British Journal of Clinical Pharmacology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Self ‐poisoning with 60 tablets of Apixaban, a pharmacokinetics case report
This report suggests that the use of activated charcoal should be effective up to 17 h after a massive intake. (Source: British Journal of Clinical Pharmacology)
Source: British Journal of Clinical Pharmacology - November 12, 2018 Category: Drugs & Pharmacology Authors: B énédicte Franck, Sylvain Dulaurent, Souleiman El Balkhi, Caroline Monchaud, Nicolas Picard, Sylvain Couderc, Pierre Marquet, Franck Saint‐Marcoux, Jean‐Baptiste Woillard Tags: CASE REPORT Source Type: research

Once ‐daily darunavir/ritonavir 400/100 mg in triple therapy: efficacy and penetration in seminal compartment in ANRS‐165 DARULIGHT study
British Journal of Clinical Pharmacology, EarlyView. (Source: British Journal of Clinical Pharmacology)
Source: British Journal of Clinical Pharmacology - November 12, 2018 Category: Drugs & Pharmacology Authors: Minh P. L ê, Marie‐Laure Chaix, François Raffi, Sylvie Chevret, Sébastien Gallien, Christine Katlama, Pierre Delobel, Yazdan Yazdanpanah, Juliette Saillard, Jean‐Michel Molina, Gilles Peytavin, the ANRS‐165 DARULIGHT study group Tags: LETTER TO THE EDITOR Source Type: research

Restricting maintenance allopurinol dose according to kidney function in patients with gout is inappropriate!
British Journal of Clinical Pharmacology, EarlyView. (Source: British Journal of Clinical Pharmacology)
Source: British Journal of Clinical Pharmacology - November 12, 2018 Category: Drugs & Pharmacology Authors: Lisa K. Stamp, Daniel F.B. Wright, Nicola Dalbeth Tags: LETTER TO THE EDITOR Source Type: research

Teicoplanin hypersensitivity during anaesthesia and surgery
British Journal of Clinical Pharmacology, EarlyView. (Source: British Journal of Clinical Pharmacology)
Source: British Journal of Clinical Pharmacology - November 12, 2018 Category: Drugs & Pharmacology Authors: Paul James Antony Sice, Sarah Ford, Andrew Francis Whyte, James Robertson Greig Tags: LETTER TO THE EDITOR Source Type: research

Reply to ‘Overuse or underuse of methylphenidate in adults in France: commentary on Pauly et al. 2018’ by Weibel et al.
British Journal of Clinical Pharmacology, EarlyView. (Source: British Journal of Clinical Pharmacology)
Source: British Journal of Clinical Pharmacology - November 12, 2018 Category: Drugs & Pharmacology Authors: Vanessa Pauly, Elisabeth Frauger, Marion Lepelley, Michel Mallaret, Quentin Boucherie, Joelle Micallef Tags: LETTER TO THE EDITOR Source Type: research

Prolonged central apnoea after intravenous morphine administration in a 12 ‐year‐old male with a UGT1A1 loss‐of‐function polymorphism
Adverse eventRepeated and prolonged episodes of central apnoea and hypoxia after receiving intravenous morphine for analgesia and ketamine for sedation.Drug implicatedIntravenous morphine sulfate.The patientPreviously healthy 12 ‐year‐old male with no history of sleep apnoea who presented with distal tibia and fibula fracture.Evidence that links drug to eventPharmacogenomic testing revealed that the patient was homozygous for the T allele at the rs887829 SNP inUGT1A1, an enzyme involved in the metabolism of morphine. This polymorphism is a loss ‐of‐function variant, leading to impaired metabolism of morphine.Mechan...
Source: British Journal of Clinical Pharmacology - November 12, 2018 Category: Drugs & Pharmacology Authors: Michael S. Toce, Hyun Kim, Sarita Chung, Baruch S. Krauss Tags: CASE REPORT Source Type: research

Pharmacokinetic ‐pharmacodynamic modelling of platelet response to ticagrelor in stable coronary artery disease and prior myocardial infarction patients
ConclusionsIn patients with stable CAD or a history of MI, near maximal platelet inhibition is achieved with both ticagrelor 60 and 90 mg twice daily. At modeled doses below 60mg, the response is overall reduced, more variable between patients, and patients will display greater peak ‐to‐trough variability. (Source: British Journal of Clinical Pharmacology)
Source: British Journal of Clinical Pharmacology - November 10, 2018 Category: Drugs & Pharmacology Authors: Magnus Åstrand, Carl Amilon, Daniel Röshammar, Anders Himmelmann, Dominick J. Angiolillo, Robert F. Storey, Paul A. Gurbel, Marc P. Bonaca, Bengt Hamrén Tags: ORIGINAL ARTICLE Source Type: research

The Impact of Tacrolimus Exposure on Extrarenal Adverse Effects in Adult Renal Transplant Recipients
ConclusionsSeveral AEs (i.e., diarrhea, dyspepsia, insomnia, and neurologic AE ratio) were associated with tacrolimus dose normalized AUCss,0 ‐12hr, and clearance. Skin changes and acne were associated with dose ‐normalized CMAX concentrations. To facilitate clinical implementation, a LSS was developed to predict AUCss,0 ‐12hr values using sparse patient data to efficiently assess projected immunosuppressive exposure and potentially minimize AE manifestations. (Source: British Journal of Clinical Pharmacology)
Source: British Journal of Clinical Pharmacology - November 10, 2018 Category: Drugs & Pharmacology Authors: Olivia Campagne, Donald E. Mager, Daniel Brazeau, Rocco C. Venuto, Kathleen M. Tornatore Tags: ORIGINAL ARTICLE Source Type: research

Successful and safe long ‐term treatment of cerebral aspergillosis with high‐dose voriconazole guided by therapeutic drug monitoring
We report the case of a patient who had cerebral aspergillosis after otorhinolaryngologic surgery and who was successfully and safely treated with high ‐dose voriconazole (200 mg q6h) for more than 1 year thanks to a TDM‐guided approach coupled with pharmacological review and with genotyping of CYP2C19 polymorphisms. The findings support the idea that personalized medicine based on TDM coupled with the need of avoiding drug–drug interaction s may be helpful for maximizing the net benefit (probability of efficacyvs. probability of adverse events) of voriconazole in the management of long ‐term treatment of cerebra...
Source: British Journal of Clinical Pharmacology - November 9, 2018 Category: Drugs & Pharmacology Authors: Pier Giorgio Cojutti, Maria Merelli, Lorenzo Allegri, Giuseppe Damante, Matteo Bassetti, Federico Pea Tags: CASE REPORT Source Type: research