1 acted as miR‐129‐5p sponge, resulting in upr...
Source: Cancer Science - November 15, 2018 Category: Cancer & Oncology Authors: Huijuan Zeng,
Jingjie Wang,
Tao Chen,
Kai Zhang,
Jing Chen,
Lulu Wang,
Hanjun Li,
Dilihumaer Tuluhong,
Jieshou Li,
Shaohua Wang Tags: Original Article Source Type: research
Functionally impaired follicular helper T cells induce regulatory B cells and CD14+ human leukocyte antigen ‐DR− cell differentiation in non‐small cell lung cancer
Non ‐small cell lung cancer patients have high levels of Tfh cells, especially Tfh2 and Tfh17 subtypes, but Tfh cells from NSCLC patients have impaired function of IL‐21 production and Tfh cells induced the differentiation of regulatory B cells and CD14+ HLA ‐DR− cells. Non ‐small cell lung cancer (NSCLC) represents one of the most common and aggressive cancers worldwide, as it typically displays irreversible progression and poor prognosis. Interaction between programmed death 1 (PD‐1) and its ligand, PD‐L1, plays important roles in tumor immunology. Follicular h elper T (Tfh) cells have characteristically hi...
Source: Cancer Science - November 14, 2018 Category: Cancer & Oncology Authors: Liannv Qiu,
Qinhua Yu,
Yonglie Zhou,
Sujie Zheng,
Jiaojiao Tao,
Qian Jiang,
Guorong Yuan Tags: Original Article Source Type: research
Phosphorylation of serine/arginine ‐rich splicing factor 1 at tyrosine 19 promotes cell proliferation in pediatric acute lymphoblastic leukemia
In conclusion, we identify for the first time that the phosphorylation state of SRSF1 is linked to different phases in pediat ric ALL. The Tyr‐19 phosphorylation of SRSF1 disrupts its subcellular localization and promotes proliferation in leukemia cells by driving cell‐cycle progression. Inhibitors targeting Tie2 kinase that could catalyze Tyr‐19 phosphorylation of SRSF1 offer a promising therapeutic target for treat ment of pediatric ALL. (Source: Cancer Science)
Source: Cancer Science - November 14, 2018 Category: Cancer & Oncology Authors: Liting Xu,
Han Zhang,
Mei Mei,
Chaohao Du,
Xiahe Huang,
Jing Li,
Yingchun Wang,
Shilai Bao,
Huyong Zheng Tags: ORIGINAL ARTICLE Source Type: research
Pattern and prognostic value of FLT3 ‐ITD mutations in Chinese de novo adult acute myeloid leukemia
A total of 227 FLT3 ‐ITD sequences were analyzed from 227 Chinese adult de novo acute myeloid leukemia (AML) patients. ITD could be classified into 3 types based on molecular profiles. ITD integration sites in the hinge region or beta1‐sheet region are an unfavorable prognostic factor in adult AML patients with FLT 3‐ITD mutations. FMS ‐like tyrosine kinase 3 (FLT3) is one of the most frequently mutated genes in hematological malignancies.FLT3 internal tandem duplication (FLT3‐ITD) mutations located in juxtamembrane domain (JMD) and tyrosine kinase domain 1 (TKD1) regions account for two‐thirds of allFLT3 mutat...
Source: Cancer Science - November 14, 2018 Category: Cancer & Oncology Authors: Song ‐Bai Liu,
Qiao‐Cheng Qiu,
Xie‐Bing Bao,
Xiao Ma,
Hong‐Zhi Li,
Yue‐Jun Liu,
Su‐Ning Chen,
Yao‐Hua Song,
De‐Pei Wu,
Sheng‐Li Xue Tags: ORIGINAL ARTICLE Source Type: research
Pyruvate secreted from patient ‐derived cancer‐associated fibroblasts supports survival of primary lymphoma cells
This article is protected by copyright. All rights reserved. (Source: Cancer Science)
Source: Cancer Science - November 13, 2018 Category: Cancer & Oncology Authors: Akihiko Sakamoto,
Shunsuke Kunou,
Kazuyuki Shimada,
Makoto Tsunoda,
Tomohiro Aoki,
Chisako Iriyama,
Akihiro Tomita,
Shigeo Nakamura,
Fumihiko Hayakawa,
Hitoshi Kiyoi Tags: Original Article Source Type: research
CCL2 Induces Resistance to the Antiproliferative Effect of Cabazitaxel in Prostate Cancer Cells
This article is protected by copyright. All rights reserved. (Source: Cancer Science)
Source: Cancer Science - November 13, 2018 Category: Cancer & Oncology Authors: Ariunbold Natsagdorj,
Kouji Izumi,
Kaoru Hiratsuka,
Kazuaki Machioka,
Hiroaki Iwamoto,
Renato Naito,
Tomoyuki Makino,
Suguru Kadomoto,
Kazuyoshi Shigehara,
Yoshifumi Kadono,
Wen ‐Jye Lin,
Aerken Maolake,
Atsushi Mizokami Tags: Original Article Source Type: research
PD ‐L1 expression enhancement by infiltrating macrophage‐derived TNF‐α leads to poor pancreatic cancer prognosis
This article is protected by copyright. All rights reserved. (Source: Cancer Science)
Source: Cancer Science - November 13, 2018 Category: Cancer & Oncology Authors: Masayo Tsukamoto,
Katsunori Imai,
Takatsugu Ishimoto,
Yoshihiro Komohara,
Yo ‐ichi Yamashita,
Shigeki Nakagawa,
Naoki Umezaki,
Takanobu Yamao,
Yuki Kitano,
Tatsunori Miyata,
Kota Arima,
Hirohisa Okabe,
Yoshifumi Baba,
Akira Chikamoto,
Taka Tags: Original Article Source Type: research
T cell receptor β‐chain repertoire analysis of tumor infiltrating lymphocytes in pancreatic cancer
This study aimed to test the relationship between the TCR β repertoire of the tumor and peripheral blood, and also to investigate the intra‐tumor spatial heterogeneity of the TCR β repertoire in pancreatic cancer. To the best of our knowledge, this is the first study to evaluate the clonal composition of TCR β repertoire in TILs across the spatial ext ent of pancreatic cancer.In this study, we studied five patients who were diagnosed with primary pancreatic cancer. Ultra ‐deep sequencing was used to assess the rearrangement of the TCR β‐chain (TCR β) gene. HE staining and immunohistochemistry of CD3, CD4, CD8 an...
Source: Cancer Science - November 13, 2018 Category: Cancer & Oncology Authors: Can Cui,
Xiuyun Tian,
Jianhui Wu,
Chaoting Zhang,
Qin Tan,
Xiaoya Guan,
Bin Dong,
Min Zhao,
Zheming Lu,
Chunyi Hao Tags: Original Article Source Type: research
Y ‐box binding protein‐1 promotes tumorigenesis and progression via the EGFR/AKT pathway in spinal chordoma
This article is protected by copyright. All rights reserved. (Source: Cancer Science)
Source: Cancer Science - November 13, 2018 Category: Cancer & Oncology Authors: Chen Liang,
Yunlong Ma,
Lei Yong,
Chenlong Yang,
Peng Wang,
Xiao Liu,
Bin Zhu,
Hua Zhou,
Xiaoguang Liu,
Zhongjun Liu Tags: Original Article Source Type: research
Exploration of resistance mechanisms for epidermal growth factor receptor ‐tyrosine kinase inhibitors based on plasma analysis by digital polymerase chain reaction and next‐generation sequencing
Quantitation of T790M in plasma is a clinically relevant approach to determine the T790M status of tumors. Liquid biopsy offers a potential alternative to tissue biopsy for detection of genetic alterations in cancer, and it has been introduced into clinical practice to detect the tyrosine kinase inhibitor (TKI) resistance ‐conferring T790M mutation of epidermal growth factor receptor (EGFR) in patients with non ‐small‐cell lung cancer (NSCLC). We prospectively collected tumor and plasma samples from 25 NSCLC patients who harbored activating mutations ofEGFR and experienced failure of treatment with afatinib. The samp...
Source: Cancer Science - November 13, 2018 Category: Cancer & Oncology Authors: Eiji Iwama,
Kazuko Sakai,
Koichi Azuma,
Daijiro Harada,
Kaname Nosaki,
Katsuyuki Hotta,
Makoto Nishio,
Takayasu Kurata,
Tatsuro Fukuhara,
Hiroaki Akamatsu,
Koichi Goto,
Takayuki Shimose,
Junji Kishimoto,
Yoichi Nakanishi,
Kazuto Nishio,
Isa Tags: ORIGINAL ARTICLE Source Type: research
Alternative RNA splicing of the GIT1 gene is associated with neuroendocrine prostate cancer
This article is protected by copyright. All rights reserved. (Source: Cancer Science)
Source: Cancer Science - November 12, 2018 Category: Cancer & Oncology Authors: Ahn R Lee,
Yu Gan,
Ning Xie,
Varune R Ramnarine,
Jessica M Lovnicki,
Xuesen Dong Tags: Original Article Source Type: research
