Correction: Efficacy of Cotargeting Angiopoietin-2 and the VEGF Pathway in the Adjuvant Postsurgical Setting for Early Breast, Colorectal, and Renal Cancers
(Source: Cancer Research)
Source: Cancer Research - April 2, 2017 Category: Cancer & Oncology Tags: Corrections Source Type: research
Correction: EpCAM-Regulated Transcription Exerts Influences on Nanomechanical Properties of Endometrial Cancer Cells That Promote Epithelial-to-Mesenchymal Transition
(Source: Cancer Research)
Source: Cancer Research - April 2, 2017 Category: Cancer & Oncology Tags: Corrections Source Type: research
EGFR-Dependent Regulated Intramembrane Proteolysis of EpCAM—Response
(Source: Cancer Research)
Source: Cancer Research - April 2, 2017 Category: Cancer & Oncology Authors: Ya-Ting Hsu, Pawel Osmulski, Yao Wang, Yi-Wen Huang, Lu Liu, Jianhua Ruan, Victor X. Jin, Nameer B. Kirma, Maria E. Gaczynska, Tim Hui-Ming Huang Tags: Letters to the Editor Source Type: research
EGFR-Dependent Regulated Intramembrane Proteolysis of EpCAM—Letter
(Source: Cancer Research)
Source: Cancer Research - April 2, 2017 Category: Cancer & Oncology Authors: Olivier Gires Tags: Letters to the Editor Source Type: research
Oncogenic Effects of High MAPK Activity in Colorectal Cancer Mark Progenitor Cells and Persist Irrespective of RAS Mutations
About 40% of colorectal cancers have mutations in KRAS accompanied by downstream activation of MAPK signaling, which promotes tumor invasion and progression. Here, we report that MAPK signaling shows strong intratumoral heterogeneity and unexpectedly remains regulated in colorectal cancer irrespective of KRAS mutation status. Using primary colorectal cancer tissues, xenograft models, and MAPK reporter constructs, we showed that tumor cells with high MAPK activity resided specifically at the leading tumor edge, ceased to proliferate, underwent epithelial–mesenchymal transition (EMT), and expressed markers related to colon...
Source: Cancer Research - April 2, 2017 Category: Cancer & Oncology Authors: Cristina Blaj, Eva Marina Schmidt, Sebastian Lamprecht, Heiko Hermeking, Andreas Jung, Thomas Kirchner, David Horst Tags: Tumor and Stem Cell Biology Source Type: research
